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• W2154265087 startingPage "645" @default.
• W2154265087 abstract "Therapeutic cancer vaccination is an attractive strategy because it induces T cells of the immune system to recognize and kill tumour cells in cancer patients. However, it remains difficult to generate large numbers of T cells that can recognize the antigens on cancer cells using conventional vaccine carrier systems. Here we show that α-Al(2)O(3) nanoparticles can act as an antigen carrier to reduce the amount of antigen required to activate T cells in vitro and in vivo. We found that α-Al(2)O(3) nanoparticles delivered antigens to autophagosomes in dendritic cells, which then presented the antigens to T cells through autophagy. Immunization of mice with α-Al(2)O(3) nanoparticles that are conjugated to either a model tumour antigen or autophagosomes derived from tumour cells resulted in tumour regression. These results suggest that α-Al(2)O(3) nanoparticles may be a promising adjuvant in the development of therapeutic cancer vaccines." @default.
• W2154265087 created "2016-06-24" @default.
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• W2154265087 date "2011-09-18" @default.
• W2154265087 modified "2023-09-29" @default.
• W2154265087 title "Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response" @default.
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• W2154265087 doi "https://doi.org/10.1038/nnano.2011.153" @default.
• W2154265087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3483867" @default.
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• W2154265087 hasPublicationYear "2011" @default.
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