FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154294370> ?p ?o ?g. }

• W2154294370 endingPage "1156" @default.
• W2154294370 startingPage "1146" @default.
• W2154294370 abstract "Effective delivery of therapeutic agents to tumour cells is essential to the success of most cancer treatment therapies except for surgery. The transport of drug in solid tumours involves multiple biophysical and biochemical proc- esses which are strongly dependent on the physicochemical properties of the drug and biological properties of the tumour. Owing to the complexities involved, mathematical models are playing an increasingly important role in identifying the factors leading to inadequate drug delivery to tumours. In this study, a computational model is developed which incorpo- rates real tumour geometry reconstructed from magnetic resonance images, drug transport through the tumour vasculature and interstitium, as well as drug uptake by tumour cells. The effectiveness of anticancer therapy is evaluated based on the percentage of survival tumour cells by directly solving the pharmacodynamics equation using predicted intracellular drug concentrations. Computational simulations are performed for the delivery of doxorubicin through different administration modes and doses. Our predictions show that continuous infusion is far more effective than bolus injection in maintaining high levels of intracellular drug concentration, thereby increasing drug uptake by tumour cells. On the other hand, bolus injection leads to higher extracellular concentration in both tumour and normal tissues compared to continuous infusion, which is undesirable as high drug concentration in normal tissues may increase the risk of associated side effects. Keywords: Anticancer therapy, computational model, drug transport, MR image-based model, prostate tumour." @default.
• W2154294370 created "2016-06-24" @default.
• W2154294370 creator A5033357639 @default.
• W2154294370 creator A5043894683 @default.
• W2154294370 creator A5054301083 @default.
• W2154294370 date "2014-08-07" @default.
• W2154294370 modified "2023-09-25" @default.
• W2154294370 title "Mathematical Modelling of Drug Transport and Uptake in a Realistic Model of Solid Tumour" @default.
• W2154294370 cites W1516221483 @default.
• W2154294370 cites W1522090707 @default.
• W2154294370 cites W1581170315 @default.
• W2154294370 cites W1593844282 @default.
• W2154294370 cites W1751852575 @default.
• W2154294370 cites W1982369490 @default.
• W2154294370 cites W2000584529 @default.
• W2154294370 cites W2020732140 @default.
• W2154294370 cites W2029092471 @default.
• W2154294370 cites W2050940968 @default.
• W2154294370 cites W2052917365 @default.
• W2154294370 cites W2061060077 @default.
• W2154294370 cites W2062662242 @default.
• W2154294370 cites W2100411451 @default.
• W2154294370 cites W2104903940 @default.
• W2154294370 cites W2114595606 @default.
• W2154294370 cites W2120991581 @default.
• W2154294370 cites W2141766828 @default.
• W2154294370 cites W2143203694 @default.
• W2154294370 cites W2162763436 @default.
• W2154294370 cites W2170952917 @default.
• W2154294370 cites W2407400602 @default.
• W2154294370 cites W3168008081 @default.
• W2154294370 cites W67938392 @default.
• W2154294370 doi "https://doi.org/10.2174/0929866521666140807115629" @default.
• W2154294370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25106906" @default.
• W2154294370 hasPublicationYear "2014" @default.
• W2154294370 type Work @default.
• W2154294370 sameAs 2154294370 @default.
• W2154294370 citedByCount "16" @default.
• W2154294370 countsByYear W21542943702017 @default.
• W2154294370 countsByYear W21542943702018 @default.
• W2154294370 countsByYear W21542943702019 @default.
• W2154294370 countsByYear W21542943702020 @default.
• W2154294370 countsByYear W21542943702021 @default.
• W2154294370 countsByYear W21542943702022 @default.
• W2154294370 countsByYear W21542943702023 @default.
• W2154294370 crossrefType "journal-article" @default.
• W2154294370 hasAuthorship W2154294370A5033357639 @default.
• W2154294370 hasAuthorship W2154294370A5043894683 @default.
• W2154294370 hasAuthorship W2154294370A5054301083 @default.
• W2154294370 hasConcept C111113717 @default.
• W2154294370 hasConcept C112705442 @default.
• W2154294370 hasConcept C126322002 @default.
• W2154294370 hasConcept C126511603 @default.
• W2154294370 hasConcept C178790620 @default.
• W2154294370 hasConcept C185592680 @default.
• W2154294370 hasConcept C189165786 @default.
• W2154294370 hasConcept C2776694085 @default.
• W2154294370 hasConcept C2779820397 @default.
• W2154294370 hasConcept C2780035454 @default.
• W2154294370 hasConcept C2781303535 @default.
• W2154294370 hasConcept C28406088 @default.
• W2154294370 hasConcept C3018146709 @default.
• W2154294370 hasConcept C43376680 @default.
• W2154294370 hasConcept C502942594 @default.
• W2154294370 hasConcept C55493867 @default.
• W2154294370 hasConcept C71924100 @default.
• W2154294370 hasConcept C79879829 @default.
• W2154294370 hasConcept C98274493 @default.
• W2154294370 hasConceptScore W2154294370C111113717 @default.
• W2154294370 hasConceptScore W2154294370C112705442 @default.
• W2154294370 hasConceptScore W2154294370C126322002 @default.
• W2154294370 hasConceptScore W2154294370C126511603 @default.
• W2154294370 hasConceptScore W2154294370C178790620 @default.
• W2154294370 hasConceptScore W2154294370C185592680 @default.
• W2154294370 hasConceptScore W2154294370C189165786 @default.
• W2154294370 hasConceptScore W2154294370C2776694085 @default.
• W2154294370 hasConceptScore W2154294370C2779820397 @default.
• W2154294370 hasConceptScore W2154294370C2780035454 @default.
• W2154294370 hasConceptScore W2154294370C2781303535 @default.
• W2154294370 hasConceptScore W2154294370C28406088 @default.
• W2154294370 hasConceptScore W2154294370C3018146709 @default.
• W2154294370 hasConceptScore W2154294370C43376680 @default.
• W2154294370 hasConceptScore W2154294370C502942594 @default.
• W2154294370 hasConceptScore W2154294370C55493867 @default.
• W2154294370 hasConceptScore W2154294370C71924100 @default.
• W2154294370 hasConceptScore W2154294370C79879829 @default.
• W2154294370 hasConceptScore W2154294370C98274493 @default.
• W2154294370 hasIssue "11" @default.
• W2154294370 hasLocation W21542943701 @default.
• W2154294370 hasLocation W21542943702 @default.
• W2154294370 hasOpenAccess W2154294370 @default.
• W2154294370 hasPrimaryLocation W21542943701 @default.
• W2154294370 hasRelatedWork W1978032370 @default.
• W2154294370 hasRelatedWork W1979719945 @default.
• W2154294370 hasRelatedWork W1979757582 @default.
• W2154294370 hasRelatedWork W2090099591 @default.
• W2154294370 hasRelatedWork W2098168405 @default.
• W2154294370 hasRelatedWork W2332367370 @default.

• next