FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154408022> ?p ?o ?g. }

• W2154408022 endingPage "163" @default.
• W2154408022 startingPage "155" @default.
• W2154408022 abstract "With the introduction of positron-emitting radionuclides with half-lifes in days, such as 89Zr and 124I, radioimmunoscintigraphy (RIS) with positron-emitter-labeled monoclonal antibodies (moAbs) becomes feasible. RIS, using positron emission tomography (immuno-PET), combines the specific localization of an antibody with the high resolution of a PET camera. In the present study, scintigraphic tumor imaging using chimeric moAb G250 labeled with 89Zr (immuno-PET) or 111In (RIS), and [18F]FDG-(PET) was explored in rats with s.c. renal cell carcinoma (RCC) tumors.Nude rats (6-8 rats per group) with s.c. SK-RC-52 tumors were i.v. injected with 4 MBq 111InDTPA-cG250, 20 MBq 89Zr-Df-cG250 or 4 MBq [18F]FDG. Planar 111In-DTPA-cG250 images were obtained 5 minutes, and 24, 48, and 72 hours postinjection (p.i.). 3D PET imaging was performed 5 minutes, and 24, 48, and 72 hours after a 89Zr-Df-cG250 injection and 1 hour after a [18F]FDG injection using a Siemens ECAT EXACT PET camera. Rats were killed after the last imaging session, and the uptake of the radiolabel in the dissected tissues was determined.Both radiolabeled antibody preparations were stable during 4 days of incubation in serum at 37 degrees C, and the immunoreactivity was preserved. Two (2) days after injection, s.c. tumors (100 mg) were clearly visualized, both with 89Zr-Df-cG250 and 111In-DTPA-cG250. Tumors were not visualized with [18F]FDG (uptake in tumor of 0.5 +/- 0.1 %ID/g, 1 hour p.i.). The biodistribution experiments showed an identical uptake in the tumor for both 89Zr-Df-cG250 and 111In-DTPA-cG250 at 3 days p.i. (5.0 +/- 2.4 and 4.9 +/- 2.9 %ID/g, respectively). Blood levels at 3 days p.i. were also identical (1.4 +/- 0.4 versus 1.7 +/- 0.7 %ID/g), and no significant differences were found in the biodistribution of normal tissues between the two radiolabeled cG250 preparations.The cG250 antibody can be stably labeled with the positron-emitter 89Zr, while preserving the immunoreactivity of the moAb. In this rat model, the in vivo biodistribution of 89Zr-Df-cG250 was identical to that of 111In-DTPA-cG250. Immuno-PET of RCC is feasible with 89Zr-cG250, and relatively small tumors could be visualized, even without a dedicated PET camera for small animals." @default.
• W2154408022 created "2016-06-24" @default.
• W2154408022 creator A5000396669 @default.
• W2154408022 creator A5003550390 @default.
• W2154408022 creator A5011168863 @default.
• W2154408022 creator A5012764804 @default.
• W2154408022 creator A5018481009 @default.
• W2154408022 creator A5038420155 @default.
• W2154408022 creator A5042792515 @default.
• W2154408022 creator A5056620057 @default.
• W2154408022 creator A5062365111 @default.
• W2154408022 creator A5072881153 @default.
• W2154408022 date "2004-04-01" @default.
• W2154408022 modified "2023-09-30" @default.
• W2154408022 title "PET Radioimmunoscintigraphy of Renal Cell Cancer Using ⁸⁹Zr-Labeled cG250 Monoclonal Antibody in Nude Rats" @default.
• W2154408022 cites W1973826816 @default.
• W2154408022 cites W1976143884 @default.
• W2154408022 cites W1984947150 @default.
• W2154408022 cites W1996400431 @default.
• W2154408022 cites W2014119008 @default.
• W2154408022 cites W2022593681 @default.
• W2154408022 cites W2026411584 @default.
• W2154408022 cites W2058426435 @default.
• W2154408022 cites W2085913297 @default.
• W2154408022 cites W2095637914 @default.
• W2154408022 cites W2139367713 @default.
• W2154408022 cites W2150111624 @default.
• W2154408022 cites W2168966763 @default.
• W2154408022 cites W2174939397 @default.
• W2154408022 cites W2322993109 @default.
• W2154408022 cites W4229906152 @default.
• W2154408022 doi "https://doi.org/10.1089/108497804323071922" @default.
• W2154408022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15186595" @default.
• W2154408022 hasPublicationYear "2004" @default.
• W2154408022 type Work @default.
• W2154408022 sameAs 2154408022 @default.
• W2154408022 citedByCount "66" @default.
• W2154408022 countsByYear W21544080222012 @default.
• W2154408022 countsByYear W21544080222013 @default.
• W2154408022 countsByYear W21544080222014 @default.
• W2154408022 countsByYear W21544080222016 @default.
• W2154408022 countsByYear W21544080222017 @default.
• W2154408022 countsByYear W21544080222019 @default.
• W2154408022 countsByYear W21544080222020 @default.
• W2154408022 countsByYear W21544080222021 @default.
• W2154408022 countsByYear W21544080222022 @default.
• W2154408022 countsByYear W21544080222023 @default.
• W2154408022 crossrefType "journal-article" @default.
• W2154408022 hasAuthorship W2154408022A5000396669 @default.
• W2154408022 hasAuthorship W2154408022A5003550390 @default.
• W2154408022 hasAuthorship W2154408022A5011168863 @default.
• W2154408022 hasAuthorship W2154408022A5012764804 @default.
• W2154408022 hasAuthorship W2154408022A5018481009 @default.
• W2154408022 hasAuthorship W2154408022A5038420155 @default.
• W2154408022 hasAuthorship W2154408022A5042792515 @default.
• W2154408022 hasAuthorship W2154408022A5056620057 @default.
• W2154408022 hasAuthorship W2154408022A5062365111 @default.
• W2154408022 hasAuthorship W2154408022A5072881153 @default.
• W2154408022 hasBestOaLocation W21544080222 @default.
• W2154408022 hasConcept C142724271 @default.
• W2154408022 hasConcept C150903083 @default.
• W2154408022 hasConcept C159654299 @default.
• W2154408022 hasConcept C203014093 @default.
• W2154408022 hasConcept C207001950 @default.
• W2154408022 hasConcept C2775842073 @default.
• W2154408022 hasConcept C2776146153 @default.
• W2154408022 hasConcept C2777472916 @default.
• W2154408022 hasConcept C2777807558 @default.
• W2154408022 hasConcept C2781278892 @default.
• W2154408022 hasConcept C2989005 @default.
• W2154408022 hasConcept C542903549 @default.
• W2154408022 hasConcept C71924100 @default.
• W2154408022 hasConcept C86803240 @default.
• W2154408022 hasConceptScore W2154408022C142724271 @default.
• W2154408022 hasConceptScore W2154408022C150903083 @default.
• W2154408022 hasConceptScore W2154408022C159654299 @default.
• W2154408022 hasConceptScore W2154408022C203014093 @default.
• W2154408022 hasConceptScore W2154408022C207001950 @default.
• W2154408022 hasConceptScore W2154408022C2775842073 @default.
• W2154408022 hasConceptScore W2154408022C2776146153 @default.
• W2154408022 hasConceptScore W2154408022C2777472916 @default.
• W2154408022 hasConceptScore W2154408022C2777807558 @default.
• W2154408022 hasConceptScore W2154408022C2781278892 @default.
• W2154408022 hasConceptScore W2154408022C2989005 @default.
• W2154408022 hasConceptScore W2154408022C542903549 @default.
• W2154408022 hasConceptScore W2154408022C71924100 @default.
• W2154408022 hasConceptScore W2154408022C86803240 @default.
• W2154408022 hasIssue "2" @default.
• W2154408022 hasLocation W21544080221 @default.
• W2154408022 hasLocation W21544080222 @default.
• W2154408022 hasLocation W21544080223 @default.
• W2154408022 hasOpenAccess W2154408022 @default.
• W2154408022 hasPrimaryLocation W21544080221 @default.
• W2154408022 hasRelatedWork W1858303686 @default.
• W2154408022 hasRelatedWork W1971628265 @default.
• W2154408022 hasRelatedWork W1973774944 @default.
• W2154408022 hasRelatedWork W1985628011 @default.
• W2154408022 hasRelatedWork W2080917628 @default.

• next