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• W2154271806 abstract "The blood-brain barrier (BBB) is damaged in tauopathies, including progressive supranuclear palsy (PSP) and Alzheimer’s disease (AD), which is thought to contribute to pathogenesis later in the disease course. In AD, BBB dysfunction has been associated with amyloid beta (Aß) pathology, but the role of tau in this process is not well characterized. Since increased BBB permeability is found in tauopathies without Aß pathology, like PSP, we suspected that tau accumulation alone could not only be sufficient, but even more important than Aß for BBB damage. Longitudinal evaluation of brain tissue from the tetracycline-regulatable rTg4510 tau transgenic mouse model showed progressive IgG, T cell and red blood cell infiltration. The Evans blue (EB) dye that is excluded from the brain when the BBB is intact also permeated the brains of rTg4510 mice following peripheral administration, indicative of a bonafide BBB defect, but this was only evident later in life. Thus, despite the marked brain atrophy and inflammation that occurs earlier in this model, BBB integrity is maintained. Interestingly, BBB dysfunction emerged at the same time that perivascular tau emerged around major hippocampal blood vessels. However, when tau expression was suppressed using doxycycline, BBB integrity was preserved, suggesting that the BBB can be stabilized in a tauopathic brain by reducing tau levels. For the first time, these data demonstrate that tau alone can initiate breakdown of the BBB, but the BBB is remarkably resilient, maintaining its integrity in the face of marked brain atrophy, neuroinflammation and toxic tau accumulation. Moreover, the BBB can recover integrity when tau levels are reduced. Thus, late stage interventions targeting tau may slow the vascular contributions to cognitive impairment and dementia that occur in tauopathies." @default.
• W2154271806 created "2016-06-24" @default.
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• W2154271806 creator A5086201900 @default.
• W2154271806 date "2015-01-31" @default.
• W2154271806 modified "2023-10-06" @default.
• W2154271806 title "Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy" @default.
• W2154271806 cites W1505146948 @default.
• W2154271806 cites W1516352634 @default.
• W2154271806 cites W1516817140 @default.
• W2154271806 cites W1536027939 @default.
• W2154271806 cites W1540257283 @default.
• W2154271806 cites W1584238807 @default.
• W2154271806 cites W1589304766 @default.
• W2154271806 cites W1620966995 @default.
• W2154271806 cites W1957400240 @default.
• W2154271806 cites W1963507435 @default.
• W2154271806 cites W1965709917 @default.
• W2154271806 cites W1967640115 @default.
• W2154271806 cites W1971775352 @default.
• W2154271806 cites W1972838584 @default.
• W2154271806 cites W1973278285 @default.
• W2154271806 cites W1976856337 @default.
• W2154271806 cites W1977074678 @default.
• W2154271806 cites W1986832216 @default.
• W2154271806 cites W1987727899 @default.
• W2154271806 cites W1991609190 @default.
• W2154271806 cites W1992758695 @default.
• W2154271806 cites W2003808683 @default.
• W2154271806 cites W2004346550 @default.
• W2154271806 cites W2004931286 @default.
• W2154271806 cites W2012458146 @default.
• W2154271806 cites W2013370441 @default.
• W2154271806 cites W2014875179 @default.
• W2154271806 cites W2015541518 @default.
• W2154271806 cites W2018505720 @default.
• W2154271806 cites W2022779476 @default.
• W2154271806 cites W2023312657 @default.
• W2154271806 cites W2024606460 @default.
• W2154271806 cites W2024816116 @default.
• W2154271806 cites W2027582763 @default.
• W2154271806 cites W2032069891 @default.
• W2154271806 cites W2032318569 @default.
• W2154271806 cites W2033349504 @default.
• W2154271806 cites W2033672635 @default.
• W2154271806 cites W2039405182 @default.
• W2154271806 cites W2047853787 @default.
• W2154271806 cites W2050206306 @default.
• W2154271806 cites W2052944919 @default.
• W2154271806 cites W2053858663 @default.
• W2154271806 cites W2054446458 @default.
• W2154271806 cites W2056613924 @default.
• W2154271806 cites W2063720739 @default.
• W2154271806 cites W2067295442 @default.
• W2154271806 cites W2069335131 @default.
• W2154271806 cites W2070251027 @default.
• W2154271806 cites W2071384955 @default.
• W2154271806 cites W2071698914 @default.
• W2154271806 cites W2074466423 @default.
• W2154271806 cites W2075964404 @default.
• W2154271806 cites W2080063195 @default.
• W2154271806 cites W2082392117 @default.
• W2154271806 cites W2082429191 @default.
• W2154271806 cites W2086623771 @default.
• W2154271806 cites W2089076186 @default.
• W2154271806 cites W2089135389 @default.
• W2154271806 cites W2093852116 @default.
• W2154271806 cites W2094944416 @default.
• W2154271806 cites W2099340107 @default.
• W2154271806 cites W2105036773 @default.
• W2154271806 cites W2107804537 @default.
• W2154271806 cites W2109646121 @default.
• W2154271806 cites W2112523443 @default.
• W2154271806 cites W2113126253 @default.
• W2154271806 cites W2128044935 @default.
• W2154271806 cites W2128109029 @default.
• W2154271806 cites W2128541869 @default.
• W2154271806 cites W2132438939 @default.
• W2154271806 cites W2135309154 @default.
• W2154271806 cites W2136922708 @default.
• W2154271806 cites W2142812465 @default.
• W2154271806 cites W2147959494 @default.
• W2154271806 cites W2148724745 @default.
• W2154271806 cites W2150449734 @default.
• W2154271806 cites W2152889673 @default.
• W2154271806 cites W2155365578 @default.
• W2154271806 cites W2158762199 @default.
• W2154271806 cites W2162531490 @default.
• W2154271806 cites W2167514717 @default.
• W2154271806 cites W2168056522 @default.
• W2154271806 cites W2221521015 @default.

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