FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154458839> ?p ?o ?g. }

• W2154458839 endingPage "913" @default.
• W2154458839 startingPage "900" @default.
• W2154458839 abstract "Vertebrate Hox genes display nested and overlapping patterns of expression. During mouse hindbrain development, Hoxb3 and Hoxb4 share an expression domain caudal to the boundary between rhombomeres 6 and 7. Transgenic analysis reveals that an enhancer (CR3) is shared between both genes and specifies this domain of overlap. Both the position of CR3 within the complex and its sequence are conserved from fish to mammals, suggesting it has a common role in regulating the vertebrate HoxB complex. CR3 mediates transcriptional activation by multiple Hox genes, including Hoxb4, Hoxd4, and Hoxb5 but not Hoxb1. It also functions as a selective HOX response element in Drosophila, where activation depends on Deformed, Sex combs reduced, and Antennapedia but not labial. Taken together, these data show that a Deformed/Hoxb4 autoregulatory loop has been conserved between mouse and Drosophila. In addition, these studies reveal the existence of positive cross-regulation and enhancer sharing as two mechanisms for reinforcing the overlapping expression domains of vertebrate Hox genes. In contrast, Drosophila Hox genes do not appear to share enhancers and where they overlap in expression, negative cross-regulatory interactions are observed. Therefore, despite many well documented aspects of Hox structural and functional conservation, there are mechanistic differences in Hox complex regulation between arthropods and vertebrates." @default.
• W2154458839 created "2016-06-24" @default.
• W2154458839 creator A5022732047 @default.
• W2154458839 creator A5029217631 @default.
• W2154458839 creator A5042444783 @default.
• W2154458839 creator A5078678178 @default.
• W2154458839 creator A5091176685 @default.
• W2154458839 date "1997-04-01" @default.
• W2154458839 modified "2023-09-26" @default.
• W2154458839 title "Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns." @default.
• W2154458839 cites W115531509 @default.
• W2154458839 cites W1513145417 @default.
• W2154458839 cites W1565800544 @default.
• W2154458839 cites W1568034086 @default.
• W2154458839 cites W1589289885 @default.
• W2154458839 cites W1769442001 @default.
• W2154458839 cites W1915103243 @default.
• W2154458839 cites W193683354 @default.
• W2154458839 cites W1941286715 @default.
• W2154458839 cites W1948479621 @default.
• W2154458839 cites W1964288202 @default.
• W2154458839 cites W1965117722 @default.
• W2154458839 cites W1972928782 @default.
• W2154458839 cites W1973912452 @default.
• W2154458839 cites W1974426489 @default.
• W2154458839 cites W1975905413 @default.
• W2154458839 cites W1983203736 @default.
• W2154458839 cites W1984844595 @default.
• W2154458839 cites W1986041519 @default.
• W2154458839 cites W1995576030 @default.
• W2154458839 cites W1999702908 @default.
• W2154458839 cites W2000871658 @default.
• W2154458839 cites W2006096663 @default.
• W2154458839 cites W2006788765 @default.
• W2154458839 cites W2008004759 @default.
• W2154458839 cites W2009851083 @default.
• W2154458839 cites W2012899113 @default.
• W2154458839 cites W2016686483 @default.
• W2154458839 cites W2016898440 @default.
• W2154458839 cites W2017279223 @default.
• W2154458839 cites W2020160255 @default.
• W2154458839 cites W2023003508 @default.
• W2154458839 cites W2024615596 @default.
• W2154458839 cites W2026346117 @default.
• W2154458839 cites W2030564922 @default.
• W2154458839 cites W2035297312 @default.
• W2154458839 cites W2038890085 @default.
• W2154458839 cites W2045232172 @default.
• W2154458839 cites W2048249977 @default.
• W2154458839 cites W2054160429 @default.
• W2154458839 cites W2055013769 @default.
• W2154458839 cites W2057433337 @default.
• W2154458839 cites W2059696301 @default.
• W2154458839 cites W2061191160 @default.
• W2154458839 cites W2066666893 @default.
• W2154458839 cites W2068446924 @default.
• W2154458839 cites W2068710848 @default.
• W2154458839 cites W2072212557 @default.
• W2154458839 cites W2072818545 @default.
• W2154458839 cites W2075832020 @default.
• W2154458839 cites W2076241945 @default.
• W2154458839 cites W2077241500 @default.
• W2154458839 cites W2079651862 @default.
• W2154458839 cites W2084767452 @default.
• W2154458839 cites W2091626902 @default.
• W2154458839 cites W2094226065 @default.
• W2154458839 cites W2096859263 @default.
• W2154458839 cites W2125161163 @default.
• W2154458839 cites W2128782542 @default.
• W2154458839 cites W2133279102 @default.
• W2154458839 cites W2139521310 @default.
• W2154458839 cites W214611139 @default.
• W2154458839 cites W2154073211 @default.
• W2154458839 cites W2159192458 @default.
• W2154458839 cites W2160620008 @default.
• W2154458839 cites W2167402042 @default.
• W2154458839 cites W2168847939 @default.
• W2154458839 cites W2169920445 @default.
• W2154458839 cites W2172006962 @default.
• W2154458839 cites W2191089640 @default.
• W2154458839 cites W2218155435 @default.
• W2154458839 cites W2276923998 @default.
• W2154458839 cites W2284517128 @default.
• W2154458839 cites W2292326240 @default.
• W2154458839 cites W2397079092 @default.
• W2154458839 cites W2416845977 @default.
• W2154458839 cites W2469766412 @default.
• W2154458839 cites W3208161905 @default.
• W2154458839 cites W33805216 @default.
• W2154458839 cites W4229918205 @default.
• W2154458839 cites W4256726956 @default.
• W2154458839 cites W4361805501 @default.
• W2154458839 doi "https://doi.org/10.1101/gad.11.7.900" @default.
• W2154458839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9106661" @default.
• W2154458839 hasPublicationYear "1997" @default.
• W2154458839 type Work @default.
• W2154458839 sameAs 2154458839 @default.
• W2154458839 citedByCount "253" @default.

• next