FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154506031> ?p ?o ?g. }

• W2154506031 endingPage "419" @default.
• W2154506031 startingPage "411" @default.
• W2154506031 abstract "The clinical application of gene silencing mediated by small interfering RNA (siRNA) has been limited by the lack of efficient and safe carriers. Phospholipid modification of low molecular weight polyethylenimine (PEI 1.8 kDa) dramatically increased its gene down-regulation capacity while keeping cytotoxicity levels low. The silencing efficacy was highly dependent on the nature of the lipid grafted to PEI and the polymer/siRNA ratio employed. Phosphoethanolamine (DOPE and DPPE) and phosphocholine (PC) conjugation did not change the physicochemical properties and siRNA binding capacity of PEI complexes but had a large impact on their transfection and ability to down-regulate Green Fluorescent Protein (GFP) expression (60%, 30% and 5% decrease of GFP expression respectively). We found that the micelle-forming structure of DOPE and DPPE-PEI dramatically changed PEI's interaction with cell membranes and played a key role in promoting PEI 1.8 kDa transfection, completely ineffective in the absence of the lipid modification.While siRNA-based gene silencing methods could have numerous clinical applications, efficient delivery remains a major challenge. This team reports that DOPE-PEI and DPPE-PEI based micelle-forming nanostructures may be able to provide an efficient vector for siRNA transfection." @default.
• W2154506031 created "2016-06-24" @default.
• W2154506031 creator A5011840568 @default.
• W2154506031 creator A5014576744 @default.
• W2154506031 creator A5016214053 @default.
• W2154506031 creator A5034153270 @default.
• W2154506031 creator A5038150974 @default.
• W2154506031 creator A5070850971 @default.
• W2154506031 creator A5074966571 @default.
• W2154506031 creator A5084391530 @default.
• W2154506031 date "2014-02-01" @default.
• W2154506031 modified "2023-09-27" @default.
• W2154506031 title "Phospholipid-modified polyethylenimine-based nanopreparations for siRNA–mediated gene silencing: Implications for transfection and the role of lipid components" @default.
• W2154506031 cites W1968263631 @default.
• W2154506031 cites W1973350289 @default.
• W2154506031 cites W1974605548 @default.
• W2154506031 cites W1974661973 @default.
• W2154506031 cites W1979839164 @default.
• W2154506031 cites W1982556392 @default.
• W2154506031 cites W1985882425 @default.
• W2154506031 cites W1995956587 @default.
• W2154506031 cites W2000651827 @default.
• W2154506031 cites W2001577610 @default.
• W2154506031 cites W2017111116 @default.
• W2154506031 cites W2017307273 @default.
• W2154506031 cites W2021082805 @default.
• W2154506031 cites W2032506474 @default.
• W2154506031 cites W2040349932 @default.
• W2154506031 cites W2050018254 @default.
• W2154506031 cites W2058506859 @default.
• W2154506031 cites W2064585988 @default.
• W2154506031 cites W2067302150 @default.
• W2154506031 cites W2069879613 @default.
• W2154506031 cites W2072016801 @default.
• W2154506031 cites W2074133546 @default.
• W2154506031 cites W2078748900 @default.
• W2154506031 cites W2079445254 @default.
• W2154506031 cites W2083100535 @default.
• W2154506031 cites W2090458823 @default.
• W2154506031 cites W2091211551 @default.
• W2154506031 cites W2112073236 @default.
• W2154506031 cites W2116162518 @default.
• W2154506031 cites W2120862472 @default.
• W2154506031 cites W2143875501 @default.
• W2154506031 cites W2146871305 @default.
• W2154506031 cites W2149236646 @default.
• W2154506031 cites W2168045030 @default.
• W2154506031 cites W2212287095 @default.
• W2154506031 doi "https://doi.org/10.1016/j.nano.2013.07.016" @default.
• W2154506031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3916950" @default.
• W2154506031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23928214" @default.
• W2154506031 hasPublicationYear "2014" @default.
• W2154506031 type Work @default.
• W2154506031 sameAs 2154506031 @default.
• W2154506031 citedByCount "37" @default.
• W2154506031 countsByYear W21545060312014 @default.
• W2154506031 countsByYear W21545060312015 @default.
• W2154506031 countsByYear W21545060312016 @default.
• W2154506031 countsByYear W21545060312017 @default.
• W2154506031 countsByYear W21545060312018 @default.
• W2154506031 countsByYear W21545060312019 @default.
• W2154506031 countsByYear W21545060312020 @default.
• W2154506031 countsByYear W21545060312021 @default.
• W2154506031 countsByYear W21545060312022 @default.
• W2154506031 crossrefType "journal-article" @default.
• W2154506031 hasAuthorship W2154506031A5011840568 @default.
• W2154506031 hasAuthorship W2154506031A5014576744 @default.
• W2154506031 hasAuthorship W2154506031A5016214053 @default.
• W2154506031 hasAuthorship W2154506031A5034153270 @default.
• W2154506031 hasAuthorship W2154506031A5038150974 @default.
• W2154506031 hasAuthorship W2154506031A5070850971 @default.
• W2154506031 hasAuthorship W2154506031A5074966571 @default.
• W2154506031 hasAuthorship W2154506031A5084391530 @default.
• W2154506031 hasBestOaLocation W21545060312 @default.
• W2154506031 hasConcept C104317684 @default.
• W2154506031 hasConcept C109316439 @default.
• W2154506031 hasConcept C119056186 @default.
• W2154506031 hasConcept C12554922 @default.
• W2154506031 hasConcept C135983454 @default.
• W2154506031 hasConcept C142613039 @default.
• W2154506031 hasConcept C153911025 @default.
• W2154506031 hasConcept C166703698 @default.
• W2154506031 hasConcept C185592680 @default.
• W2154506031 hasConcept C202751555 @default.
• W2154506031 hasConcept C22615655 @default.
• W2154506031 hasConcept C2775925850 @default.
• W2154506031 hasConcept C40767141 @default.
• W2154506031 hasConcept C49923114 @default.
• W2154506031 hasConcept C54009773 @default.
• W2154506031 hasConcept C55493867 @default.
• W2154506031 hasConcept C67705224 @default.
• W2154506031 hasConcept C86803240 @default.
• W2154506031 hasConcept C92087593 @default.
• W2154506031 hasConcept C95444343 @default.
• W2154506031 hasConceptScore W2154506031C104317684 @default.
• W2154506031 hasConceptScore W2154506031C109316439 @default.
• W2154506031 hasConceptScore W2154506031C119056186 @default.
• W2154506031 hasConceptScore W2154506031C12554922 @default.

• next