FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154272635> ?p ?o ?g. }

• W2154272635 endingPage "4140" @default.
• W2154272635 startingPage "4133" @default.
• W2154272635 abstract "Abstract It is widely accepted that redox status, along with the partial pressure of oxygen (pO2), determines the efficacy of some therapeutic methods applied to treat tumors, including radiation. Redox status, evaluated by the reduction of a nitroxyl probe, was reportedly heterogeneous in a mouse tumor model. However, neither variation of heterogeneity of the redox status among mice nor the relation of the redox status to pO2 in tumors has been characterized sufficiently. In this study, the regional reduction status in a mouse radiation-induced fibrosarcoma tumor model was evaluated using sequential three-dimensional electron paramagnetic resonance (EPR) imaging after i.v. injection of a tissue-permeable nitroxyl probe, HM-PROXYL. The regional decay of HM-PROXYL signal obeyed first-order kinetics, and the amplitude of the reduction rate and extent of its heterogeneity in a tumor varied among six mice. The tissue pO2 was measured using EPR oximetry with lithium phthalocyanine (LiPc) microcrystals implanted within the tumor. The location of LiPc was determined with EPR imaging. A sequential image was obtained following the injection of HM-PROXYL, even after LiPc implantation, by choosing an HM-PROXYL signal peak which does not overlap with the signal of LiPc. The relationship between pO2 and the reduction rate at the region of pO2 measurement was found to be low (r = 0.357) in 13 tumor-bearing mice, indicating that the extent of oxygenation does not necessarily affect the redox status under air-breathing conditions. The results strongly indicate the necessity of measurements of both redox status and oxygenation in every tumor to characterize tumor physiology. Cancer Res; 70(10); 4133–40. ©2010 AACR." @default.
• W2154272635 created "2016-06-24" @default.
• W2154272635 creator A5000616950 @default.
• W2154272635 creator A5015015556 @default.
• W2154272635 creator A5019458192 @default.
• W2154272635 creator A5042343539 @default.
• W2154272635 creator A5044895844 @default.
• W2154272635 creator A5060329700 @default.
• W2154272635 creator A5079709806 @default.
• W2154272635 creator A5081250782 @default.
• W2154272635 creator A5081796926 @default.
• W2154272635 creator A5090469145 @default.
• W2154272635 date "2010-05-12" @default.
• W2154272635 modified "2023-10-16" @default.
• W2154272635 title "Heterogeneity of Regional Redox Status and Relation of the Redox Status to Oxygenation in a Tumor Model, Evaluated Using Electron Paramagnetic Resonance Imaging" @default.
• W2154272635 cites W1573834280 @default.
• W2154272635 cites W1608388738 @default.
• W2154272635 cites W1975614616 @default.
• W2154272635 cites W1987056520 @default.
• W2154272635 cites W1990353146 @default.
• W2154272635 cites W2001982092 @default.
• W2154272635 cites W2002497476 @default.
• W2154272635 cites W2005299119 @default.
• W2154272635 cites W2006581202 @default.
• W2154272635 cites W2007780823 @default.
• W2154272635 cites W2011375009 @default.
• W2154272635 cites W2013159295 @default.
• W2154272635 cites W2017530038 @default.
• W2154272635 cites W2018825597 @default.
• W2154272635 cites W2021512267 @default.
• W2154272635 cites W2025050268 @default.
• W2154272635 cites W2032514140 @default.
• W2154272635 cites W2035894048 @default.
• W2154272635 cites W2039870268 @default.
• W2154272635 cites W2042204431 @default.
• W2154272635 cites W2044507381 @default.
• W2154272635 cites W2050782978 @default.
• W2154272635 cites W2064296350 @default.
• W2154272635 cites W2065590448 @default.
• W2154272635 cites W2068258707 @default.
• W2154272635 cites W2071294948 @default.
• W2154272635 cites W2073042132 @default.
• W2154272635 cites W2079629366 @default.
• W2154272635 cites W2081176061 @default.
• W2154272635 cites W2108075715 @default.
• W2154272635 cites W2112741711 @default.
• W2154272635 cites W2116431705 @default.
• W2154272635 cites W2122722383 @default.
• W2154272635 cites W2162214261 @default.
• W2154272635 cites W2328719907 @default.
• W2154272635 doi "https://doi.org/10.1158/0008-5472.can-09-4369" @default.
• W2154272635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7366877" @default.
• W2154272635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20442282" @default.
• W2154272635 hasPublicationYear "2010" @default.
• W2154272635 type Work @default.
• W2154272635 sameAs 2154272635 @default.
• W2154272635 citedByCount "27" @default.
• W2154272635 countsByYear W21542726352012 @default.
• W2154272635 countsByYear W21542726352013 @default.
• W2154272635 countsByYear W21542726352014 @default.
• W2154272635 countsByYear W21542726352016 @default.
• W2154272635 countsByYear W21542726352017 @default.
• W2154272635 countsByYear W21542726352018 @default.
• W2154272635 countsByYear W21542726352019 @default.
• W2154272635 countsByYear W21542726352020 @default.
• W2154272635 countsByYear W21542726352021 @default.
• W2154272635 countsByYear W21542726352022 @default.
• W2154272635 crossrefType "journal-article" @default.
• W2154272635 hasAuthorship W2154272635A5000616950 @default.
• W2154272635 hasAuthorship W2154272635A5015015556 @default.
• W2154272635 hasAuthorship W2154272635A5019458192 @default.
• W2154272635 hasAuthorship W2154272635A5042343539 @default.
• W2154272635 hasAuthorship W2154272635A5044895844 @default.
• W2154272635 hasAuthorship W2154272635A5060329700 @default.
• W2154272635 hasAuthorship W2154272635A5079709806 @default.
• W2154272635 hasAuthorship W2154272635A5081250782 @default.
• W2154272635 hasAuthorship W2154272635A5081796926 @default.
• W2154272635 hasAuthorship W2154272635A5090469145 @default.
• W2154272635 hasBestOaLocation W21542726351 @default.
• W2154272635 hasConcept C121332964 @default.
• W2154272635 hasConcept C12554922 @default.
• W2154272635 hasConcept C126322002 @default.
• W2154272635 hasConcept C126838900 @default.
• W2154272635 hasConcept C142724271 @default.
• W2154272635 hasConcept C143409427 @default.
• W2154272635 hasConcept C148898269 @default.
• W2154272635 hasConcept C178790620 @default.
• W2154272635 hasConcept C179104552 @default.
• W2154272635 hasConcept C185592680 @default.
• W2154272635 hasConcept C187961010 @default.
• W2154272635 hasConcept C2776142628 @default.
• W2154272635 hasConcept C2776495794 @default.
• W2154272635 hasConcept C2779394729 @default.
• W2154272635 hasConcept C46141821 @default.
• W2154272635 hasConcept C540031477 @default.
• W2154272635 hasConcept C55904794 @default.
• W2154272635 hasConcept C62520636 @default.
• W2154272635 hasConcept C68463220 @default.

• next