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• W2154565979 abstract "Preliminary screening of the Malagasy plant Combretum albiflorum for compounds attenuating the production of quorum sensing (QS)-controlled virulence factors in bacteria led to the identification of active fractions containing flavonoids. In the present study, several flavonoids belonging to the flavone, flavanone, flavonol and chalcone structural groups were screened for their capacity to reduce the production of QS-controlled factors in the opportunistic pathogen Pseudomonas aeruginosa (strain PAO1). Flavanones (i.e. naringenin, eriodictyol and taxifolin) significantly reduced the production of pyocyanin and elastase in P. aeruginosa without affecting bacterial growth. Consistently, naringenin and taxifolin reduced the expression of several QS-controlled genes (i.e. lasI , lasR , rhlI , rhlR , lasA , lasB , phzA1 and rhlA ) in P. aeruginosa PAO1. Naringenin also dramatically reduced the production of the acylhomoserine lactones N -(3-oxododecanoyl)- l -homoserine lactone (3-oxo-C12-HSL) and N -butanoyl- l -homoserine lactone (C4-HSL), which is driven by the lasI and rhlI gene products, respectively. In addition, using mutant strains deficient for autoinduction (Δ lasI and Δ rhlI ) and LasR- and RhlR-based biosensors, it was shown that QS inhibition by naringenin not only is the consequence of a reduced production of autoinduction compounds but also results from a defect in the proper functioning of the RlhR–C4-HSL complex. Widely distributed in the plant kingdom, flavonoids are known for their numerous and determinant roles in plant physiology, plant development and in the success of plant–rhizobia interactions, but, as shown here, some of them also have a role as inhibitors of the virulence of pathogenic bacteria by interfering with QS mechanisms." @default.
• W2154565979 created "2016-06-24" @default.
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• W2154565979 date "2011-07-01" @default.
• W2154565979 modified "2023-10-18" @default.
• W2154565979 title "The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1" @default.
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• W2154565979 doi "https://doi.org/10.1099/mic.0.049338-0" @default.
• W2154565979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21546585" @default.
• W2154565979 hasPublicationYear "2011" @default.
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