FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154420218> ?p ?o ?g. }

• W2154420218 endingPage "159" @default.
• W2154420218 startingPage "158" @default.
• W2154420218 abstract "isotretretinoin (positive de-challenge) and re-emerged whenever the drug was re-administered (positive re-challenges); the remaining cases scored 3 on the Naranjo scale (“possible” ADR). In all four cases, however, the temporal relationship (1- or 2-month interval) between isotretinoin administration and the appearance of psychiatric symptoms shows that the drug was the most probable triggering factor.The multiformity of isotretinoin-induced psy-chiatric adverse events is only partly accounted for by the multiplicity of the drug’s effects on various neurotransmitter systems and brain structures (Goodman 1998; Bremner and McCaffery 2008). In this case series, we speculate a potential role for the various types of genetic vulnerability of the exposed individuals in the emergence of diverse psychiatric symptoms, an effect that has scarcely been investi-gated to date (Barak et al. 2005). For example, in cases #1 and #3 each of which had a family history loading for both psychosis and affective disorder, isotretinoin induced a mixed clinical syndrome with both psychotic and depressive features (“schizo-affective disorder”, “psychotic depression”). In cases #2 and #4 which had a loading for affective disor-der or psychosis, the induced syndrome was (non-psychotic) “major depression” or “schizophrenia”, respectively. We suggest that isotretinoin-induced psychiatric symptoms might be generated through a gene–environment interaction, with isotretinoin as an undifferentiated environmental stressor and its effects being modulated by the various types of genetic vulnerability of the exposed individuals.In conclusion, cases reported add to a few pre-vious similar reports of isotretinoin-induced psychi-atric manifestations in individuals with a positive To the Editors,Isotretinoin, a synthetic retinoid that is used against severe, recalcitrant nodulocystic acne, has been asso-ciated in several case-series and some retrospective and uncontrolled studies with various psychiatric side-effects (depression, violent behaviour, suicidality and psychotic symptoms) (Ng et al. 2001; Hull and d’Arcy 2003; Kontaxakis et al. 2009). Depressive symptoms are most often reported at 1 month after isotretinoin initiation at an estimated incidence of 1–11% (Bremner and McCaffery 2008). The first controlled study to find a statistically significant asso-ciation between isotretinoin and depression (relative risk 2.68) was recently published (Azoulay et al. 2008). However, the causal link between isotretinoin use and psychiatric adverse events remains controver-sial mainly due to poor quality of existing evidence (Strahan and Raimer 2006). We present four patients consecutively hospital-ized in our department during 2008 whose psychi-atric symptoms (depression, suicidality, psychotic symptoms) were possibly induced by isotretinoin administration. All patients had a positive family his-tory for psychiatric disorders. In Table I, clinicode-mographic characteristics of the four patients are presented. Determining the likelihood of whether a symptom is actually an adverse drug reaction (ADR) is often quite complicated (Naranjo et al. 1981; Mann et al. 2008). It is obvious that an association of isotretinoin use with psychopathology is not equally demonstrated by all cases presented. The strongest association can be established for case #3 (Naranjo score 5: “probable” ADR), whose psychi-atric symptoms remitted upon discontinuation of" @default.
• W2154420218 created "2016-06-24" @default.
• W2154420218 creator A5016846911 @default.
• W2154420218 creator A5036767968 @default.
• W2154420218 creator A5087472890 @default.
• W2154420218 creator A5024639606 @default.
• W2154420218 date "2010-01-01" @default.
• W2154420218 modified "2023-10-09" @default.
• W2154420218 title "Genetic vulnerability and isotretinoin-induced psychiatric adverse events" @default.
• W2154420218 cites W1986486574 @default.
• W2154420218 cites W2005922571 @default.
• W2154420218 cites W2030391125 @default.
• W2154420218 cites W2032840761 @default.
• W2154420218 cites W2061173449 @default.
• W2154420218 cites W2065486424 @default.
• W2154420218 cites W2066887339 @default.
• W2154420218 cites W2067978628 @default.
• W2154420218 cites W2072507718 @default.
• W2154420218 cites W2114987540 @default.
• W2154420218 doi "https://doi.org/10.3109/15622970903449853" @default.
• W2154420218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20109108" @default.
• W2154420218 hasPublicationYear "2010" @default.
• W2154420218 type Work @default.
• W2154420218 sameAs 2154420218 @default.
• W2154420218 citedByCount "7" @default.
• W2154420218 countsByYear W21544202182012 @default.
• W2154420218 countsByYear W21544202182017 @default.
• W2154420218 countsByYear W21544202182019 @default.
• W2154420218 countsByYear W21544202182021 @default.
• W2154420218 crossrefType "journal-article" @default.
• W2154420218 hasAuthorship W2154420218A5016846911 @default.
• W2154420218 hasAuthorship W2154420218A5024639606 @default.
• W2154420218 hasAuthorship W2154420218A5036767968 @default.
• W2154420218 hasAuthorship W2154420218A5087472890 @default.
• W2154420218 hasConcept C118552586 @default.
• W2154420218 hasConcept C15744967 @default.
• W2154420218 hasConcept C16005928 @default.
• W2154420218 hasConcept C197934379 @default.
• W2154420218 hasConcept C2776285725 @default.
• W2154420218 hasConcept C2777673923 @default.
• W2154420218 hasConcept C38652104 @default.
• W2154420218 hasConcept C41008148 @default.
• W2154420218 hasConcept C71924100 @default.
• W2154420218 hasConcept C95713431 @default.
• W2154420218 hasConcept C98274493 @default.
• W2154420218 hasConceptScore W2154420218C118552586 @default.
• W2154420218 hasConceptScore W2154420218C15744967 @default.
• W2154420218 hasConceptScore W2154420218C16005928 @default.
• W2154420218 hasConceptScore W2154420218C197934379 @default.
• W2154420218 hasConceptScore W2154420218C2776285725 @default.
• W2154420218 hasConceptScore W2154420218C2777673923 @default.
• W2154420218 hasConceptScore W2154420218C38652104 @default.
• W2154420218 hasConceptScore W2154420218C41008148 @default.
• W2154420218 hasConceptScore W2154420218C71924100 @default.
• W2154420218 hasConceptScore W2154420218C95713431 @default.
• W2154420218 hasConceptScore W2154420218C98274493 @default.
• W2154420218 hasIssue "2" @default.
• W2154420218 hasLocation W21544202181 @default.
• W2154420218 hasLocation W21544202182 @default.
• W2154420218 hasOpenAccess W2154420218 @default.
• W2154420218 hasPrimaryLocation W21544202181 @default.
• W2154420218 hasRelatedWork W1856453150 @default.
• W2154420218 hasRelatedWork W2054908596 @default.
• W2154420218 hasRelatedWork W2109592716 @default.
• W2154420218 hasRelatedWork W2111132207 @default.
• W2154420218 hasRelatedWork W2224239028 @default.
• W2154420218 hasRelatedWork W2609871934 @default.
• W2154420218 hasRelatedWork W2748952813 @default.
• W2154420218 hasRelatedWork W2899084033 @default.
• W2154420218 hasRelatedWork W3193000512 @default.
• W2154420218 hasRelatedWork W4281664392 @default.
• W2154420218 hasVolume "11" @default.
• W2154420218 isParatext "false" @default.
• W2154420218 isRetracted "false" @default.
• W2154420218 magId "2154420218" @default.
• W2154420218 workType "article" @default.