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• W2154382502 endingPage "633" @default.
• W2154382502 startingPage "625" @default.
• W2154382502 abstract "Objectives The purpose of this study was to determine whether contrast-enhanced sonography can be used to differentiate histopathologic grades of hepatocellular carcinoma. Methods This study included 54 patients with hepatocellular carcinomas. All patients underwent fundamental and contrast-enhanced sonographic examinations. Auto-tracking contrast quantification software was used to determine the contrast arrival time, time to peak, peak intensity, contrast-enhanced time, wash-out time, enhancement slope, and clearance slope of the lesions. All lesions were confirmed by surgery. The hepatocellular carcinoma lesions were divided into 2 groups according to the World Health Organization grading system: group 1 (well-differentiated hepatocellular carcinomas) and group 2 (moderately to poorly differentiated carcinomas). The enhancement parameters between the groups were compared using a Student t test. Results Fourteen of 20 well-differentiated lesions showed a “fast-in, slow-out” enhancement pattern, whereas 6 showed a “fast-in, fast-out” pattern. Thirty-three of 34 moderately to poorly differentiated lesions showed a fast-in, fast-out pattern, whereas only 1 showed a fast-in, slow-out pattern. The differences in the time to peak, contrast-enhanced time, wash-out time, enhancement slope, and clearance slope between the groups were statistically significant (P < .05), whereas the differences in the arrival time and peak intensity were not significant (P > .05). Conclusions The contrast patterns of well-differentiated and moderately to poorly differentiated hepatocellular carcinomas were quite different on contrast-enhanced sonography. The time to peak, contrast-enhanced time, and wash-out time of the well-differentiated hepatocellular carcinomas were longer than those of the moderately to poorly differentiated carcinomas, whereas the enhancement slope and clearance slope of the well-differentiated lesions were lower those that of the moderately to poorly differentiated lesions." @default.
• W2154382502 created "2016-06-24" @default.
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• W2154382502 date "2011-05-01" @default.
• W2154382502 modified "2023-10-07" @default.
• W2154382502 title "Evaluation of Hepatocellular Carcinoma by Contrast-Enhanced Sonography" @default.
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• W2154382502 doi "https://doi.org/10.7863/jum.2011.30.5.625" @default.
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