FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154293072> ?p ?o ?g. }

• W2154293072 endingPage "1805" @default.
• W2154293072 startingPage "1796" @default.
• W2154293072 abstract "ABSTRACT Systemic immunization with antigen coupled to monoclonal antibody (MAb) has been used by several investigators to increase the number of MAb-producing hybridomas against an antigen and to elicit antibodies specific for poorly immunogenic epitopes. This strategy has implications for vaccine design in that protective immunity is not necessarily directed at immunodominant epitopes of pathogens and may be improved by deliberately shifting the immune response toward subdominant epitopes. To our knowledge, no studies to date have addressed the potential for immunomodulatory activity mediated by MAbs bound to mucosally applied antigen. To test whether administration of an exogenous MAb directed against a streptococcal surface protein could influence the humoral immune response, BALB/c mice were immunized orally by gastric intubation or intranasally with Streptococcus mutans alone or S. mutans complexed with a MAb directed against the major surface protein P1. Significant changes in the subclass distribution, as well as the specificity, of anti-P1 serum immunoglobulin G antibodies were demonstrated in groups of mice which received S. mutans coated with the anti-P1 MAb versus those which received S. mutans alone. Alterations in the humoral immune response were dependent on the amount of anti-P1 MAb used to coat the bacteria. In addition, differences in the anti-P1 immune responses were observed between groups of mice immunized via oral versus intranasal routes. In summary, an exogenous MAb complexed with a streptococcal antigen prior to mucosal immunization can influence the immunoglobulin isotype and specificity of the host humoral immune response against the antigen." @default.
• W2154293072 created "2016-06-24" @default.
• W2154293072 creator A5012752092 @default.
• W2154293072 creator A5017407791 @default.
• W2154293072 creator A5023164140 @default.
• W2154293072 creator A5076433513 @default.
• W2154293072 date "2000-04-01" @default.
• W2154293072 modified "2023-10-11" @default.
• W2154293072 title "Monoclonal Antibody-Mediated Modulation of the Humoral Immune Response against Mucosally Applied<i>Streptococcus mutans</i>" @default.
• W2154293072 cites W1524427538 @default.
• W2154293072 cites W1582658910 @default.
• W2154293072 cites W1696742755 @default.
• W2154293072 cites W1821656608 @default.
• W2154293072 cites W1839641018 @default.
• W2154293072 cites W1849092858 @default.
• W2154293072 cites W1856362873 @default.
• W2154293072 cites W1858935864 @default.
• W2154293072 cites W1870505889 @default.
• W2154293072 cites W1878759688 @default.
• W2154293072 cites W1900340311 @default.
• W2154293072 cites W1903369545 @default.
• W2154293072 cites W1906849390 @default.
• W2154293072 cites W1915401960 @default.
• W2154293072 cites W1922573479 @default.
• W2154293072 cites W1932950738 @default.
• W2154293072 cites W1934198871 @default.
• W2154293072 cites W1954541019 @default.
• W2154293072 cites W1964706714 @default.
• W2154293072 cites W1966561492 @default.
• W2154293072 cites W1968374266 @default.
• W2154293072 cites W1971202778 @default.
• W2154293072 cites W1971466426 @default.
• W2154293072 cites W1978790143 @default.
• W2154293072 cites W1980635642 @default.
• W2154293072 cites W1982839060 @default.
• W2154293072 cites W1983551146 @default.
• W2154293072 cites W1983756932 @default.
• W2154293072 cites W1984154523 @default.
• W2154293072 cites W1987880248 @default.
• W2154293072 cites W1988269292 @default.
• W2154293072 cites W1991522582 @default.
• W2154293072 cites W1992281042 @default.
• W2154293072 cites W1998645936 @default.
• W2154293072 cites W2001772358 @default.
• W2154293072 cites W2008408029 @default.
• W2154293072 cites W2013671168 @default.
• W2154293072 cites W2017145464 @default.
• W2154293072 cites W2018060065 @default.
• W2154293072 cites W2022564159 @default.
• W2154293072 cites W2023860116 @default.
• W2154293072 cites W2024612551 @default.
• W2154293072 cites W2028577426 @default.
• W2154293072 cites W2029625075 @default.
• W2154293072 cites W2041073620 @default.
• W2154293072 cites W2048151257 @default.
• W2154293072 cites W2049265450 @default.
• W2154293072 cites W2056903233 @default.
• W2154293072 cites W2058991170 @default.
• W2154293072 cites W2068583880 @default.
• W2154293072 cites W2075232330 @default.
• W2154293072 cites W2079206982 @default.
• W2154293072 cites W2080781566 @default.
• W2154293072 cites W2084385678 @default.
• W2154293072 cites W2085622549 @default.
• W2154293072 cites W2093009612 @default.
• W2154293072 cites W2095073858 @default.
• W2154293072 cites W2101031224 @default.
• W2154293072 cites W2104756061 @default.
• W2154293072 cites W2120636265 @default.
• W2154293072 cites W2122859063 @default.
• W2154293072 cites W2123029999 @default.
• W2154293072 cites W2126774514 @default.
• W2154293072 cites W2134440905 @default.
• W2154293072 cites W2140846495 @default.
• W2154293072 cites W2141234678 @default.
• W2154293072 cites W2142627742 @default.
• W2154293072 cites W2144656577 @default.
• W2154293072 cites W2148337956 @default.
• W2154293072 cites W2151317516 @default.
• W2154293072 cites W2151790962 @default.
• W2154293072 cites W2152932066 @default.
• W2154293072 cites W2155794730 @default.
• W2154293072 cites W2163196839 @default.
• W2154293072 cites W2164835119 @default.
• W2154293072 cites W2171117312 @default.
• W2154293072 cites W2292337439 @default.
• W2154293072 cites W2347581455 @default.
• W2154293072 cites W2408106242 @default.
• W2154293072 cites W4255171751 @default.
• W2154293072 cites W4313376466 @default.
• W2154293072 doi "https://doi.org/10.1128/iai.68.4.1796-1805.2000" @default.
• W2154293072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/97350" @default.
• W2154293072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10722566" @default.
• W2154293072 hasPublicationYear "2000" @default.
• W2154293072 type Work @default.
• W2154293072 sameAs 2154293072 @default.
• W2154293072 citedByCount "25" @default.
• W2154293072 countsByYear W21542930722012 @default.

• next