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- W2154319103 startingPage "16419" @default.
- W2154319103 abstract "A series of 5H-thiazolo[3,2-a]pyrimidin-5-ones were synthesized by the cyclization reactions of S-alkylated derivatives in concentrated H₂SO₄. Upon treatment of S-alkylated derivatives at different temperatures, intramolecular cyclization to 7-(substituted phenylamino)-5H-thiazolo[3,2-a]pyrimidin-5-ones or sulfonation of cyclized products to sulfonic acid derivatives occurred. The structures of the target compounds were confirmed by IR, ¹H-NMR, (13)C-NMR and HRMS studies. The compounds were evaluated for their preliminary in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria and screened for antitubercular activity against Mycobacterium tuberculosis by the broth dilution assay method. Some compounds showed good antibacterial and antitubercular activities." @default.
- W2154319103 created "2016-06-24" @default.
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- W2154319103 date "2015-09-10" @default.
- W2154319103 modified "2023-09-29" @default.
- W2154319103 title "Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives" @default.
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- W2154319103 doi "https://doi.org/10.3390/molecules200916419" @default.
- W2154319103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6332143" @default.
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