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- W2154459669 abstract "Abstract During infection, fungal pathogens activate virulence mechanisms, such as host adhesion, penetration and invasive growth. In the vascular wilt fungus Fusarium oxysporum, the mitogen-activated protein kinase Fmk1 is required for plant infection and controls processes such as cellophane penetration, vegetative hyphal fusion, or root adhesion. Here, we show that these virulence-related functions are repressed by the preferred nitrogen source ammonium and restored by treatment with l-methionine sulfoximine or rapamycin, two specific inhibitors of Gln synthetase and the protein kinase TOR, respectively. Deletion of the bZIP protein MeaB also resulted in nitrogen source–independent activation of virulence mechanisms. Activation of these functions did not require the global nitrogen regulator AreA, suggesting that MeaB-mediated repression of virulence functions does not act through inhibition of AreA. Tomato plants (Solanum lycopersicum) supplied with ammonium rather than nitrate showed a significant reduction in vascular wilt symptoms when infected with the wild type but not with the ΔmeaB strain. Nitrogen source also affected invasive growth in the rice blast fungus Magnaporthe oryzae and the wheat head blight pathogen Fusarium graminearum. We propose that a conserved nitrogen-responsive pathway might operate via TOR and MeaB to control virulence in plant pathogenic fungi." @default.
- W2154459669 created "2016-06-24" @default.
- W2154459669 creator A5021697703 @default.
- W2154459669 creator A5028975531 @default.
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- W2154459669 date "2010-07-01" @default.
- W2154459669 modified "2023-10-01" @default.
- W2154459669 title "A Nitrogen Response Pathway Regulates Virulence Functions in <i>Fusarium oxysporum</i> via the Protein Kinase TOR and the bZIP Protein MeaB " @default.
- W2154459669 cites W1509611593 @default.
- W2154459669 cites W1514354796 @default.
- W2154459669 cites W1614347411 @default.
- W2154459669 cites W165134962 @default.
- W2154459669 cites W1675434319 @default.
- W2154459669 cites W1747433277 @default.
- W2154459669 cites W1798414388 @default.
- W2154459669 cites W1962676038 @default.
- W2154459669 cites W1965901809 @default.
- W2154459669 cites W1974169319 @default.
- W2154459669 cites W1981025637 @default.
- W2154459669 cites W1982696528 @default.
- W2154459669 cites W1984860940 @default.
- W2154459669 cites W1989883408 @default.
- W2154459669 cites W1991807212 @default.
- W2154459669 cites W1998793813 @default.
- W2154459669 cites W1998871484 @default.
- W2154459669 cites W2000119789 @default.
- W2154459669 cites W2005744466 @default.
- W2154459669 cites W2006733565 @default.
- W2154459669 cites W2015630358 @default.
- W2154459669 cites W2033634300 @default.
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- W2154459669 cites W2098337864 @default.
- W2154459669 cites W2098497919 @default.
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- W2154459669 doi "https://doi.org/10.1105/tpc.110.075937" @default.
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