FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154262807> ?p ?o ?g. }

• W2154262807 endingPage "5695" @default.
• W2154262807 startingPage "5685" @default.
• W2154262807 abstract "alpha-Dystroglycan (DG) is an important cellular receptor for extracellular matrix (ECM) proteins and also serves as the receptor for Old World arenaviruses Lassa fever virus (LFV) and lymphocytic choriomeningitis virus (LCMV) and clade C New World arenaviruses. In the host cell, alpha-DG is subject to a remarkably complex pattern of O glycosylation that is crucial for its interactions with ECM proteins. Two of these unusual sugar modifications, protein O mannosylation and glycan modifications involving the putative glycosyltransferase LARGE, have recently been implicated in arenavirus binding. Considering the complexity of alpha-DG O glycosylation, our present study was aimed at the identification of the specific O-linked glycans on alpha-DG that are recognized by arenaviruses. As previously shown for LCMV, we found that protein O mannosylation of alpha-DG is crucial for the binding of arenaviruses of distinct phylogenetic origins, including LFV, Mobala virus, and clade C New World arenaviruses. In contrast to the highly conserved requirement for O mannosylation, more generic O glycans present on alpha-DG are dispensable for arenavirus binding. Despite the critical role of O-mannosyl glycans for arenavirus binding under normal conditions, the overexpression of LARGE in cells deficient in O mannosylation resulted in highly glycosylated alpha-DG that was functional as a receptor for arenaviruses. Thus, modifications by LARGE but not O-mannosyl glycans themselves are most likely the crucial structures recognized by arenaviruses. Together, the data demonstrate that arenaviruses recognize the same highly conserved O-glycan structures on alpha-DG involved in ECM protein binding, indicating a strikingly similar mechanism of receptor recognition by pathogen- and host-derived ligands." @default.
• W2154262807 created "2016-06-24" @default.
• W2154262807 creator A5034664089 @default.
• W2154262807 creator A5036383920 @default.
• W2154262807 creator A5052247595 @default.
• W2154262807 creator A5085822063 @default.
• W2154262807 date "2007-06-01" @default.
• W2154262807 modified "2023-09-26" @default.
• W2154262807 title "Old World and Clade C New World Arenaviruses Mimic the Molecular Mechanism of Receptor Recognition Used by α-Dystroglycan's Host-Derived Ligands" @default.
• W2154262807 cites W1549823484 @default.
• W2154262807 cites W1580934676 @default.
• W2154262807 cites W1584590209 @default.
• W2154262807 cites W1633002272 @default.
• W2154262807 cites W164466502 @default.
• W2154262807 cites W169389978 @default.
• W2154262807 cites W1706783875 @default.
• W2154262807 cites W176065139 @default.
• W2154262807 cites W1791196248 @default.
• W2154262807 cites W1963757547 @default.
• W2154262807 cites W1969699638 @default.
• W2154262807 cites W1972123019 @default.
• W2154262807 cites W1972695095 @default.
• W2154262807 cites W1975070570 @default.
• W2154262807 cites W1981646935 @default.
• W2154262807 cites W1989887649 @default.
• W2154262807 cites W1990735189 @default.
• W2154262807 cites W1993505002 @default.
• W2154262807 cites W1999765737 @default.
• W2154262807 cites W2002246451 @default.
• W2154262807 cites W2004228578 @default.
• W2154262807 cites W2006932846 @default.
• W2154262807 cites W2008115339 @default.
• W2154262807 cites W2012354708 @default.
• W2154262807 cites W2014303931 @default.
• W2154262807 cites W2023624588 @default.
• W2154262807 cites W2024191848 @default.
• W2154262807 cites W2025642516 @default.
• W2154262807 cites W2031907757 @default.
• W2154262807 cites W2036145275 @default.
• W2154262807 cites W2038642657 @default.
• W2154262807 cites W2046338312 @default.
• W2154262807 cites W2051062800 @default.
• W2154262807 cites W2054564977 @default.
• W2154262807 cites W2061840081 @default.
• W2154262807 cites W2062628051 @default.
• W2154262807 cites W2077753375 @default.
• W2154262807 cites W2084198615 @default.
• W2154262807 cites W2085818819 @default.
• W2154262807 cites W2090004322 @default.
• W2154262807 cites W2091344926 @default.
• W2154262807 cites W2091677322 @default.
• W2154262807 cites W2104306412 @default.
• W2154262807 cites W2107712284 @default.
• W2154262807 cites W2124390040 @default.
• W2154262807 cites W2135383773 @default.
• W2154262807 cites W2137200950 @default.
• W2154262807 cites W2149811187 @default.
• W2154262807 cites W2150114245 @default.
• W2154262807 cites W2169135788 @default.
• W2154262807 cites W2171721922 @default.
• W2154262807 cites W4240482344 @default.
• W2154262807 doi "https://doi.org/10.1128/jvi.02574-06" @default.
• W2154262807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1900301" @default.
• W2154262807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17360738" @default.
• W2154262807 hasPublicationYear "2007" @default.
• W2154262807 type Work @default.
• W2154262807 sameAs 2154262807 @default.
• W2154262807 citedByCount "62" @default.
• W2154262807 countsByYear W21542628072012 @default.
• W2154262807 countsByYear W21542628072013 @default.
• W2154262807 countsByYear W21542628072014 @default.
• W2154262807 countsByYear W21542628072015 @default.
• W2154262807 countsByYear W21542628072016 @default.
• W2154262807 countsByYear W21542628072017 @default.
• W2154262807 countsByYear W21542628072018 @default.
• W2154262807 countsByYear W21542628072019 @default.
• W2154262807 countsByYear W21542628072020 @default.
• W2154262807 countsByYear W21542628072021 @default.
• W2154262807 countsByYear W21542628072022 @default.
• W2154262807 countsByYear W21542628072023 @default.
• W2154262807 crossrefType "journal-article" @default.
• W2154262807 hasAuthorship W2154262807A5034664089 @default.
• W2154262807 hasAuthorship W2154262807A5036383920 @default.
• W2154262807 hasAuthorship W2154262807A5052247595 @default.
• W2154262807 hasAuthorship W2154262807A5085822063 @default.
• W2154262807 hasBestOaLocation W21542628071 @default.
• W2154262807 hasConcept C108625454 @default.
• W2154262807 hasConcept C154317977 @default.
• W2154262807 hasConcept C159047783 @default.
• W2154262807 hasConcept C202751555 @default.
• W2154262807 hasConcept C206212055 @default.
• W2154262807 hasConcept C2522874641 @default.
• W2154262807 hasConcept C2777313579 @default.
• W2154262807 hasConcept C2777427142 @default.
• W2154262807 hasConcept C2779574689 @default.
• W2154262807 hasConcept C2780190958 @default.
• W2154262807 hasConcept C54355233 @default.
• W2154262807 hasConcept C86803240 @default.

• next