FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154371721> ?p ?o ?g. }

• W2154371721 endingPage "52" @default.
• W2154371721 startingPage "45" @default.
• W2154371721 abstract "Abstract The trabecular meshwork (TM), a specialized eye tissue, is a major site for regulation of the aqueous humor outflow. Malfunctioning of this tissue is believed to be responsible for development of glaucoma, a blinding disease. Myocilin is a gene linked to the most common form of glaucoma. The protein product has been localized to both intra and extracellular sites, but its function still remains unclear. This study was to determine whether extracellular myocilin presented in the matrix affects adhesion, morphology, and migratory and phagocytic activities of human TM cells in culture. Cell adhesion assays indicated that TM cells, while adhering readily on fibronectin, failed to attach on recombinant myocilin purified from bacterial cultures. Adhesion on fibronectin was also compromised by myocilin in a dose dependent manner. Myocilin in addition triggered TM cells to assume a stellate appearance with broad cell bodies and microspikes. Loss of actin stress fibers and focal adhesions was observed. TM cell migration on fibronectin/myocilin to scratched wounds was reduced compared to fibronectin controls. Myocilin, however, had little impact on phagocytic activities of TM cells. Cell attachment on fibronectin and migration of corneal fibroblasts, a control cell type, were not altered by myocilin. These results demonstrate that extracellular myocilin elicits anti‐adhesive and counter‐migratory effects on TM cells. Myocilin in the matrix of tissues could be exerting a similar influence on TM cells in vivo, impacting the flexibility and resilience required for maintenance of the normal aqueous outflow. © 2004 Wiley‐Liss, Inc." @default.
• W2154371721 created "2016-06-24" @default.
• W2154371721 creator A5038443879 @default.
• W2154371721 creator A5045591905 @default.
• W2154371721 creator A5049842101 @default.
• W2154371721 creator A5064435573 @default.
• W2154371721 date "2004-02-17" @default.
• W2154371721 modified "2023-10-16" @default.
• W2154371721 title "Extracellular myocilin affects activity of human trabecular meshwork cells" @default.
• W2154371721 cites W1594278877 @default.
• W2154371721 cites W1941119820 @default.
• W2154371721 cites W1971485090 @default.
• W2154371721 cites W1973020985 @default.
• W2154371721 cites W1976500011 @default.
• W2154371721 cites W1985550180 @default.
• W2154371721 cites W1986792037 @default.
• W2154371721 cites W2001792122 @default.
• W2154371721 cites W2028671736 @default.
• W2154371721 cites W2030835960 @default.
• W2154371721 cites W2031214260 @default.
• W2154371721 cites W2031264242 @default.
• W2154371721 cites W2038763647 @default.
• W2154371721 cites W2041096128 @default.
• W2154371721 cites W2054113978 @default.
• W2154371721 cites W2054271337 @default.
• W2154371721 cites W2054380928 @default.
• W2154371721 cites W2064417092 @default.
• W2154371721 cites W2068728134 @default.
• W2154371721 cites W2069522096 @default.
• W2154371721 cites W2071647588 @default.
• W2154371721 cites W2072365851 @default.
• W2154371721 cites W2079080309 @default.
• W2154371721 cites W2084340179 @default.
• W2154371721 cites W2086989005 @default.
• W2154371721 cites W2088651192 @default.
• W2154371721 cites W2089580105 @default.
• W2154371721 cites W2094977103 @default.
• W2154371721 cites W2100159037 @default.
• W2154371721 cites W2110310702 @default.
• W2154371721 cites W2115491755 @default.
• W2154371721 cites W2122434993 @default.
• W2154371721 cites W2127145280 @default.
• W2154371721 cites W2130763839 @default.
• W2154371721 cites W2133989466 @default.
• W2154371721 cites W2143204111 @default.
• W2154371721 cites W2155059288 @default.
• W2154371721 cites W2158527573 @default.
• W2154371721 cites W2160566735 @default.
• W2154371721 cites W2183079276 @default.
• W2154371721 cites W2404271118 @default.
• W2154371721 cites W2946176922 @default.
• W2154371721 cites W34966227 @default.
• W2154371721 doi "https://doi.org/10.1002/jcp.10478" @default.
• W2154371721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15137056" @default.
• W2154371721 hasPublicationYear "2004" @default.
• W2154371721 type Work @default.
• W2154371721 sameAs 2154371721 @default.
• W2154371721 citedByCount "68" @default.
• W2154371721 countsByYear W21543717212012 @default.
• W2154371721 countsByYear W21543717212013 @default.
• W2154371721 countsByYear W21543717212014 @default.
• W2154371721 countsByYear W21543717212016 @default.
• W2154371721 countsByYear W21543717212017 @default.
• W2154371721 countsByYear W21543717212018 @default.
• W2154371721 countsByYear W21543717212020 @default.
• W2154371721 countsByYear W21543717212021 @default.
• W2154371721 countsByYear W21543717212022 @default.
• W2154371721 countsByYear W21543717212023 @default.
• W2154371721 crossrefType "journal-article" @default.
• W2154371721 hasAuthorship W2154371721A5038443879 @default.
• W2154371721 hasAuthorship W2154371721A5045591905 @default.
• W2154371721 hasAuthorship W2154371721A5049842101 @default.
• W2154371721 hasAuthorship W2154371721A5064435573 @default.
• W2154371721 hasConcept C1491633281 @default.
• W2154371721 hasConcept C169760540 @default.
• W2154371721 hasConcept C185592680 @default.
• W2154371721 hasConcept C189165786 @default.
• W2154371721 hasConcept C2778527774 @default.
• W2154371721 hasConcept C2781121420 @default.
• W2154371721 hasConcept C2781147369 @default.
• W2154371721 hasConcept C28406088 @default.
• W2154371721 hasConcept C55493867 @default.
• W2154371721 hasConcept C86492073 @default.
• W2154371721 hasConcept C86803240 @default.
• W2154371721 hasConcept C95444343 @default.
• W2154371721 hasConceptScore W2154371721C1491633281 @default.
• W2154371721 hasConceptScore W2154371721C169760540 @default.
• W2154371721 hasConceptScore W2154371721C185592680 @default.
• W2154371721 hasConceptScore W2154371721C189165786 @default.
• W2154371721 hasConceptScore W2154371721C2778527774 @default.
• W2154371721 hasConceptScore W2154371721C2781121420 @default.
• W2154371721 hasConceptScore W2154371721C2781147369 @default.
• W2154371721 hasConceptScore W2154371721C28406088 @default.
• W2154371721 hasConceptScore W2154371721C55493867 @default.
• W2154371721 hasConceptScore W2154371721C86492073 @default.
• W2154371721 hasConceptScore W2154371721C86803240 @default.
• W2154371721 hasConceptScore W2154371721C95444343 @default.
• W2154371721 hasIssue "1" @default.

• next