FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154357554> ?p ?o ?g. }

• W2154357554 endingPage "6087" @default.
• W2154357554 startingPage "6080" @default.
• W2154357554 abstract "Abstract The ACTH receptor (ACTH-R) is the second member of the melanocortin (MC-2) receptor family that includes five seven-transmembrane G protein-coupled receptors and has been shown to be predominantly expressed in the adrenal cortex. It has been postulated that ACTH may regulate its own secretion through ultra-short-loop feedback within the pituitary. ACTH-secreting adenomas are characterized by resistance to glucocorticoid feedback, and they may have dysregulated ACTH feedback. We therefore investigated the ACTH-R in normal and adenomatous human pituitary tissue. We report here the identification of ACTH-R mRNA in the human pituitary gland, which was confirmed by direct sequencing. We studied the expression of the ACTH-R in 23 normal pituitary specimens and 53 pituitary adenomas (22 ACTH-secreting, nine GH-secreting, eight prolactin-secreting, one TSH-secreting, one FSH-secreting, 10 nonfunctioning, and two silent corticotroph adenomas), using the sensitive technique of real-time quantitative PCR. Contamination of ACTH-secreting adenomas and nonfunctioning pituitary adenomas with nonadenomatous tissue was excluded by lack of Pit-1 expression. ACTH-R mRNA was detected in all normal pituitary specimens, and in situ hybridization colocalized expression to ACTH staining cells only. However, ACTH-R mRNA levels were undetectable in 16 of 22 ACTH-secreting tumors and in both silent corticotroph tumors. Diagnostic preoperative plasma ACTH levels were significantly lower in the ACTH-R positive ACTH-secreting tumors, compared with those who were ACTH-R negative (P = 0.0006). Direct sequencing of the coding region of the ACTH-R in cDNA from three ACTH-secreting tumors positively expressing the receptor showed no mutations, as did sequencing of genomic DNA in three receptor negative ACTH-secreting tumors and the two silent corticotrophs. These results provide further evidence compatible with an ACTH feedback loop in the pituitary and suggest that loss of expression of the ACTH-R in corticotroph adenomas of patients with Cushing’s disease may play a role in the resistance to feedback of the pituitary-adrenal axis seen in these patients." @default.
• W2154357554 created "2016-06-24" @default.
• W2154357554 creator A5011111877 @default.
• W2154357554 creator A5017519053 @default.
• W2154357554 creator A5030447992 @default.
• W2154357554 creator A5037557664 @default.
• W2154357554 creator A5044526995 @default.
• W2154357554 creator A5046852415 @default.
• W2154357554 creator A5049682377 @default.
• W2154357554 creator A5059394861 @default.
• W2154357554 creator A5064285421 @default.
• W2154357554 creator A5064393748 @default.
• W2154357554 creator A5068485918 @default.
• W2154357554 creator A5076490684 @default.
• W2154357554 creator A5078697024 @default.
• W2154357554 creator A5081126625 @default.
• W2154357554 creator A5082068718 @default.
• W2154357554 date "2003-12-01" @default.
• W2154357554 modified "2023-10-18" @default.
• W2154357554 title "Identification of Adrenocorticotropin Receptor Messenger Ribonucleic Acid in the Human Pituitary and Its Loss of Expression in Pituitary Adenomas" @default.
• W2154357554 cites W1556820154 @default.
• W2154357554 cites W1964718638 @default.
• W2154357554 cites W1970614438 @default.
• W2154357554 cites W1972876951 @default.
• W2154357554 cites W1979420492 @default.
• W2154357554 cites W1984051335 @default.
• W2154357554 cites W1991848396 @default.
• W2154357554 cites W1998001019 @default.
• W2154357554 cites W2002527589 @default.
• W2154357554 cites W2007771148 @default.
• W2154357554 cites W2015556277 @default.
• W2154357554 cites W2024596477 @default.
• W2154357554 cites W2032827821 @default.
• W2154357554 cites W2046106422 @default.
• W2154357554 cites W2055723678 @default.
• W2154357554 cites W2062835929 @default.
• W2154357554 cites W2077224224 @default.
• W2154357554 cites W2078937608 @default.
• W2154357554 cites W2081103194 @default.
• W2154357554 cites W2085426680 @default.
• W2154357554 cites W2097884682 @default.
• W2154357554 cites W2117535295 @default.
• W2154357554 cites W2121594137 @default.
• W2154357554 doi "https://doi.org/10.1210/jc.2002-022048" @default.
• W2154357554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14671214" @default.
• W2154357554 hasPublicationYear "2003" @default.
• W2154357554 type Work @default.
• W2154357554 sameAs 2154357554 @default.
• W2154357554 citedByCount "45" @default.
• W2154357554 countsByYear W21543575542012 @default.
• W2154357554 countsByYear W21543575542013 @default.
• W2154357554 countsByYear W21543575542014 @default.
• W2154357554 countsByYear W21543575542015 @default.
• W2154357554 countsByYear W21543575542016 @default.
• W2154357554 countsByYear W21543575542017 @default.
• W2154357554 countsByYear W21543575542023 @default.
• W2154357554 crossrefType "journal-article" @default.
• W2154357554 hasAuthorship W2154357554A5011111877 @default.
• W2154357554 hasAuthorship W2154357554A5017519053 @default.
• W2154357554 hasAuthorship W2154357554A5030447992 @default.
• W2154357554 hasAuthorship W2154357554A5037557664 @default.
• W2154357554 hasAuthorship W2154357554A5044526995 @default.
• W2154357554 hasAuthorship W2154357554A5046852415 @default.
• W2154357554 hasAuthorship W2154357554A5049682377 @default.
• W2154357554 hasAuthorship W2154357554A5059394861 @default.
• W2154357554 hasAuthorship W2154357554A5064285421 @default.
• W2154357554 hasAuthorship W2154357554A5064393748 @default.
• W2154357554 hasAuthorship W2154357554A5068485918 @default.
• W2154357554 hasAuthorship W2154357554A5076490684 @default.
• W2154357554 hasAuthorship W2154357554A5078697024 @default.
• W2154357554 hasAuthorship W2154357554A5081126625 @default.
• W2154357554 hasAuthorship W2154357554A5082068718 @default.
• W2154357554 hasBestOaLocation W21543575541 @default.
• W2154357554 hasConcept C126322002 @default.
• W2154357554 hasConcept C134018914 @default.
• W2154357554 hasConcept C170493617 @default.
• W2154357554 hasConcept C177865409 @default.
• W2154357554 hasConcept C2777428134 @default.
• W2154357554 hasConcept C2777658017 @default.
• W2154357554 hasConcept C2779029589 @default.
• W2154357554 hasConcept C2779318953 @default.
• W2154357554 hasConcept C2780546910 @default.
• W2154357554 hasConcept C2781449511 @default.
• W2154357554 hasConcept C2908910360 @default.
• W2154357554 hasConcept C71315377 @default.
• W2154357554 hasConcept C71924100 @default.
• W2154357554 hasConcept C79381400 @default.
• W2154357554 hasConcept C86803240 @default.
• W2154357554 hasConceptScore W2154357554C126322002 @default.
• W2154357554 hasConceptScore W2154357554C134018914 @default.
• W2154357554 hasConceptScore W2154357554C170493617 @default.
• W2154357554 hasConceptScore W2154357554C177865409 @default.
• W2154357554 hasConceptScore W2154357554C2777428134 @default.
• W2154357554 hasConceptScore W2154357554C2777658017 @default.
• W2154357554 hasConceptScore W2154357554C2779029589 @default.
• W2154357554 hasConceptScore W2154357554C2779318953 @default.
• W2154357554 hasConceptScore W2154357554C2780546910 @default.
• W2154357554 hasConceptScore W2154357554C2781449511 @default.

• next