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- W2154382135 abstract "Abstract Bacterial formyl‐CoA:oxalate CoA‐transferase (FCOCT) and oxalyl‐CoA decarboxylase work in tandem to perform a proton‐consuming decarboxylation that has been suggested to have a role in generalized acid resistance. FCOCT is the product of uctB in the acidophilic acetic acid bacterium Acetobacter aceti . As expected for an acid‐resistance factor, UctB remains folded at the low pH values encountered in the A. aceti cytoplasm. A comparison of crystal structures of FCOCTs and related proteins revealed few features in UctB that would distinguish it from nonacidophilic proteins and thereby account for its acid stability properties, other than a strikingly featureless electrostatic surface. The apparently neutral surface is a result of a “speckled” charge decoration, in which charged surface residues are surrounded by compensating charges but do not form salt bridges. A quantitative comparison among orthologs identified a pattern of residue substitution in UctB that may be a consequence of selection for protein stability by constant exposure to acetic acid. We suggest that this surface charge pattern, which is a distinctive feature of A. aceti proteins, creates a stabilizing electrostatic network without stiffening the protein or compromising protein–solvent interactions." @default.
- W2154382135 created "2016-06-24" @default.
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- W2154382135 date "2012-03-29" @default.
- W2154382135 modified "2023-10-16" @default.
- W2154382135 title "Formyl-coenzyme A (CoA):oxalate CoA-transferase from the acidophile <i>Acetobacter aceti</i> has a distinctive electrostatic surface and inherent acid stability" @default.
- W2154382135 cites W1485645868 @default.
- W2154382135 cites W1554168735 @default.
- W2154382135 cites W1592527426 @default.
- W2154382135 cites W1812709225 @default.
- W2154382135 cites W1965151258 @default.
- W2154382135 cites W1973940014 @default.
- W2154382135 cites W1974467642 @default.
- W2154382135 cites W1978096114 @default.
- W2154382135 cites W1978870059 @default.
- W2154382135 cites W1985629904 @default.
- W2154382135 cites W1987304634 @default.
- W2154382135 cites W1990598235 @default.
- W2154382135 cites W1991149146 @default.
- W2154382135 cites W1992591459 @default.
- W2154382135 cites W1992637173 @default.
- W2154382135 cites W1994125097 @default.
- W2154382135 cites W1995017064 @default.
- W2154382135 cites W1995545250 @default.
- W2154382135 cites W2001641653 @default.
- W2154382135 cites W2002932837 @default.
- W2154382135 cites W2004254961 @default.
- W2154382135 cites W2005641593 @default.
- W2154382135 cites W2008708467 @default.
- W2154382135 cites W2010330695 @default.
- W2154382135 cites W2012072946 @default.
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- W2154382135 cites W2030517878 @default.
- W2154382135 cites W2032646708 @default.
- W2154382135 cites W2033093530 @default.
- W2154382135 cites W2035644151 @default.
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- W2154382135 doi "https://doi.org/10.1002/pro.2054" @default.
- W2154382135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3403466" @default.
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