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- W2154455853 abstract "Accumulating evidence suggested that epigenetic changes such as promoter-specific DNA hypermethylation and histone deacetylation cause tumor suppressor gene silencing and contribute to malignant transformation. Treatment of cancer cells with HDAC inhibitors can reactivate the expression of silenced genes, block the cell cycle, and induce cell apoptosis. In vitro experiments in cancer cell cultures and in vivo studies using mouse xynograft model have shown that HDAC inhibitors deliver potent anti-cancer effects. Clinical trials have led to approval of SAHA (Vorinostat) for treatment of lymphoma. Endometrial cancer (EC) is the most frequent malignancy in women’s reproductive tract. EC is known for extensive epigenetic alterations, including overexpression of HDAC and DNMT enzymes, and the frequent epigenetic silencing of DNA repair genes such as MLH1, tumor suppressor genes PTEN, and progesterone receptor, which suggests a potentially high sensitivity of this type of cancer to HDAC inhibitors. Indeed, studies from many laboratories using various models have shown that HDAC inhibitors are promising chemotherapy reagents for endometrial cancers. This review summarizes the results from these studies, with an emphasis to provide an update on the new findings from new drugs. Background information on HDAC expression in EC, and features of HDAC inhibitors are presented based on their relevance to our focused topic. The combined application of HDAC inhibitors with radiation therapy and other conventional therapeutic reagents are also discussed. Keywords: Histone deacetylases, endometrial cancers, Inhibitors, therapeutic target." @default.
- W2154455853 created "2016-06-24" @default.
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- W2154455853 date "2014-04-01" @default.
- W2154455853 modified "2023-10-05" @default.
- W2154455853 title "HDAC as a Therapeutic Target for Treatment of Endometrial Cancers" @default.
- W2154455853 cites W1481999472 @default.
- W2154455853 cites W1514623505 @default.
- W2154455853 cites W1534598827 @default.
- W2154455853 cites W1574682683 @default.
- W2154455853 cites W1812576394 @default.
- W2154455853 cites W1827980340 @default.
- W2154455853 cites W1835871681 @default.
- W2154455853 cites W1843609228 @default.
- W2154455853 cites W1935102817 @default.
- W2154455853 cites W1966440259 @default.
- W2154455853 cites W1967018540 @default.
- W2154455853 cites W1968356004 @default.
- W2154455853 cites W1976634184 @default.
- W2154455853 cites W1982619775 @default.
- W2154455853 cites W1982886249 @default.
- W2154455853 cites W1990612902 @default.
- W2154455853 cites W1993943690 @default.
- W2154455853 cites W1998475911 @default.
- W2154455853 cites W2001335885 @default.
- W2154455853 cites W2006866162 @default.
- W2154455853 cites W2015009560 @default.
- W2154455853 cites W2017204495 @default.
- W2154455853 cites W2022907438 @default.
- W2154455853 cites W2023437193 @default.
- W2154455853 cites W2025412384 @default.
- W2154455853 cites W2026033409 @default.
- W2154455853 cites W2026969834 @default.
- W2154455853 cites W2030170923 @default.
- W2154455853 cites W2031694936 @default.
- W2154455853 cites W2031954417 @default.
- W2154455853 cites W2032025341 @default.
- W2154455853 cites W2034805205 @default.
- W2154455853 cites W2037108573 @default.
- W2154455853 cites W2041057224 @default.
- W2154455853 cites W2043335790 @default.
- W2154455853 cites W2049799323 @default.
- W2154455853 cites W2051026285 @default.
- W2154455853 cites W2051152566 @default.
- W2154455853 cites W2052181006 @default.
- W2154455853 cites W2054576779 @default.
- W2154455853 cites W2056656235 @default.
- W2154455853 cites W2057916687 @default.
- W2154455853 cites W2059662724 @default.
- W2154455853 cites W2060300649 @default.
- W2154455853 cites W2060982818 @default.
- W2154455853 cites W2061352751 @default.
- W2154455853 cites W2064602574 @default.
- W2154455853 cites W2070089404 @default.
- W2154455853 cites W2071513872 @default.
- W2154455853 cites W2072133690 @default.
- W2154455853 cites W2072375912 @default.
- W2154455853 cites W2072434608 @default.
- W2154455853 cites W2073286776 @default.
- W2154455853 cites W2079029980 @default.
- W2154455853 cites W2080866562 @default.
- W2154455853 cites W2081036615 @default.
- W2154455853 cites W2082739830 @default.
- W2154455853 cites W2086979653 @default.
- W2154455853 cites W2089417788 @default.
- W2154455853 cites W2090062530 @default.
- W2154455853 cites W2090284404 @default.
- W2154455853 cites W2093191347 @default.
- W2154455853 cites W2094464106 @default.
- W2154455853 cites W2094744378 @default.
- W2154455853 cites W2098249941 @default.
- W2154455853 cites W2099803844 @default.
- W2154455853 cites W2101092227 @default.
- W2154455853 cites W2101979121 @default.
- W2154455853 cites W2102458112 @default.
- W2154455853 cites W2102934487 @default.
- W2154455853 cites W2104805076 @default.
- W2154455853 cites W2105208768 @default.
- W2154455853 cites W2105960770 @default.
- W2154455853 cites W2106357158 @default.
- W2154455853 cites W2107270084 @default.
- W2154455853 cites W2107733280 @default.