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- W2154284428 abstract "To investigate a possible increased risk of esophageal obstruction among users of loratadine and pseudoephedrine (Claritin-D 24-Hour [C-D 24], the original, round, extended-release formulation) compared to two other tablet formulations of loratadine.Pharmacy data of 12 managed care plans were screened to identify users in the three groups from 1 September 1996 to 31 December 1998. Users with a medical claim following their first loratadine prescription (Index prescription) indicating an esophageal obstruction or endoscopic procedure were considered claims-identified cases. Medical records were reviewed to validate case status.There were 233,901 users (61% female) and 245 claims-identified cases occurring within 30 days after the first prescription. The incidence rate per 10,000 users of claims-identified cases occurring on the Index prescription date was higher among C-D 24 users (IR = 1.4) than Claritin Regular (C-R) users (IR = 0.07; p < 0.002) or Claritin-D 12-Hour (C-D 12) users (IR = 0.3; p > 0.05). Medical record review of 15 claims-identified cases confirmed two cases of acute esophageal obstruction, both among C-D 24 users.Claims-based analysis suggested an increased risk of endoscopic procedures on the Index date among C-D 24 users compared to C-R users. However, after medical record review, the study did not provide conclusive evidence of an association between C-D 24 use and esophageal obstruction. This study highlights the importance of validating findings from claims data using medical records." @default.
- W2154284428 created "2016-06-24" @default.
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- W2154284428 date "2003-02-14" @default.
- W2154284428 modified "2023-09-25" @default.
- W2154284428 title "The risk of esophageal obstruction associated with an anti-allergy medication (Claritin-D® 24-Hour-original formulation)" @default.
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- W2154284428 doi "https://doi.org/10.1002/pds.816" @default.
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- W2154284428 hasPublicationYear "2003" @default.
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