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• W2154314311 abstract "Maturation of the glutamatergic synapse is thought to require the incorporation of AMPA receptors at pure NMDA synapses, also called “silent” synapses. However, the relative number of silent synapses at different developmental stages, and even the concept that silent synapses lack AMPA receptors, is actively debated. In the present work, spontaneous synaptic events were used to investigate the relative contribution of synaptic AMPA and NMDA receptor-mediated transmission in CA1 pyramidal cells during the early postnatal development. Spontaneous postsynaptic currents, mediated by AMPA and NMDA receptors, were recorded from visualized CA1 pyramidal neurons over the first postnatal week. AMPA/NMDA ratio for frequency was close to one, and, importantly, it was constant over the first postnatal week. These findings suggest that the vast majority of nascent glutamatergic synapses express both functional AMPA and NMDA receptors in the neonatal hippocampus." @default.
• W2154314311 created "2016-06-24" @default.
• W2154314311 creator A5008288321 @default.
• W2154314311 creator A5040998161 @default.
• W2154314311 creator A5091837697 @default.
• W2154314311 date "2002-07-01" @default.
• W2154314311 modified "2023-10-18" @default.
• W2154314311 title "Spontaneous Unitary Synaptic Activity in CA1 Pyramidal Neurons during Early Postnatal Development: Constant Contribution of AMPA and NMDA Receptors" @default.
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• W2154314311 doi "https://doi.org/10.1523/jneurosci.22-13-05552.2002" @default.
• W2154314311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6758204" @default.
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