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- W2154362351 abstract "Background and objectives: Anemia Management Protocols in ESRD call for hemoglobin (Hb) monitoring every 2 to 4 weeks. Short-term Hb variability affects the reliability of Hb measurement and may lead to incorrect dosing of erythropoiesis stimulating agents. We prospectively analyzed short-term Hb variability and quantified the relationship between frequency of Hb monitoring and error in Hb estimation. Design, setting, participants, & measurements: Using the Crit-Line III TQA device, we prospectively observed Hb during each dialysis treatment in 49 ESRD patients and quantified long- and short-term Hb variability. We estimated Hb from data sampled at regular intervals; 8×, 4×, 2×, or 1× per month to establish how well we account for short-term variability at different monitoring intervals. We calculated the Hb estimation error (Hberr) as a root mean-squared difference between the observed and estimated Hb and compared it with the measurement error. Results: The most accurate Hb estimation is achieved when monitoring 8× per month (Hberr = 0.23 ± 0.05 g/dl), but it exceeds the accuracy of the measurement device. The estimation error increases to 0.34 ± 0.07 g/dl when monitoring 4× per month, 0.39 ± 0.08 g/dl when monitoring 2× a month, and 0.45 ± 0.09 g/dl when monitoring 1× per month. Estimation error comparable to instrument error information is as follows: 8× per month, 15 patients; 4× per month, 22 patients; 2× per month, 6 patients; 1× per a month, 6 patients. Conclusions: Four times a month is the clinically optimal Hb monitoring frequency for anemia management." @default.
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- W2154362351 date "2010-11-01" @default.
- W2154362351 modified "2023-10-15" @default.
- W2154362351 title "Determining Optimum Hemoglobin Sampling for Anemia Management from Every-Treatment Data" @default.
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- W2154362351 doi "https://doi.org/10.2215/cjn.03540410" @default.
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