FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154486667> ?p ?o ?g. }

• W2154486667 abstract "The present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. The obtained microcapsules were discrete, spherical with free flowing properties and evaluated for particle size, shape, flow properties, wall thickness, drug encapsulation efficiency and in vitro release performance. The drug carrier interactions were investigated in solid state by FT-IR spectroscopy and scanning electron microscopy. The microcapsules with a narrow size range of 23-68 μm showed higher encapsulation efficiency. The selected microcapsule formulation, MC3 (Drug polymer ratio 1:4) was employed for gel formulation with a variety of carbopol polymers (carbopol-934, 940, 974 and 980) by mechanical stirring method in order to develop a sustained release microencapsulated metronidazole microcapsules-containing bioadhesive gel. The prepared bioadhesive gels were evaluated for pH, spreadability, extrudability, viscosity, vaginal irritation, in vitro drug release, bioadhesion, accelerated stability and in vitro drug release kinetic. In vitro experiments indicated a sustained release over 24 h and an acceptable bioadhesion quality for formulation F3. Hence, it can be concluded that the formulation F3 has potential to deliver metronidazole in a controlled and constant manner for prolong period over other formulations and can be adopted for a successful delivery of metronidazole for vaginal use." @default.
• W2154486667 created "2016-06-24" @default.
• W2154486667 creator A5002250631 @default.
• W2154486667 creator A5005393521 @default.
• W2154486667 creator A5027339360 @default.
• W2154486667 creator A5044273215 @default.
• W2154486667 date "2010-01-01" @default.
• W2154486667 modified "2023-09-24" @default.
• W2154486667 title "Development and characterization of bioadhesive gel of microencapsulated metronidazole for vaginal use." @default.
• W2154486667 cites W1566408227 @default.
• W2154486667 cites W1972198095 @default.
• W2154486667 cites W1975310638 @default.
• W2154486667 cites W2001240823 @default.
• W2154486667 cites W2001506217 @default.
• W2154486667 cites W2011308189 @default.
• W2154486667 cites W2040826651 @default.
• W2154486667 cites W2044853520 @default.
• W2154486667 cites W2057611248 @default.
• W2154486667 cites W2086130473 @default.
• W2154486667 cites W2094068371 @default.
• W2154486667 cites W2094682909 @default.
• W2154486667 cites W2106854568 @default.
• W2154486667 cites W2476270110 @default.
• W2154486667 cites W2489370198 @default.
• W2154486667 cites W2523000047 @default.
• W2154486667 cites W393707166 @default.
• W2154486667 cites W2461143472 @default.
• W2154486667 cites W2469326397 @default.
• W2154486667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3863435" @default.
• W2154486667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24363730" @default.
• W2154486667 hasPublicationYear "2010" @default.
• W2154486667 type Work @default.
• W2154486667 sameAs 2154486667 @default.
• W2154486667 citedByCount "11" @default.
• W2154486667 countsByYear W21544866672012 @default.
• W2154486667 countsByYear W21544866672013 @default.
• W2154486667 countsByYear W21544866672015 @default.
• W2154486667 countsByYear W21544866672016 @default.
• W2154486667 countsByYear W21544866672018 @default.
• W2154486667 countsByYear W21544866672019 @default.
• W2154486667 countsByYear W21544866672022 @default.
• W2154486667 crossrefType "journal-article" @default.
• W2154486667 hasAuthorship W2154486667A5002250631 @default.
• W2154486667 hasAuthorship W2154486667A5005393521 @default.
• W2154486667 hasAuthorship W2154486667A5027339360 @default.
• W2154486667 hasAuthorship W2154486667A5044273215 @default.
• W2154486667 hasConcept C127413603 @default.
• W2154486667 hasConcept C136229726 @default.
• W2154486667 hasConcept C147789679 @default.
• W2154486667 hasConcept C159985019 @default.
• W2154486667 hasConcept C171250308 @default.
• W2154486667 hasConcept C185592680 @default.
• W2154486667 hasConcept C187530423 @default.
• W2154486667 hasConcept C192562407 @default.
• W2154486667 hasConcept C2776035855 @default.
• W2154486667 hasConcept C2776634624 @default.
• W2154486667 hasConcept C2777396551 @default.
• W2154486667 hasConcept C2779820397 @default.
• W2154486667 hasConcept C42360764 @default.
• W2154486667 hasConcept C43617362 @default.
• W2154486667 hasConcept C501593827 @default.
• W2154486667 hasConcept C521977710 @default.
• W2154486667 hasConcept C55493867 @default.
• W2154486667 hasConcept C71924100 @default.
• W2154486667 hasConcept C77281830 @default.
• W2154486667 hasConceptScore W2154486667C127413603 @default.
• W2154486667 hasConceptScore W2154486667C136229726 @default.
• W2154486667 hasConceptScore W2154486667C147789679 @default.
• W2154486667 hasConceptScore W2154486667C159985019 @default.
• W2154486667 hasConceptScore W2154486667C171250308 @default.
• W2154486667 hasConceptScore W2154486667C185592680 @default.
• W2154486667 hasConceptScore W2154486667C187530423 @default.
• W2154486667 hasConceptScore W2154486667C192562407 @default.
• W2154486667 hasConceptScore W2154486667C2776035855 @default.
• W2154486667 hasConceptScore W2154486667C2776634624 @default.
• W2154486667 hasConceptScore W2154486667C2777396551 @default.
• W2154486667 hasConceptScore W2154486667C2779820397 @default.
• W2154486667 hasConceptScore W2154486667C42360764 @default.
• W2154486667 hasConceptScore W2154486667C43617362 @default.
• W2154486667 hasConceptScore W2154486667C501593827 @default.
• W2154486667 hasConceptScore W2154486667C521977710 @default.
• W2154486667 hasConceptScore W2154486667C55493867 @default.
• W2154486667 hasConceptScore W2154486667C71924100 @default.
• W2154486667 hasConceptScore W2154486667C77281830 @default.
• W2154486667 hasLocation W21544866671 @default.
• W2154486667 hasOpenAccess W2154486667 @default.
• W2154486667 hasPrimaryLocation W21544866671 @default.
• W2154486667 hasRelatedWork W1977922405 @default.
• W2154486667 hasRelatedWork W1983269317 @default.
• W2154486667 hasRelatedWork W1986876497 @default.
• W2154486667 hasRelatedWork W1997581486 @default.
• W2154486667 hasRelatedWork W2001846833 @default.
• W2154486667 hasRelatedWork W2022556642 @default.
• W2154486667 hasRelatedWork W2038245122 @default.
• W2154486667 hasRelatedWork W2039548676 @default.
• W2154486667 hasRelatedWork W2044853520 @default.
• W2154486667 hasRelatedWork W2086004942 @default.
• W2154486667 hasRelatedWork W2134762033 @default.
• W2154486667 hasRelatedWork W2142490405 @default.
• W2154486667 hasRelatedWork W2283079176 @default.

• next