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• W2154345169 abstract "The design and synthesis of a novel series of potent and cell permeable peptidomimetic inhibitors of the human beta-secretase (BACE) are described. These inhibitors feature a hydroxyethyl secondary amine isostere and a novel aromatic ring replacement for the C-terminus. The crystal structure of BACE in complex with this hydroxyethyl secondary amine isostere inhibitor is also presented." @default.
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• W2154345169 date "2007-01-10" @default.
• W2154345169 modified "2023-10-14" @default.
• W2154345169 title "Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase" @default.
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• W2154345169 doi "https://doi.org/10.1021/jm061242y" @default.
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