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- W2154438166 abstract "Introduction: The metabolic syndrome characterized by central obesity, insulin and lipid dysregulation, and hypertension,is a precursor state for atherosclerotic process and, in consequence, cardiovascular disease. Decline of both testicularand adrenal function with aging causes a decrease in androgen concentration in men. It has been postulated that low levelsof total testosterone and dehydroepiandrosterone sulfate (DHEA-S) are associated with unfavorable levels of several strongcardiovascular disease risk factors, such as lipids and blood pleasure, which are components of the metabolic syndrome,and insulin levels. Both testosterone and DHEA-S deficiency are risk factors of obesity and insulin resistance, but it is notclear, whether this possible influence is independent. The aim of this study was to determined whether lower androgens(testosterone and DHEA-S) levels are associated with the development of metabolic syndrome in non-obese elderly men aswell as analysis, whether these sex hormones influents on measured parameters separately. Material and methods: Together 85 men age from 60 to 70 years (mean 66.3 ± 1.5 years; mean ± SEM) were analyzed.Testosterone levels 2 were including criteria. Patients weredivided into three groups: 52 with testosterone deficiency (L-T), 32 with DHEA deficiency (L-DHEA-S) and 67 with deficiencyof both sex hormones (L-T/DHEA-S). The influence of sex hormones deficiency in these groups on blood pressure,lipids, visceral obesity and fasting glucose were measured (according to metabolic syndrome definition NCEP III/IDF). Results: Testosterone levels in L-T, L-DHEA and L-T/DHEA-S groups were respectively 3.19 ± 0.23 ng/ml, 4.89 ± 0.45 ng/mland 3.25 ± 0.34 g/ml (p vs. L-T andL-DHEA-S groups). Mean triglycerides concentration in L-T/DHEA-S group was significantly higher than in L-T andL-DHEA-S groups (respectively: 188.2 ± 13.3 mg/dl, 161.7 ± 14.7 mg/dl and 152.2 ± 12.8 mg/dl (mean ± SD; p vs. L-T and L-DHEA-S groups). Analysis of prevalence of risk factors showed, that in L-T/DHEA-S group they were morefrequent than in other groups. The most significant percentage difference was observed for triglycerides: concentration≥ 150 mg/dl was measured in 31% men in L-T group, 28% men in L-DHEA-S group and 42% men in L-T/DHEA-S group.According metabolic syndrome definition NCEP III/IDF prevalence of this syndrome was: 71% patients in L-T/DHEA-Sgroup, 67% patients in L-T group and 64% patients in L-DHEA-S group. Conclusions: The DHEA-S and testosterone deficiency was a significant and independent risk factor of the metabolic syndromein non-obese elderly men. It seems, that triglycerides concentration and waist circumference are more sensitive thenothers parameters to reflect the influence of sex hormones deficiency on risk of the metabolic syndrome in elderly men." @default.
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- W2154438166 date "2007-11-01" @default.
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- W2154438166 title "[The relationship between androgens concentrations (testosterone and dehydroepiandrosterone sulfate) and metabolic syndrome in non-obese elderly men]." @default.
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