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• W2154504803 endingPage "2017" @default.
• W2154504803 startingPage "2000" @default.
• W2154504803 abstract "Narcolepsy is a chronic debilitating sleep disorder first described in the late 19th century. It is characterized by two major symptoms, excessive daytime sleepiness and cataplexy, and two so-called auxiliary symptoms, hypnagogic hallucinations and sleep paralysis. The final diagnosis relies on polysomnography showing the presence of sleep onset rapid eye movement periods (SOREMPs) during the multiple sleep latency test. The presence of HLA DQA1*0102-DQB1*0602 is supportive of the diagnosis. The pathophysiology of the disorder is still unknown but an imbalance between monoamines and acetylcholine is generally accepted. Recent findings in narcoleptic dogs, a natural model of narcolepsy, and in knockout mice revealed that a mutation of type 2 hypocretin receptor plays a major role in the etiology of narcolepsy. Up to now, no mutation has been found in humans except a case of early onset and atypical narcolepsy. However, a marked reduction of hypocretin type 1 has been found in the cerebrospinal fluid (CSF) of a majority of patients and a global loss of hypocretins was noted in post-mortem brain tissue of narcoleptic subjects. Conversely, no hypocretin neuron degeneration has been observed in the genetic form of narcolepsy in dogs but no trace of hypocretin was seen in the brain or the CSF in cases of sporadic canine narcolepsy. This suggests that different hypocretinergic mechanisms are involved in sporadic and genetic forms of canine narcolepsy. Treatment has not evolved significantly over the last few years. However, new drugs, such as hypocretin agonists, are currently being developed.After the discovery of the type 2 hypocretin receptor mutation in canine narcolepsy and the finding of a CSF hypocretin-1 deficiency in human narcolepsy, the major stream of research has involved the hypocretinergic system. However, other lines of research deserve to be pursued simultaneously, in view of comprehensive advancements in the understanding of narcolepsy." @default.
• W2154504803 created "2016-06-24" @default.
• W2154504803 creator A5008480675 @default.
• W2154504803 creator A5063275477 @default.
• W2154504803 creator A5075290723 @default.
• W2154504803 date "2003-11-01" @default.
• W2154504803 modified "2023-10-18" @default.
• W2154504803 title "Clinical aspects and pathophysiology of narcolepsy" @default.
• W2154504803 cites W102510518 @default.
• W2154504803 cites W11451662 @default.
• W2154504803 cites W121385500 @default.
• W2154504803 cites W127014378 @default.
• W2154504803 cites W135510326 @default.
• W2154504803 cites W137899464 @default.
• W2154504803 cites W1457009120 @default.
• W2154504803 cites W1471036057 @default.
• W2154504803 cites W1519232679 @default.
• W2154504803 cites W1538619854 @default.
• W2154504803 cites W1561443084 @default.
• W2154504803 cites W1596409175 @default.
• W2154504803 cites W1627229807 @default.
• W2154504803 cites W172600783 @default.
• W2154504803 cites W1856180860 @default.
• W2154504803 cites W193039664 @default.
• W2154504803 cites W1963609767 @default.
• W2154504803 cites W1964502071 @default.
• W2154504803 cites W1965976300 @default.
• W2154504803 cites W1967884630 @default.
• W2154504803 cites W1968974329 @default.
• W2154504803 cites W1969290948 @default.
• W2154504803 cites W1971234243 @default.
• W2154504803 cites W1973121908 @default.
• W2154504803 cites W1976275692 @default.
• W2154504803 cites W1977887519 @default.
• W2154504803 cites W1978592880 @default.
• W2154504803 cites W1980789028 @default.
• W2154504803 cites W1983298714 @default.
• W2154504803 cites W1985048695 @default.
• W2154504803 cites W1986849909 @default.
• W2154504803 cites W1992850027 @default.
• W2154504803 cites W1998101177 @default.
• W2154504803 cites W1999290258 @default.
• W2154504803 cites W1999506197 @default.
• W2154504803 cites W2002801505 @default.
• W2154504803 cites W2003600001 @default.
• W2154504803 cites W2004323271 @default.
• W2154504803 cites W2005715848 @default.
• W2154504803 cites W2005837050 @default.
• W2154504803 cites W2007702485 @default.
• W2154504803 cites W2009037172 @default.
• W2154504803 cites W2015251580 @default.
• W2154504803 cites W2018013977 @default.
• W2154504803 cites W2019153798 @default.
• W2154504803 cites W2021069417 @default.
• W2154504803 cites W2021759365 @default.
• W2154504803 cites W2022260697 @default.
• W2154504803 cites W2024741560 @default.
• W2154504803 cites W2025495766 @default.
• W2154504803 cites W2026849823 @default.
• W2154504803 cites W2026940382 @default.
• W2154504803 cites W2027740042 @default.
• W2154504803 cites W2028344710 @default.
• W2154504803 cites W2029582941 @default.
• W2154504803 cites W2031716644 @default.
• W2154504803 cites W2032009104 @default.
• W2154504803 cites W2034157067 @default.
• W2154504803 cites W2034218422 @default.
• W2154504803 cites W2034370950 @default.
• W2154504803 cites W2035288859 @default.
• W2154504803 cites W2036768537 @default.
• W2154504803 cites W2037675204 @default.
• W2154504803 cites W2038003772 @default.
• W2154504803 cites W2040032939 @default.
• W2154504803 cites W2041649541 @default.
• W2154504803 cites W2044391268 @default.
• W2154504803 cites W2044769869 @default.
• W2154504803 cites W2046134526 @default.
• W2154504803 cites W2048573200 @default.
• W2154504803 cites W2048970158 @default.
• W2154504803 cites W2049088920 @default.
• W2154504803 cites W2049726998 @default.
• W2154504803 cites W2051540127 @default.
• W2154504803 cites W2052714787 @default.
• W2154504803 cites W2053286463 @default.
• W2154504803 cites W2053381667 @default.
• W2154504803 cites W2054088581 @default.
• W2154504803 cites W2055679275 @default.
• W2154504803 cites W2059854592 @default.
• W2154504803 cites W2060212263 @default.
• W2154504803 cites W2064544911 @default.
• W2154504803 cites W2065192322 @default.
• W2154504803 cites W2069037326 @default.
• W2154504803 cites W2072154498 @default.
• W2154504803 cites W2072926066 @default.
• W2154504803 cites W2073960829 @default.
• W2154504803 cites W2078725934 @default.
• W2154504803 cites W2082644721 @default.
• W2154504803 cites W2084801512 @default.

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