FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154443994> ?p ?o ?g. }

• W2154443994 endingPage "4581" @default.
• W2154443994 startingPage "4571" @default.
• W2154443994 abstract "Peroxynitrite is produced during inflammation and combines rapidly with carbon dioxide to yield the unstable nitrosoperoxycarbonate, which decomposes (in part) to CO(3) (.-) and (.)NO(2) radicals. The CO(3) (.-) radicals oxidize guanine bases in DNA through a one-electron transfer reaction process that ultimately results in the formation of stable guanine oxidation products. Here we have explored these mechanisms, starting with a spectroscopic study of the kinetics of electron transfer from 20-22mer double-stranded oligonucleotides to CO(3) (.-) radicals, together with the effects of base sequence on the formation of the end-products in runs of one, two, or three contiguous guanines. The distributions of these alkali-labile lesions were determined by gel electrophoresis methods. The cascade of events was initiated through the use of 308 nm XeCl excimer laser pulses to generate CO(3) (.-) radicals by an established method based on the photodissociation of persulfate to sulfate radicals and the oxidation of bicarbonate. Although the Saito model (Saito et al., J. Am. Chem. Soc. 1995, 117, 6406-6407) predicts relative ease of one-electron oxidations in DNA, following the trend 5'-GGG > 5'-GG > 5'-G, we found that the rate constants for CO(3) (.-)-mediated oxidation of guanines in these sequence contexts (k(5)) showed only small variation within a narrow range [(1.5-3.0)x10(7) M(-1) s(-1)]. In contrast, the distributions of the end-products are dependent on the base sequence context and are higher at the 5'-G in 5'-GG sequences and at the first two 5'-guanines in the 5'-GGG sequences. These effects are attributed to a combination of initial hole distributions among the contiguous guanines and the subsequent differences in chemical reaction yields at each guanine. The lack of dependence of k(5) on sequence context indicates that the one-electron oxidation of guanine in DNA by CO(3) (.-) radicals occurs by an inner-sphere mechanism." @default.
• W2154443994 created "2016-06-24" @default.
• W2154443994 creator A5000799004 @default.
• W2154443994 creator A5004499334 @default.
• W2154443994 creator A5018460703 @default.
• W2154443994 creator A5022300231 @default.
• W2154443994 creator A5050729141 @default.
• W2154443994 creator A5068343349 @default.
• W2154443994 creator A5081031918 @default.
• W2154443994 date "2007-05-25" @default.
• W2154443994 modified "2023-09-27" @default.
• W2154443994 title "Mechanisms of Oxidation of Guanine in DNA by Carbonate Radical Anion, a Decomposition Product of Nitrosoperoxycarbonate" @default.
• W2154443994 cites W1926950498 @default.
• W2154443994 cites W1963712961 @default.
• W2154443994 cites W1965037168 @default.
• W2154443994 cites W1967955672 @default.
• W2154443994 cites W1969408680 @default.
• W2154443994 cites W1975532341 @default.
• W2154443994 cites W1977184994 @default.
• W2154443994 cites W1979254256 @default.
• W2154443994 cites W1981560246 @default.
• W2154443994 cites W1981721049 @default.
• W2154443994 cites W1990842653 @default.
• W2154443994 cites W1990994084 @default.
• W2154443994 cites W1991670944 @default.
• W2154443994 cites W2000774559 @default.
• W2154443994 cites W2004191494 @default.
• W2154443994 cites W2004949340 @default.
• W2154443994 cites W2006704568 @default.
• W2154443994 cites W2008680254 @default.
• W2154443994 cites W2009646148 @default.
• W2154443994 cites W2012232453 @default.
• W2154443994 cites W2021914341 @default.
• W2154443994 cites W2025842644 @default.
• W2154443994 cites W2028877298 @default.
• W2154443994 cites W2031904472 @default.
• W2154443994 cites W2034916420 @default.
• W2154443994 cites W2037647371 @default.
• W2154443994 cites W2037937229 @default.
• W2154443994 cites W2040591698 @default.
• W2154443994 cites W2040843368 @default.
• W2154443994 cites W2041628963 @default.
• W2154443994 cites W2046497217 @default.
• W2154443994 cites W2048270768 @default.
• W2154443994 cites W2049262074 @default.
• W2154443994 cites W2052350481 @default.
• W2154443994 cites W2054170411 @default.
• W2154443994 cites W2058137293 @default.
• W2154443994 cites W2060043270 @default.
• W2154443994 cites W2060912121 @default.
• W2154443994 cites W2061051932 @default.
• W2154443994 cites W2061224795 @default.
• W2154443994 cites W2061419115 @default.
• W2154443994 cites W2064344250 @default.
• W2154443994 cites W2065582624 @default.
• W2154443994 cites W2067577602 @default.
• W2154443994 cites W2069779383 @default.
• W2154443994 cites W2072400609 @default.
• W2154443994 cites W2076608851 @default.
• W2154443994 cites W2077164511 @default.
• W2154443994 cites W2083806934 @default.
• W2154443994 cites W2085134918 @default.
• W2154443994 cites W2088111404 @default.
• W2154443994 cites W2088738503 @default.
• W2154443994 cites W2090685881 @default.
• W2154443994 cites W2091954160 @default.
• W2154443994 cites W2093041725 @default.
• W2154443994 cites W2093674811 @default.
• W2154443994 cites W2093967217 @default.
• W2154443994 cites W2094745968 @default.
• W2154443994 cites W2107601759 @default.
• W2154443994 cites W2109893157 @default.
• W2154443994 cites W2113691971 @default.
• W2154443994 cites W2116554142 @default.
• W2154443994 cites W2124809332 @default.
• W2154443994 cites W2125645992 @default.
• W2154443994 cites W2140365442 @default.
• W2154443994 cites W2143156811 @default.
• W2154443994 cites W2159454395 @default.
• W2154443994 cites W2165337540 @default.
• W2154443994 cites W2168044784 @default.
• W2154443994 cites W2168498213 @default.
• W2154443994 cites W2171815233 @default.
• W2154443994 cites W314323317 @default.
• W2154443994 cites W4210607883 @default.
• W2154443994 cites W4234012592 @default.
• W2154443994 doi "https://doi.org/10.1002/chem.200601434" @default.
• W2154443994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17335089" @default.
• W2154443994 hasPublicationYear "2007" @default.
• W2154443994 type Work @default.
• W2154443994 sameAs 2154443994 @default.
• W2154443994 citedByCount "55" @default.
• W2154443994 countsByYear W21544439942012 @default.
• W2154443994 countsByYear W21544439942013 @default.
• W2154443994 countsByYear W21544439942014 @default.
• W2154443994 countsByYear W21544439942016 @default.
• W2154443994 countsByYear W21544439942017 @default.
• W2154443994 countsByYear W21544439942018 @default.

• next