FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154270070> ?p ?o ?g. }

• W2154270070 endingPage "4270" @default.
• W2154270070 startingPage "4263" @default.
• W2154270070 abstract "Porphyromonas (Bacteroides) gingivalis W12 binds and degrades human plasma fibronectin. In the presence of the protease inhibitor N-alpha-p-tosyl-L-lysyl chloromethyl ketone, P. gingivalis cells accumulated substantial amounts of 125I-fibronectin as a function of incubation time. Fibronectin binding was specific, reversible, and saturable. The Kd for the reaction was estimated to be on the order of 100 nM, and there was an average of 3.5 x 10(3) fibronectin binding sites per cell. Unlabeled fibronectin inhibited the binding of 125I-fibronectin to bacteria; however, fibrinogen was an even more efficient inhibitor of 125I-fibronectin binding. Unrelated proteins were without effect on fibronectin binding. A fibronectin-binding component (Mr, 150,000) was identified in sodium dodecyl sulfate-solubilized P. gingivalis. Fibronectin was degraded into discrete peptides by P. gingivalis W12. The degradation of fibronectin was inhibited by N-alpha-p-tosyl-L-lysyl chloromethyl ketone. Two P. gingivalis components (Mrs, 120,000 and 150,000) degraded fibronectin in substrate-containing gels following sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In a previous study (M. S. Lantz, R. D. Allen, T. A. Vail, L. M. Switalski, and M. Hook, J. Bacteriol. 173:495-504, 1991), we found that the same strain of P. gingivalis bound and subsequently degraded human fibrinogen via apparently distinct cell surface components of molecular sizes similar to those of components now implicated in the binding and degradation of fibronectin. These results raise the possibility that the two ligands are recognized and modified by the same components on P. gingivalis W12. In support of this hypothesis, unlabeled fibrinogen effectively inhibited the binding of 125I-fibronectin to bacteria and blocked 125I-fibronectin binding to a P. gingivalis ligand-binding component (Mr, 150,000 immobilized on a nitrocellulose membrane." @default.
• W2154270070 created "2016-06-24" @default.
• W2154270070 creator A5015798121 @default.
• W2154270070 creator A5037371114 @default.
• W2154270070 creator A5038729455 @default.
• W2154270070 creator A5062527254 @default.
• W2154270070 creator A5070151600 @default.
• W2154270070 creator A5090347366 @default.
• W2154270070 date "1991-07-01" @default.
• W2154270070 modified "2023-10-18" @default.
• W2154270070 title "Identification of Porphyromonas gingivalis components that mediate its interactions with fibronectin" @default.
• W2154270070 cites W108750973 @default.
• W2154270070 cites W1497884043 @default.
• W2154270070 cites W1530430739 @default.
• W2154270070 cites W1544973994 @default.
• W2154270070 cites W1605349637 @default.
• W2154270070 cites W1838864167 @default.
• W2154270070 cites W1886537447 @default.
• W2154270070 cites W1899714055 @default.
• W2154270070 cites W1910921588 @default.
• W2154270070 cites W1918862162 @default.
• W2154270070 cites W1927383242 @default.
• W2154270070 cites W193503258 @default.
• W2154270070 cites W1980042893 @default.
• W2154270070 cites W1983649348 @default.
• W2154270070 cites W1999876464 @default.
• W2154270070 cites W2003703104 @default.
• W2154270070 cites W2005165360 @default.
• W2154270070 cites W2018289835 @default.
• W2154270070 cites W2027393724 @default.
• W2154270070 cites W2027657428 @default.
• W2154270070 cites W2041906969 @default.
• W2154270070 cites W2052934871 @default.
• W2154270070 cites W2058126809 @default.
• W2154270070 cites W2061469613 @default.
• W2154270070 cites W2068022684 @default.
• W2154270070 cites W2077184675 @default.
• W2154270070 cites W2079831464 @default.
• W2154270070 cites W2101108802 @default.
• W2154270070 cites W2104284678 @default.
• W2154270070 cites W2122438899 @default.
• W2154270070 cites W2134415679 @default.
• W2154270070 cites W2134465835 @default.
• W2154270070 cites W2147162855 @default.
• W2154270070 cites W2150260980 @default.
• W2154270070 cites W2156383963 @default.
• W2154270070 cites W2172080926 @default.
• W2154270070 cites W2217683356 @default.
• W2154270070 cites W2415657283 @default.
• W2154270070 doi "https://doi.org/10.1128/jb.173.14.4263-4270.1991" @default.
• W2154270070 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/208085" @default.
• W2154270070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1829726" @default.
• W2154270070 hasPublicationYear "1991" @default.
• W2154270070 type Work @default.
• W2154270070 sameAs 2154270070 @default.
• W2154270070 citedByCount "69" @default.
• W2154270070 countsByYear W21542700702012 @default.
• W2154270070 countsByYear W21542700702013 @default.
• W2154270070 countsByYear W21542700702015 @default.
• W2154270070 countsByYear W21542700702017 @default.
• W2154270070 countsByYear W21542700702018 @default.
• W2154270070 countsByYear W21542700702021 @default.
• W2154270070 crossrefType "journal-article" @default.
• W2154270070 hasAuthorship W2154270070A5015798121 @default.
• W2154270070 hasAuthorship W2154270070A5037371114 @default.
• W2154270070 hasAuthorship W2154270070A5038729455 @default.
• W2154270070 hasAuthorship W2154270070A5062527254 @default.
• W2154270070 hasAuthorship W2154270070A5070151600 @default.
• W2154270070 hasAuthorship W2154270070A5090347366 @default.
• W2154270070 hasBestOaLocation W21542700702 @default.
• W2154270070 hasConcept C116084860 @default.
• W2154270070 hasConcept C1491633281 @default.
• W2154270070 hasConcept C153911025 @default.
• W2154270070 hasConcept C185592680 @default.
• W2154270070 hasConcept C2776357993 @default.
• W2154270070 hasConcept C2778913249 @default.
• W2154270070 hasConcept C2780183776 @default.
• W2154270070 hasConcept C523546767 @default.
• W2154270070 hasConcept C54355233 @default.
• W2154270070 hasConcept C55493867 @default.
• W2154270070 hasConcept C86492073 @default.
• W2154270070 hasConcept C86803240 @default.
• W2154270070 hasConcept C89423630 @default.
• W2154270070 hasConceptScore W2154270070C116084860 @default.
• W2154270070 hasConceptScore W2154270070C1491633281 @default.
• W2154270070 hasConceptScore W2154270070C153911025 @default.
• W2154270070 hasConceptScore W2154270070C185592680 @default.
• W2154270070 hasConceptScore W2154270070C2776357993 @default.
• W2154270070 hasConceptScore W2154270070C2778913249 @default.
• W2154270070 hasConceptScore W2154270070C2780183776 @default.
• W2154270070 hasConceptScore W2154270070C523546767 @default.
• W2154270070 hasConceptScore W2154270070C54355233 @default.
• W2154270070 hasConceptScore W2154270070C55493867 @default.
• W2154270070 hasConceptScore W2154270070C86492073 @default.
• W2154270070 hasConceptScore W2154270070C86803240 @default.
• W2154270070 hasConceptScore W2154270070C89423630 @default.
• W2154270070 hasIssue "14" @default.
• W2154270070 hasLocation W21542700701 @default.

• next