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- W2154564423 endingPage "87" @default.
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- W2154564423 abstract "Patients receiving allopurinol are at risk of developing the allopurinol hypersensitivity syndrome, an immunologic reaction to the drug, characterized by multiple abnormalities such as fever, rash, decreased renal function, hepatocellular injury, leukocytosis, and eosinophilia. The records of 8 patients with the allopurinol hypersensitivity syndrome evaluated at the Downstate Medical Center hospitals and an additional 72 patients described in the literature were reviewed. All were seriously ill. Three of the 8 patients at the Downstate Medical Center hospitals died as a result of allopurinol hypersensitivity; 19 of the 72 previously described patients also died from consequences of taking the drug. Only 1 of our 8 patients with allopurinol hypersensitivity was given allopurinol for an appropriate reason. Eight of the 59 previously described patients on whom there was adequate information had legitimate indications for allopurinol therapy. Severe, often fatal iatrogenic disease occurred unnecessarily in the others." @default.
- W2154564423 created "2016-06-24" @default.
- W2154564423 creator A5036594762 @default.
- W2154564423 creator A5052490987 @default.
- W2154564423 date "1986-01-01" @default.
- W2154564423 modified "2023-10-14" @default.
- W2154564423 title "The allopurinol hypersensitivity syndrome. Unnecessary morbidity and mortality" @default.
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- W2154564423 doi "https://doi.org/10.1002/art.1780290111" @default.
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