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- W2154497098 abstract "The silencer information regulator (Sir) family of proteins has attracted much attention during the past decade due to its prominent role in metabolic homeostasis in mammals. The Sir1–4 proteins were first discovered in yeast as nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases, which through a gene silencing effect promoted longevity. The subsequent discovery of a homologous sirtuin (Sirt) family of proteins in the mammalian systems soon led to the realization that these molecules have beneficial effects in metabolism- and aging-related diseases. Through their concerted functions in the central nervous system, liver, pancreas, skeletal muscle, and adipose tissue, they regulate the body's metabolism. Sirt1, -6, and -7 exert their functions, predominantly, through a direct effect on nuclear transcription of genes involved in metabolism, whereas Sirt3–5 reside in the mitochondrial matrix and regulate various enzymes involved in the tricarboxylic acid and urea cycles, oxidative phosphorylation, as well as reactive oxygen species production. An interesting aspect of the functionality of sirtuin involves their regulation by the circadian rhythm, which affects their function via cyclically regulating systemic NAD + availability, further establishing the link of these proteins to metabolism. In this review, we will discuss the relation of sirtuins to NAD + metabolism, their mechanism of function, and their role in metabolism and mitochondrial functions. In addition, we will describe their effects in the cardiovascular and central nervous systems." @default.
- W2154497098 created "2016-06-24" @default.
- W2154497098 creator A5080243525 @default.
- W2154497098 date "2012-08-17" @default.
- W2154497098 modified "2023-10-17" @default.
- W2154497098 title "Sirtuins and Pyridine Nucleotides" @default.
- W2154497098 cites W1522919673 @default.
- W2154497098 cites W1523158326 @default.
- W2154497098 cites W1536757970 @default.
- W2154497098 cites W1541897964 @default.
- W2154497098 cites W1601570879 @default.
- W2154497098 cites W168383662 @default.
- W2154497098 cites W1926757795 @default.
- W2154497098 cites W1963554273 @default.
- W2154497098 cites W1963578989 @default.
- W2154497098 cites W1964059126 @default.
- W2154497098 cites W1968890500 @default.
- W2154497098 cites W1970277428 @default.
- W2154497098 cites W1971082641 @default.
- W2154497098 cites W1973901371 @default.
- W2154497098 cites W1974133264 @default.
- W2154497098 cites W1974890383 @default.
- W2154497098 cites W1974961331 @default.
- W2154497098 cites W1977014064 @default.
- W2154497098 cites W1978294146 @default.
- W2154497098 cites W1978548065 @default.
- W2154497098 cites W1979657807 @default.
- W2154497098 cites W1981549228 @default.
- W2154497098 cites W1982664954 @default.
- W2154497098 cites W1985941542 @default.
- W2154497098 cites W1986501172 @default.
- W2154497098 cites W1988007786 @default.
- W2154497098 cites W1990909446 @default.
- W2154497098 cites W1991246227 @default.
- W2154497098 cites W1991660337 @default.
- W2154497098 cites W1992598710 @default.
- W2154497098 cites W1993180847 @default.
- W2154497098 cites W1994994441 @default.
- W2154497098 cites W1995095187 @default.
- W2154497098 cites W1995188356 @default.
- W2154497098 cites W1996039273 @default.
- W2154497098 cites W1996821192 @default.
- W2154497098 cites W1997664301 @default.
- W2154497098 cites W2000177129 @default.
- W2154497098 cites W2000437193 @default.
- W2154497098 cites W2001257710 @default.
- W2154497098 cites W2001382962 @default.
- W2154497098 cites W2002811789 @default.
- W2154497098 cites W2004498697 @default.
- W2154497098 cites W2006173503 @default.
- W2154497098 cites W2007326142 @default.
- W2154497098 cites W2007846859 @default.
- W2154497098 cites W2010245357 @default.
- W2154497098 cites W2012147370 @default.
- W2154497098 cites W2013408977 @default.
- W2154497098 cites W2013841882 @default.
- W2154497098 cites W2014696454 @default.
- W2154497098 cites W2015080661 @default.
- W2154497098 cites W2016294119 @default.
- W2154497098 cites W2017525855 @default.
- W2154497098 cites W2017994898 @default.
- W2154497098 cites W2019106516 @default.
- W2154497098 cites W2019394625 @default.
- W2154497098 cites W2020304127 @default.
- W2154497098 cites W2020771162 @default.
- W2154497098 cites W2021432006 @default.
- W2154497098 cites W2021980639 @default.
- W2154497098 cites W2022267544 @default.
- W2154497098 cites W2023011167 @default.
- W2154497098 cites W2023650272 @default.
- W2154497098 cites W2025567662 @default.
- W2154497098 cites W2025668535 @default.
- W2154497098 cites W2027188918 @default.
- W2154497098 cites W2028363992 @default.
- W2154497098 cites W2037070180 @default.
- W2154497098 cites W2037678016 @default.
- W2154497098 cites W2039374791 @default.
- W2154497098 cites W2040625305 @default.
- W2154497098 cites W2041959419 @default.
- W2154497098 cites W2042500733 @default.
- W2154497098 cites W2042716686 @default.
- W2154497098 cites W2044578262 @default.
- W2154497098 cites W2052041317 @default.
- W2154497098 cites W2052751736 @default.
- W2154497098 cites W2055087351 @default.
- W2154497098 cites W2055969703 @default.
- W2154497098 cites W2056453168 @default.
- W2154497098 cites W2056673958 @default.
- W2154497098 cites W2056827933 @default.
- W2154497098 cites W2059750004 @default.
- W2154497098 cites W2060179186 @default.
- W2154497098 cites W2060814375 @default.
- W2154497098 cites W2066670499 @default.
- W2154497098 cites W2068281508 @default.
- W2154497098 cites W2069752613 @default.
- W2154497098 cites W2073988218 @default.
- W2154497098 cites W2074740541 @default.
- W2154497098 cites W2075043109 @default.