FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154467144> ?p ?o ?g. }

• W2154467144 endingPage "7321" @default.
• W2154467144 startingPage "7311" @default.
• W2154467144 abstract "Abstract Purpose: To evaluate the predictive value of the disintegrin and metalloproteinases, ADAM-9, ADAM-10, ADAM-11, and ADAM-12, and of the matrix metalloproteinases, MMP-2 and MMP-9, in patients with recurrent breast cancer treated with tamoxifen. Experimental Design: A retrospective study was done on 259 frozen specimens of estrogen receptor–positive primary breast carcinomas from patients who developed recurrent disease and were treated with tamoxifen as the first line of therapy. The expression levels of the biological factors were assessed by real-time quantitative reverse transcriptase PCR. Results: Using log-transformed continuous variables, increasing levels of ADAM-9 [odds ratio (OR) = 1.41; P = 0.015] and decreasing levels of MMP-9 (OR, 0.81; P = 0.035) predicted favorable disease control independent from the traditional predictive factors. Furthermore, when tumors were dichotomized at the median level of 70% tumor cell nuclei, our univariate analysis showed particularly strong results for the group of 153 patients with primary tumors containing 30% or more stromal cells. Although estrogen receptor levels lost their predictive power for this group of patients, high levels of ADAM-9 (OR, 1.59; P = 0.007) and ADAM-11 (OR, 1.65; P = 0.001) were significantly associated with a higher efficacy of tamoxifen therapy. Conclusions: Our results show that especially for primary tumors containing stromal elements, the assessment of mRNA expression levels of ADAM-9 and ADAM-11 could be useful to identify patients with recurrent breast cancer who are likely to benefit or fail from tamoxifen therapy." @default.
• W2154467144 created "2016-06-24" @default.
• W2154467144 creator A5002043418 @default.
• W2154467144 creator A5005328653 @default.
• W2154467144 creator A5015376412 @default.
• W2154467144 creator A5019431922 @default.
• W2154467144 creator A5041093711 @default.
• W2154467144 creator A5043655122 @default.
• W2154467144 creator A5066680524 @default.
• W2154467144 creator A5069964093 @default.
• W2154467144 creator A5071492651 @default.
• W2154467144 creator A5079825979 @default.
• W2154467144 date "2005-10-15" @default.
• W2154467144 modified "2023-09-26" @default.
• W2154467144 title "How ADAM-9 and ADAM-11 Differentially From Estrogen Receptor Predict Response to Tamoxifen Treatment in Patients with Recurrent Breast Cancer: a Retrospective Study" @default.
• W2154467144 cites W1605046409 @default.
• W2154467144 cites W1846747462 @default.
• W2154467144 cites W1965804235 @default.
• W2154467144 cites W1966442692 @default.
• W2154467144 cites W1976090068 @default.
• W2154467144 cites W1982092344 @default.
• W2154467144 cites W1983455542 @default.
• W2154467144 cites W1984064042 @default.
• W2154467144 cites W1989228411 @default.
• W2154467144 cites W1992269344 @default.
• W2154467144 cites W2016569614 @default.
• W2154467144 cites W2040077715 @default.
• W2154467144 cites W2043250294 @default.
• W2154467144 cites W2045432539 @default.
• W2154467144 cites W2052127481 @default.
• W2154467144 cites W2057459166 @default.
• W2154467144 cites W2058681718 @default.
• W2154467144 cites W2062349124 @default.
• W2154467144 cites W2078452075 @default.
• W2154467144 cites W2086398188 @default.
• W2154467144 cites W2087233429 @default.
• W2154467144 cites W2092023077 @default.
• W2154467144 cites W2092502812 @default.
• W2154467144 cites W2094984378 @default.
• W2154467144 cites W2103220829 @default.
• W2154467144 cites W2107696861 @default.
• W2154467144 cites W2132846837 @default.
• W2154467144 cites W2139688694 @default.
• W2154467144 cites W2141232624 @default.
• W2154467144 cites W2145837099 @default.
• W2154467144 cites W2146194904 @default.
• W2154467144 cites W2149683780 @default.
• W2154467144 cites W2151447010 @default.
• W2154467144 cites W2164258770 @default.
• W2154467144 cites W2166396916 @default.
• W2154467144 cites W2196919854 @default.
• W2154467144 cites W2227278468 @default.
• W2154467144 cites W2323421875 @default.
• W2154467144 cites W4255118237 @default.
• W2154467144 doi "https://doi.org/10.1158/1078-0432.ccr-05-0560" @default.
• W2154467144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16243802" @default.
• W2154467144 hasPublicationYear "2005" @default.
• W2154467144 type Work @default.
• W2154467144 sameAs 2154467144 @default.
• W2154467144 citedByCount "78" @default.
• W2154467144 countsByYear W21544671442012 @default.
• W2154467144 countsByYear W21544671442013 @default.
• W2154467144 countsByYear W21544671442014 @default.
• W2154467144 countsByYear W21544671442015 @default.
• W2154467144 countsByYear W21544671442016 @default.
• W2154467144 countsByYear W21544671442017 @default.
• W2154467144 countsByYear W21544671442018 @default.
• W2154467144 countsByYear W21544671442019 @default.
• W2154467144 countsByYear W21544671442020 @default.
• W2154467144 countsByYear W21544671442021 @default.
• W2154467144 countsByYear W21544671442022 @default.
• W2154467144 countsByYear W21544671442023 @default.
• W2154467144 crossrefType "journal-article" @default.
• W2154467144 hasAuthorship W2154467144A5002043418 @default.
• W2154467144 hasAuthorship W2154467144A5005328653 @default.
• W2154467144 hasAuthorship W2154467144A5015376412 @default.
• W2154467144 hasAuthorship W2154467144A5019431922 @default.
• W2154467144 hasAuthorship W2154467144A5041093711 @default.
• W2154467144 hasAuthorship W2154467144A5043655122 @default.
• W2154467144 hasAuthorship W2154467144A5066680524 @default.
• W2154467144 hasAuthorship W2154467144A5069964093 @default.
• W2154467144 hasAuthorship W2154467144A5071492651 @default.
• W2154467144 hasAuthorship W2154467144A5079825979 @default.
• W2154467144 hasConcept C121608353 @default.
• W2154467144 hasConcept C126322002 @default.
• W2154467144 hasConcept C143998085 @default.
• W2154467144 hasConcept C144301174 @default.
• W2154467144 hasConcept C167135981 @default.
• W2154467144 hasConcept C16930146 @default.
• W2154467144 hasConcept C2777164284 @default.
• W2154467144 hasConcept C2777176818 @default.
• W2154467144 hasConcept C38180746 @default.
• W2154467144 hasConcept C530470458 @default.
• W2154467144 hasConcept C71924100 @default.
• W2154467144 hasConcept C84606932 @default.
• W2154467144 hasConcept C98717036 @default.
• W2154467144 hasConceptScore W2154467144C121608353 @default.
• W2154467144 hasConceptScore W2154467144C126322002 @default.

• next