FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154331968> ?p ?o ?g. }

• W2154331968 endingPage "957" @default.
• W2154331968 startingPage "949" @default.
• W2154331968 abstract "Left ventricular (LV) hypertrophy and diastolic dysfunction, which are common cardiac consequences of hypertension, are modified by insulin resistance. The present study assessed the hypothesis that primary treatment of insulin resistance may reverse such cardiac changes in hypertensive patients.A total of 30 patients with essential hypertension were enrolled in this study. In echocardiographic examinations, LV mass index, the peak velocity ratio of early diastolic to atrial filling (E/A), and the E-wave deceleration time (DcT) were determined. Insulin sensitivity test with steady-state plasma glucose (SSPG) method, oral glucose tolerance test, and blood samplings for measurement of adiponectin and matrix metalloproteinase (MMP)-2 were also performed. Six months after treatment with pioglitazone (30 mg/day), an insulin sensitizer, these examinations were repeated.Pioglitazone significantly increased E/A and decreased DcT, without a change in LV mass index. These improvements in diastolic properties were much greater in subjects with a marked (>or==3.3 mmol/L) decrease in SSPG (n=11) than the others (n=19), although the decrease in glucose levels did not differ between the two groups. In addition, the changes in E/A and DcT were closely correlated with the decrease in SSPG. Pioglitazone treatment significantly elevated plasma adiponectin and MMP-2 levels, and the increase in MMP-2 was positively correlated with the increase in adiponectin.The present findings demonstrate that pioglitazone improves LV diastolic function without LV mass regression in hypertensive patients in proportion to the amelioration of insulin resistance. These findings suggest that increased adiponectin and MMP may be involved in the beneficial effect of pioglitazone on diastolic function." @default.
• W2154331968 created "2016-06-24" @default.
• W2154331968 creator A5013342731 @default.
• W2154331968 creator A5045905451 @default.
• W2154331968 creator A5047762669 @default.
• W2154331968 creator A5057690907 @default.
• W2154331968 creator A5063030973 @default.
• W2154331968 creator A5066393135 @default.
• W2154331968 creator A5071071101 @default.
• W2154331968 creator A5072909924 @default.
• W2154331968 creator A5074925904 @default.
• W2154331968 creator A5076422953 @default.
• W2154331968 creator A5080347210 @default.
• W2154331968 creator A5091467215 @default.
• W2154331968 date "2005-07-01" @default.
• W2154331968 modified "2023-10-16" @default.
• W2154331968 title "Pioglitazone Improves Left Ventricular Diastolic Function in Patients With Essential Hypertension" @default.
• W2154331968 cites W1964556266 @default.
• W2154331968 cites W1979496492 @default.
• W2154331968 cites W1980198526 @default.
• W2154331968 cites W1984636592 @default.
• W2154331968 cites W1985913315 @default.
• W2154331968 cites W1990601277 @default.
• W2154331968 cites W1995934832 @default.
• W2154331968 cites W2019225888 @default.
• W2154331968 cites W2022066415 @default.
• W2154331968 cites W2023097850 @default.
• W2154331968 cites W2025311714 @default.
• W2154331968 cites W2032884061 @default.
• W2154331968 cites W2056561246 @default.
• W2154331968 cites W2068134927 @default.
• W2154331968 cites W2078805041 @default.
• W2154331968 cites W2085095809 @default.
• W2154331968 cites W2086414722 @default.
• W2154331968 cites W2088258188 @default.
• W2154331968 cites W2098814823 @default.
• W2154331968 cites W2104041304 @default.
• W2154331968 cites W2104763662 @default.
• W2154331968 cites W2105809486 @default.
• W2154331968 cites W2112377527 @default.
• W2154331968 cites W2125385820 @default.
• W2154331968 cites W2126073175 @default.
• W2154331968 cites W2126109484 @default.
• W2154331968 cites W2131702141 @default.
• W2154331968 cites W2135606776 @default.
• W2154331968 cites W2136718447 @default.
• W2154331968 cites W2141222928 @default.
• W2154331968 cites W2142019270 @default.
• W2154331968 cites W2152926085 @default.
• W2154331968 cites W2164168171 @default.
• W2154331968 cites W2167767922 @default.
• W2154331968 cites W2317496803 @default.
• W2154331968 cites W2331304382 @default.
• W2154331968 cites W2335314371 @default.
• W2154331968 doi "https://doi.org/10.1016/j.amjhyper.2005.02.003" @default.
• W2154331968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16053992" @default.
• W2154331968 hasPublicationYear "2005" @default.
• W2154331968 type Work @default.
• W2154331968 sameAs 2154331968 @default.
• W2154331968 citedByCount "68" @default.
• W2154331968 countsByYear W21543319682012 @default.
• W2154331968 countsByYear W21543319682013 @default.
• W2154331968 countsByYear W21543319682014 @default.
• W2154331968 countsByYear W21543319682015 @default.
• W2154331968 countsByYear W21543319682016 @default.
• W2154331968 countsByYear W21543319682017 @default.
• W2154331968 countsByYear W21543319682018 @default.
• W2154331968 countsByYear W21543319682019 @default.
• W2154331968 countsByYear W21543319682020 @default.
• W2154331968 countsByYear W21543319682021 @default.
• W2154331968 crossrefType "journal-article" @default.
• W2154331968 hasAuthorship W2154331968A5013342731 @default.
• W2154331968 hasAuthorship W2154331968A5045905451 @default.
• W2154331968 hasAuthorship W2154331968A5047762669 @default.
• W2154331968 hasAuthorship W2154331968A5057690907 @default.
• W2154331968 hasAuthorship W2154331968A5063030973 @default.
• W2154331968 hasAuthorship W2154331968A5066393135 @default.
• W2154331968 hasAuthorship W2154331968A5071071101 @default.
• W2154331968 hasAuthorship W2154331968A5072909924 @default.
• W2154331968 hasAuthorship W2154331968A5074925904 @default.
• W2154331968 hasAuthorship W2154331968A5076422953 @default.
• W2154331968 hasAuthorship W2154331968A5080347210 @default.
• W2154331968 hasAuthorship W2154331968A5091467215 @default.
• W2154331968 hasBestOaLocation W21543319681 @default.
• W2154331968 hasConcept C126322002 @default.
• W2154331968 hasConcept C134018914 @default.
• W2154331968 hasConcept C164705383 @default.
• W2154331968 hasConcept C2776002628 @default.
• W2154331968 hasConcept C2776782570 @default.
• W2154331968 hasConcept C2777180221 @default.
• W2154331968 hasConcept C2777391703 @default.
• W2154331968 hasConcept C2778384471 @default.
• W2154331968 hasConcept C2779306644 @default.
• W2154331968 hasConcept C2780221984 @default.
• W2154331968 hasConcept C555293320 @default.
• W2154331968 hasConcept C57900726 @default.
• W2154331968 hasConcept C71924100 @default.
• W2154331968 hasConcept C84393581 @default.

• next