FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154455877> ?p ?o ?g. }

• W2154455877 endingPage "30" @default.
• W2154455877 startingPage "4724" @default.
• W2154455877 abstract "Spleen tyrosine kinase (Syk) is a candidate tumor (metastasis) suppressor that is highly expressed in mammary epithelial cells. Loss of Syk expression through promoter hypermethylation is associated with increased invasiveness in a subset of breast cancer. Here, we show that in addition to full-length Syk [Syk(L)], an alternatively spliced variant, Syk(S), is frequently expressed in breast cancer cells. Syk(S) is identical to Syk(L), except that it lacks 23 amino acid residues (deletion) within the interdomain B (IDB) of Syk. We also show that the aberrant expression of Syk(S) occurs frequently in primary breast tumors but never in matched normal mammary tissues, suggesting a contribution of Syk(S) to mammary tumor progression. Expression of Syk(L) suppressed breast cancer cell invasiveness. In contrast, Syk(S) expression did not affect the cell invasion potential. This differential phenotypic response is accompanied by their different subcellular localization. Immunocytochemical studies and nuclear and cytoplasmic fractionation experiments indicated that Syk(L) could enter the nucleus, whereas Syk(S) was located exclusively in the cytoplasm. Five basic residues in deletion were found to be critical in determining Syk(L) nuclear transport and invasion suppression activity; mutations completely excluded Syk(L) from the nucleus and blocked Syk(L)-inducible invasion suppression. Moreover, IDB acted as an autonomous nuclear localization signal to facilitate nuclear transport of a heterologous protein. Thus, the IDB of Syk(L) contains a nuclear localization signal that is responsible for Syk(L) nuclear translocation. The correlation of the nuclear localization and invasion suppression function of Syk(L) indicated that nuclear Syk possesses biological activities associated with tumor suppression in mammary epithelial cells." @default.
• W2154455877 created "2016-06-24" @default.
• W2154455877 creator A5001315712 @default.
• W2154455877 creator A5016238883 @default.
• W2154455877 creator A5041098535 @default.
• W2154455877 creator A5053371461 @default.
• W2154455877 creator A5064088146 @default.
• W2154455877 creator A5065538168 @default.
• W2154455877 creator A5066474172 @default.
• W2154455877 creator A5073216396 @default.
• W2154455877 date "2003-08-01" @default.
• W2154455877 modified "2023-09-29" @default.
• W2154455877 title "Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer." @default.
• W2154455877 cites W1540271729 @default.
• W2154455877 cites W1543981199 @default.
• W2154455877 cites W1547692523 @default.
• W2154455877 cites W1573034858 @default.
• W2154455877 cites W1608689696 @default.
• W2154455877 cites W1639366885 @default.
• W2154455877 cites W1804861156 @default.
• W2154455877 cites W1967141802 @default.
• W2154455877 cites W1968260614 @default.
• W2154455877 cites W1970663543 @default.
• W2154455877 cites W1979617068 @default.
• W2154455877 cites W1983960385 @default.
• W2154455877 cites W1988222207 @default.
• W2154455877 cites W1994465394 @default.
• W2154455877 cites W2003319634 @default.
• W2154455877 cites W2006038022 @default.
• W2154455877 cites W2008072603 @default.
• W2154455877 cites W2009082398 @default.
• W2154455877 cites W2012537699 @default.
• W2154455877 cites W2018542248 @default.
• W2154455877 cites W2019893381 @default.
• W2154455877 cites W2022432463 @default.
• W2154455877 cites W2041726757 @default.
• W2154455877 cites W2042154282 @default.
• W2154455877 cites W2044336492 @default.
• W2154455877 cites W2047385558 @default.
• W2154455877 cites W2053972865 @default.
• W2154455877 cites W2054823635 @default.
• W2154455877 cites W2060088582 @default.
• W2154455877 cites W2064540749 @default.
• W2154455877 cites W2069232697 @default.
• W2154455877 cites W2086725260 @default.
• W2154455877 cites W2087947799 @default.
• W2154455877 cites W2089783130 @default.
• W2154455877 cites W2090863009 @default.
• W2154455877 cites W2132795628 @default.
• W2154455877 cites W2142739945 @default.
• W2154455877 cites W2150265245 @default.
• W2154455877 cites W2152251826 @default.
• W2154455877 cites W2157383269 @default.
• W2154455877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12907655" @default.
• W2154455877 hasPublicationYear "2003" @default.
• W2154455877 type Work @default.
• W2154455877 sameAs 2154455877 @default.
• W2154455877 citedByCount "51" @default.
• W2154455877 countsByYear W21544558772012 @default.
• W2154455877 countsByYear W21544558772013 @default.
• W2154455877 countsByYear W21544558772015 @default.
• W2154455877 countsByYear W21544558772016 @default.
• W2154455877 countsByYear W21544558772017 @default.
• W2154455877 countsByYear W21544558772018 @default.
• W2154455877 countsByYear W21544558772019 @default.
• W2154455877 countsByYear W21544558772021 @default.
• W2154455877 countsByYear W21544558772022 @default.
• W2154455877 countsByYear W21544558772023 @default.
• W2154455877 crossrefType "journal-article" @default.
• W2154455877 hasAuthorship W2154455877A5001315712 @default.
• W2154455877 hasAuthorship W2154455877A5016238883 @default.
• W2154455877 hasAuthorship W2154455877A5041098535 @default.
• W2154455877 hasAuthorship W2154455877A5053371461 @default.
• W2154455877 hasAuthorship W2154455877A5064088146 @default.
• W2154455877 hasAuthorship W2154455877A5065538168 @default.
• W2154455877 hasAuthorship W2154455877A5066474172 @default.
• W2154455877 hasAuthorship W2154455877A5073216396 @default.
• W2154455877 hasConcept C190062978 @default.
• W2154455877 hasConcept C35174551 @default.
• W2154455877 hasConcept C42362537 @default.
• W2154455877 hasConcept C49805395 @default.
• W2154455877 hasConcept C502942594 @default.
• W2154455877 hasConcept C62478195 @default.
• W2154455877 hasConcept C86803240 @default.
• W2154455877 hasConcept C95444343 @default.
• W2154455877 hasConceptScore W2154455877C190062978 @default.
• W2154455877 hasConceptScore W2154455877C35174551 @default.
• W2154455877 hasConceptScore W2154455877C42362537 @default.
• W2154455877 hasConceptScore W2154455877C49805395 @default.
• W2154455877 hasConceptScore W2154455877C502942594 @default.
• W2154455877 hasConceptScore W2154455877C62478195 @default.
• W2154455877 hasConceptScore W2154455877C86803240 @default.
• W2154455877 hasConceptScore W2154455877C95444343 @default.
• W2154455877 hasIssue "15" @default.
• W2154455877 hasLocation W21544558771 @default.
• W2154455877 hasOpenAccess W2154455877 @default.
• W2154455877 hasPrimaryLocation W21544558771 @default.
• W2154455877 hasRelatedWork W1964840824 @default.

• next