FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154276864> ?p ?o ?g. }

• W2154276864 endingPage "e1002210" @default.
• W2154276864 startingPage "e1002210" @default.
• W2154276864 abstract "T-box proteins are conserved transcription factors that play crucial roles in development of all metazoans; and, in humans, mutations affecting T-box genes are associated with a variety of congenital diseases and cancers. Despite the importance of this transcription factor family, very little is known regarding how T-box factors regulate gene expression. The Caenorhabditis elegans genome contains 21 T-box genes, and their characterized functions include cell fate specification in a variety of tissues. The C. elegans Tbx1 sub-family member MLS-1 functions during larval development to specify the fate of non-striated uterine muscles; and, in mls-1 mutants, uterine muscles are transformed to a vulval muscle fate. Here we demonstrate that MLS-1 function depends on binding to the Groucho-family co-repressor UNC-37. MLS-1 interacts with UNC-37 via a conserved eh1 motif, and the MLS-1 eh1 motif is necessary for MLS-1 to specify uterine muscle fate. Moreover, unc-37 loss-of-function produces uterine muscle to vulval muscle fate transformation similar to those observed in mls-1 mutants. Based on these results, we conclude that MLS-1 specifies uterine muscle fate by repressing target gene expression, and this function depends on interaction with UNC-37. Moreover, we suggest that MLS-1 shares a common mechanism for transcriptional repression with related T-box factors in other animal phyla." @default.
• W2154276864 created "2016-06-24" @default.
• W2154276864 creator A5031078801 @default.
• W2154276864 creator A5086681504 @default.
• W2154276864 date "2011-08-11" @default.
• W2154276864 modified "2023-09-25" @default.
• W2154276864 title "The Caenorhabditis elegans T-Box Factor MLS-1 Requires Groucho Co-Repressor Interaction for Uterine Muscle Specification" @default.
• W2154276864 cites W1581412826 @default.
• W2154276864 cites W1835728047 @default.
• W2154276864 cites W1965169361 @default.
• W2154276864 cites W1968217129 @default.
• W2154276864 cites W1976987160 @default.
• W2154276864 cites W1985545096 @default.
• W2154276864 cites W1986006829 @default.
• W2154276864 cites W1995661863 @default.
• W2154276864 cites W2001028557 @default.
• W2154276864 cites W2002879092 @default.
• W2154276864 cites W2003038564 @default.
• W2154276864 cites W2012327898 @default.
• W2154276864 cites W2037877981 @default.
• W2154276864 cites W2041338073 @default.
• W2154276864 cites W2041399250 @default.
• W2154276864 cites W2045933397 @default.
• W2154276864 cites W2047311303 @default.
• W2154276864 cites W2060833609 @default.
• W2154276864 cites W2070341647 @default.
• W2154276864 cites W2072162746 @default.
• W2154276864 cites W2082692195 @default.
• W2154276864 cites W2104580844 @default.
• W2154276864 cites W2110353287 @default.
• W2154276864 cites W2122458935 @default.
• W2154276864 cites W2124478777 @default.
• W2154276864 cites W2132669667 @default.
• W2154276864 cites W2139782683 @default.
• W2154276864 cites W2142305917 @default.
• W2154276864 cites W2169706104 @default.
• W2154276864 cites W4295847395 @default.
• W2154276864 doi "https://doi.org/10.1371/journal.pgen.1002210" @default.
• W2154276864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3154951" @default.
• W2154276864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21852953" @default.
• W2154276864 hasPublicationYear "2011" @default.
• W2154276864 type Work @default.
• W2154276864 sameAs 2154276864 @default.
• W2154276864 citedByCount "6" @default.
• W2154276864 countsByYear W21542768642012 @default.
• W2154276864 countsByYear W21542768642013 @default.
• W2154276864 countsByYear W21542768642015 @default.
• W2154276864 countsByYear W21542768642016 @default.
• W2154276864 countsByYear W21542768642017 @default.
• W2154276864 crossrefType "journal-article" @default.
• W2154276864 hasAuthorship W2154276864A5031078801 @default.
• W2154276864 hasAuthorship W2154276864A5086681504 @default.
• W2154276864 hasBestOaLocation W21542768641 @default.
• W2154276864 hasConcept C101762097 @default.
• W2154276864 hasConcept C104317684 @default.
• W2154276864 hasConcept C143065580 @default.
• W2154276864 hasConcept C150194340 @default.
• W2154276864 hasConcept C158448853 @default.
• W2154276864 hasConcept C163952510 @default.
• W2154276864 hasConcept C186310378 @default.
• W2154276864 hasConcept C2778944004 @default.
• W2154276864 hasConcept C54355233 @default.
• W2154276864 hasConcept C68473852 @default.
• W2154276864 hasConcept C86339819 @default.
• W2154276864 hasConcept C86803240 @default.
• W2154276864 hasConcept C95444343 @default.
• W2154276864 hasConceptScore W2154276864C101762097 @default.
• W2154276864 hasConceptScore W2154276864C104317684 @default.
• W2154276864 hasConceptScore W2154276864C143065580 @default.
• W2154276864 hasConceptScore W2154276864C150194340 @default.
• W2154276864 hasConceptScore W2154276864C158448853 @default.
• W2154276864 hasConceptScore W2154276864C163952510 @default.
• W2154276864 hasConceptScore W2154276864C186310378 @default.
• W2154276864 hasConceptScore W2154276864C2778944004 @default.
• W2154276864 hasConceptScore W2154276864C54355233 @default.
• W2154276864 hasConceptScore W2154276864C68473852 @default.
• W2154276864 hasConceptScore W2154276864C86339819 @default.
• W2154276864 hasConceptScore W2154276864C86803240 @default.
• W2154276864 hasConceptScore W2154276864C95444343 @default.
• W2154276864 hasIssue "8" @default.
• W2154276864 hasLocation W21542768641 @default.
• W2154276864 hasLocation W21542768642 @default.
• W2154276864 hasLocation W21542768643 @default.
• W2154276864 hasLocation W21542768644 @default.
• W2154276864 hasLocation W21542768645 @default.
• W2154276864 hasOpenAccess W2154276864 @default.
• W2154276864 hasPrimaryLocation W21542768641 @default.
• W2154276864 hasRelatedWork W1805167287 @default.
• W2154276864 hasRelatedWork W1964656439 @default.
• W2154276864 hasRelatedWork W1982037464 @default.
• W2154276864 hasRelatedWork W1989108361 @default.
• W2154276864 hasRelatedWork W2007229537 @default.
• W2154276864 hasRelatedWork W2014198636 @default.
• W2154276864 hasRelatedWork W2033658269 @default.
• W2154276864 hasRelatedWork W2033932577 @default.
• W2154276864 hasRelatedWork W2040805319 @default.
• W2154276864 hasRelatedWork W2045933397 @default.
• W2154276864 hasRelatedWork W2070341647 @default.

• next