Matches in SemOpenAlex for { <https://semopenalex.org/work/W21543673> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W21543673 endingPage "50" @default.
- W21543673 startingPage "541" @default.
- W21543673 abstract "Tricyclic antidepressants (TCAs) taken in large quantities during suicide attempts have altered pharmacokinetics. Their absorption may be delayed by inhibition of gastric emptying and peristalsis. A significant enterohepatic recirculation delays final elimination of a large fraction of the drug. The enzymes responsible for TCA benzyl-hydroxylation can become saturated and thus reduce TCA elimination to zero-order kinetics. TCA unbound to plasma proteins may also increase because of an acidemia resulting from a respiratory depression after overdose. Other compounds are ingested in suicide attempts which greatly change TCA pharmacokinetics. Metabolism of ethanol generates an excess of reducing equivalents which inhibit TCA oxidative metabolism. Neuroleptics directly inhibit TCA hydroxylation. Fluoxetine significantly prolongs elimination and increases plasma levels of TCA. Toxic hepatic metabolites of acetaminophen would delay TCA elimination. The elderly have slower rates of drug elimination and are particularly susceptible to TCA antidepressants taken in overdose." @default.
- W21543673 created "2016-06-24" @default.
- W21543673 creator A5034664985 @default.
- W21543673 date "1991-01-01" @default.
- W21543673 modified "2023-10-18" @default.
- W21543673 title "Clinical pharmacokinetics of tricyclic antidepressant overdose." @default.
- W21543673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1813901" @default.
- W21543673 hasPublicationYear "1991" @default.
- W21543673 type Work @default.
- W21543673 sameAs 21543673 @default.
- W21543673 citedByCount "18" @default.
- W21543673 countsByYear W215436732016 @default.
- W21543673 countsByYear W215436732017 @default.
- W21543673 countsByYear W215436732019 @default.
- W21543673 countsByYear W215436732023 @default.
- W21543673 crossrefType "journal-article" @default.
- W21543673 hasAuthorship W21543673A5034664985 @default.
- W21543673 hasConcept C112705442 @default.
- W21543673 hasConcept C134018914 @default.
- W21543673 hasConcept C181199279 @default.
- W21543673 hasConcept C185592680 @default.
- W21543673 hasConcept C2778620825 @default.
- W21543673 hasConcept C2778722691 @default.
- W21543673 hasConcept C2779177272 @default.
- W21543673 hasConcept C2779657639 @default.
- W21543673 hasConcept C2780035454 @default.
- W21543673 hasConcept C2781081902 @default.
- W21543673 hasConcept C2781109383 @default.
- W21543673 hasConcept C2781161787 @default.
- W21543673 hasConcept C55493867 @default.
- W21543673 hasConcept C62231903 @default.
- W21543673 hasConcept C71924100 @default.
- W21543673 hasConcept C98274493 @default.
- W21543673 hasConceptScore W21543673C112705442 @default.
- W21543673 hasConceptScore W21543673C134018914 @default.
- W21543673 hasConceptScore W21543673C181199279 @default.
- W21543673 hasConceptScore W21543673C185592680 @default.
- W21543673 hasConceptScore W21543673C2778620825 @default.
- W21543673 hasConceptScore W21543673C2778722691 @default.
- W21543673 hasConceptScore W21543673C2779177272 @default.
- W21543673 hasConceptScore W21543673C2779657639 @default.
- W21543673 hasConceptScore W21543673C2780035454 @default.
- W21543673 hasConceptScore W21543673C2781081902 @default.
- W21543673 hasConceptScore W21543673C2781109383 @default.
- W21543673 hasConceptScore W21543673C2781161787 @default.
- W21543673 hasConceptScore W21543673C55493867 @default.
- W21543673 hasConceptScore W21543673C62231903 @default.
- W21543673 hasConceptScore W21543673C71924100 @default.
- W21543673 hasConceptScore W21543673C98274493 @default.
- W21543673 hasIssue "4" @default.
- W21543673 hasLocation W215436731 @default.
- W21543673 hasOpenAccess W21543673 @default.
- W21543673 hasPrimaryLocation W215436731 @default.
- W21543673 hasRelatedWork W1915885915 @default.
- W21543673 hasRelatedWork W1993534000 @default.
- W21543673 hasRelatedWork W2017238790 @default.
- W21543673 hasRelatedWork W2019666798 @default.
- W21543673 hasRelatedWork W2055433027 @default.
- W21543673 hasRelatedWork W2066889739 @default.
- W21543673 hasRelatedWork W2070715876 @default.
- W21543673 hasRelatedWork W2080907754 @default.
- W21543673 hasRelatedWork W2416691708 @default.
- W21543673 hasRelatedWork W42081348 @default.
- W21543673 hasVolume "27" @default.
- W21543673 isParatext "false" @default.
- W21543673 isRetracted "false" @default.
- W21543673 magId "21543673" @default.
- W21543673 workType "article" @default.