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- W2154381946 abstract "Trichilia hirta L. (Meliaceae) is traditionally used as antitumor source in Santiago de Cuba. Therefore, the aim of this study was to document and analyze the traditional medicinal use of this plant by cancer patients in Santiago de Cuba and to evaluate its antiproliferative activity on human normal and cancer cells. Cancer patients consuming Trichilia hirta extracts (Jubaban) were randomly selected and interviewed. The antiproliferative activity of a polysaccharide-rich fraction from leaves was evaluated against normal (MRC-5) and cancer cells (A-549, HeLa and Hep-2) by MTT assay. The study revealed that Trichilia hirta extracts are mainly used as anticancer source (46%). Moreover, the majority of cancer patients consuming Trichilia hirta extracts had carcinoma (86%). In particular, the most frequent were lung (26%) and prostate (18%) carcinoma. The majority (90%) of patients were consuming the extracts simultaneously, or after the chemotherapy and radiotherapy treatment. The polysaccharide-rich fraction showed antiproliferative activity against human lung cancer cells (A549) and human cervix carcinoma (HeLa) cancer cells. However, no toxicity was observed in human normal fibroblasts (MRC-5). These results suggest that polysaccharide-rich fraction from Trichilia hirta contribute to the antitumor properties of this specie." @default.
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- W2154381946 date "2013-01-01" @default.
- W2154381946 modified "2023-09-23" @default.
- W2154381946 title "Ethnopharmacological evaluation of Trichilia hirta L. as anticancer source in traditional medicine of Santiago de Cuba" @default.
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