FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154362045> ?p ?o ?g. }

• W2154362045 endingPage "7" @default.
• W2154362045 startingPage "1131" @default.
• W2154362045 abstract "The launch of the cyclooxygenase-2 (COX-2) selective NSAIDs was based on 2 hypotheses: (1) the major adverse effects limiting the usefulness of nonselective NSAIDs are gastrointestinal in nature and (2) COX-2 selective NSAIDs are associated with fewer gastrointestinal adverse effects than nonselective NSAIDs. At the time of the launch, neither of these hypotheses had been proven and, as documented in this review, both remain uncertain. The increased incidence of total and nongastrointestinal serious adverse events, with the COX-2 selective NSAIDs as compared with nonselective NSAIDs, in the Celecoxib Long-term Arthritis Safety Study (CLASS) and the Vioxx Gastrointestinal Outcomes Research (VIGOR) study remains a major concern. The increased morbidity associated with the COX-2 selective NSAIDs may be a manifestation of the COX-2 selectivity of rofecoxib and celecoxib or the supramaximal doses of these drugs used in the trials. Proof that the increased harm was not caused by the COX-2 selectivity of the drugs depends on demonstration in a randomized controlled trial that COX-2 selective NSAIDs at usual doses are as effective as nonselective NSAIDs and cause fewer gastrointestinal serious adverse events without increasing the incidence of total nongastrointestinal serious adverse events." @default.
• W2154362045 created "2016-06-24" @default.
• W2154362045 creator A5051166300 @default.
• W2154362045 date "2002-11-12" @default.
• W2154362045 modified "2023-09-28" @default.
• W2154362045 title "The double-edged sword of COX-2 selective NSAIDs." @default.
• W2154362045 cites W1480729244 @default.
• W2154362045 cites W1486263930 @default.
• W2154362045 cites W1539392991 @default.
• W2154362045 cites W165356651 @default.
• W2154362045 cites W1748665159 @default.
• W2154362045 cites W1977473142 @default.
• W2154362045 cites W1983104516 @default.
• W2154362045 cites W1983370454 @default.
• W2154362045 cites W1993398606 @default.
• W2154362045 cites W1998213501 @default.
• W2154362045 cites W2001162433 @default.
• W2154362045 cites W2018716226 @default.
• W2154362045 cites W2020563114 @default.
• W2154362045 cites W2024233889 @default.
• W2154362045 cites W2024352468 @default.
• W2154362045 cites W2028772712 @default.
• W2154362045 cites W2034468337 @default.
• W2154362045 cites W2038410983 @default.
• W2154362045 cites W2039149640 @default.
• W2154362045 cites W2115679325 @default.
• W2154362045 cites W2118794261 @default.
• W2154362045 cites W2125003309 @default.
• W2154362045 cites W2138974113 @default.
• W2154362045 cites W2145816148 @default.
• W2154362045 cites W2160703991 @default.
• W2154362045 cites W2163756514 @default.
• W2154362045 cites W2164878356 @default.
• W2154362045 cites W2330496155 @default.
• W2154362045 cites W2414786594 @default.
• W2154362045 cites W2519935593 @default.
• W2154362045 cites W2725056820 @default.
• W2154362045 cites W4240442341 @default.
• W2154362045 cites W75297534 @default.
• W2154362045 cites W97893626 @default.
• W2154362045 cites W1644577377 @default.
• W2154362045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/134294" @default.
• W2154362045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12427705" @default.
• W2154362045 hasPublicationYear "2002" @default.
• W2154362045 type Work @default.
• W2154362045 sameAs 2154362045 @default.
• W2154362045 citedByCount "70" @default.
• W2154362045 countsByYear W21543620452012 @default.
• W2154362045 countsByYear W21543620452013 @default.
• W2154362045 countsByYear W21543620452014 @default.
• W2154362045 countsByYear W21543620452015 @default.
• W2154362045 countsByYear W21543620452016 @default.
• W2154362045 countsByYear W21543620452018 @default.
• W2154362045 countsByYear W21543620452019 @default.
• W2154362045 countsByYear W21543620452020 @default.
• W2154362045 countsByYear W21543620452021 @default.
• W2154362045 countsByYear W21543620452023 @default.
• W2154362045 crossrefType "journal-article" @default.
• W2154362045 hasAuthorship W2154362045A5051166300 @default.
• W2154362045 hasConcept C120665830 @default.
• W2154362045 hasConcept C121332964 @default.
• W2154362045 hasConcept C126322002 @default.
• W2154362045 hasConcept C181199279 @default.
• W2154362045 hasConcept C185592680 @default.
• W2154362045 hasConcept C197934379 @default.
• W2154362045 hasConcept C2776467144 @default.
• W2154362045 hasConcept C2777031258 @default.
• W2154362045 hasConcept C2778582115 @default.
• W2154362045 hasConcept C2779689624 @default.
• W2154362045 hasConcept C55493867 @default.
• W2154362045 hasConcept C61511704 @default.
• W2154362045 hasConcept C71924100 @default.
• W2154362045 hasConcept C98274493 @default.
• W2154362045 hasConceptScore W2154362045C120665830 @default.
• W2154362045 hasConceptScore W2154362045C121332964 @default.
• W2154362045 hasConceptScore W2154362045C126322002 @default.
• W2154362045 hasConceptScore W2154362045C181199279 @default.
• W2154362045 hasConceptScore W2154362045C185592680 @default.
• W2154362045 hasConceptScore W2154362045C197934379 @default.
• W2154362045 hasConceptScore W2154362045C2776467144 @default.
• W2154362045 hasConceptScore W2154362045C2777031258 @default.
• W2154362045 hasConceptScore W2154362045C2778582115 @default.
• W2154362045 hasConceptScore W2154362045C2779689624 @default.
• W2154362045 hasConceptScore W2154362045C55493867 @default.
• W2154362045 hasConceptScore W2154362045C61511704 @default.
• W2154362045 hasConceptScore W2154362045C71924100 @default.
• W2154362045 hasConceptScore W2154362045C98274493 @default.
• W2154362045 hasIssue "10" @default.
• W2154362045 hasLocation W21543620451 @default.
• W2154362045 hasOpenAccess W2154362045 @default.
• W2154362045 hasPrimaryLocation W21543620451 @default.
• W2154362045 hasRelatedWork W156805900 @default.
• W2154362045 hasRelatedWork W1991307214 @default.
• W2154362045 hasRelatedWork W2053833211 @default.
• W2154362045 hasRelatedWork W2084602324 @default.
• W2154362045 hasRelatedWork W2154362045 @default.
• W2154362045 hasRelatedWork W2162216950 @default.
• W2154362045 hasRelatedWork W2411901332 @default.

• next