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• W2154560243 endingPage "2704" @default.
• W2154560243 startingPage "2696" @default.
• W2154560243 abstract "Using single molecule force spectroscopy we examine the response of heparin chains to mechanical stretching. We find that at forces below 200 pN heparin behaves as a simple entropic spring. At approximately 200 pN heparin displays a large enthalpic elasticity, which is evident as a pronounced plateau in the force-extension relationship. We determine that this enthalpic elasticity is produced by sugar rings of heparin flipping to more energetic and more extended conformations. We estimate that in vivo, the forces which stretch heparin are comparable to the forces that trigger conformational transitions in our single molecule atomic force microscopy measurements. We hypothesize that these conformational transitions have biological significance in that they provide a mechanism to finely regulate the affinity of various ligands toward heparin, for example, in secretory granules undergoing exocytosis and during the mechanical interactions between cells and the extracellular matrix." @default.
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• W2154560243 date "2003-10-01" @default.
• W2154560243 modified "2023-09-24" @default.
• W2154560243 title "The Force-Driven Conformations of Heparin Studied with Single Molecule Force Microscopy" @default.
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• W2154560243 doi "https://doi.org/10.1016/s0006-3495(03)74692-x" @default.
• W2154560243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1303493" @default.
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