Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154581555> ?p ?o ?g. }
- W2154581555 endingPage "3775" @default.
- W2154581555 startingPage "3764" @default.
- W2154581555 abstract "The orexigenic and anabolic effects induced by ghrelin and the synthetic GH secretagogues (GHSs) are thought to positively contribute to therapeutic approaches and the adjunct treatment of a number of diseases associated with muscle wasting such as cachexia and sarcopenia. However, many questions about the potential utility and safety of GHSs in both therapy and skeletal muscle function remain unanswered. By using fura-2 cytofluorimetric technique, we determined the acute effects of ghrelin, as well as of peptidyl and nonpeptidyl synthetic GHSs on calcium homeostasis, a critical biomarker of muscle function, in isolated tendon-to-tendon male rat skeletal muscle fibers. The synthetic nonpeptidyl GHSs, but not peptidyl ghrelin and hexarelin, were able to significantly increase resting cytosolic calcium [Ca²⁺]i. The nonpeptidyl GHS-induced [Ca²⁺]i increase was independent of GHS-receptor 1a but was antagonized by both thapsigargin/caffeine and cyclosporine A, indicating the involvement of the sarcoplasmic reticulum and mitochondria. Evaluation of the effects of a pseudopeptidyl GHS and a nonpeptidyl antagonist of the GHS-receptor 1a together with a drug-modeling study suggest the conclusion that the lipophilic nonpeptidyl structure of the tested compounds is the key chemical feature crucial for the GHS-induced calcium alterations in the skeletal muscle. Thus, synthetic GHSs can have different effects on skeletal muscle fibers depending on their molecular structures. The calcium homeostasis dysregulation specifically induced by the nonpeptidyl GHSs used in this study could potentially counteract the beneficial effects associated with these drugs in the treatment of muscle wasting of cachexia- or other age-related disorders." @default.
- W2154581555 created "2016-06-24" @default.
- W2154581555 creator A5026407702 @default.
- W2154581555 creator A5026741989 @default.
- W2154581555 creator A5043399255 @default.
- W2154581555 creator A5050995769 @default.
- W2154581555 creator A5051256686 @default.
- W2154581555 creator A5058714999 @default.
- W2154581555 creator A5060219918 @default.
- W2154581555 creator A5069147436 @default.
- W2154581555 creator A5075475458 @default.
- W2154581555 creator A5076976446 @default.
- W2154581555 date "2013-10-01" @default.
- W2154581555 modified "2023-10-18" @default.
- W2154581555 title "Growth Hormone Secretagogues Exert Differential Effects on Skeletal Muscle Calcium Homeostasis in Male Rats Depending on the Peptidyl/Nonpeptidyl Structure" @default.
- W2154581555 cites W116341769 @default.
- W2154581555 cites W1485297825 @default.
- W2154581555 cites W1594223323 @default.
- W2154581555 cites W1746209167 @default.
- W2154581555 cites W1849819493 @default.
- W2154581555 cites W1967723281 @default.
- W2154581555 cites W1970831868 @default.
- W2154581555 cites W1971484222 @default.
- W2154581555 cites W1971526727 @default.
- W2154581555 cites W1971743791 @default.
- W2154581555 cites W1977771547 @default.
- W2154581555 cites W1981061176 @default.
- W2154581555 cites W1987235632 @default.
- W2154581555 cites W1992319269 @default.
- W2154581555 cites W1994629009 @default.
- W2154581555 cites W1996236195 @default.
- W2154581555 cites W1998514047 @default.
- W2154581555 cites W1999304828 @default.
- W2154581555 cites W2000650296 @default.
- W2154581555 cites W2001077637 @default.
- W2154581555 cites W2002697895 @default.
- W2154581555 cites W2002886956 @default.
- W2154581555 cites W2005864976 @default.
- W2154581555 cites W2009707449 @default.
- W2154581555 cites W2015686095 @default.
- W2154581555 cites W2016527088 @default.
- W2154581555 cites W2016803682 @default.
- W2154581555 cites W2022751237 @default.
- W2154581555 cites W2035600501 @default.
- W2154581555 cites W2041690080 @default.
- W2154581555 cites W2042597742 @default.
- W2154581555 cites W2055142765 @default.
- W2154581555 cites W2058695279 @default.
- W2154581555 cites W2063053474 @default.
- W2154581555 cites W2063416479 @default.
- W2154581555 cites W2065918427 @default.
- W2154581555 cites W2068453159 @default.
- W2154581555 cites W2080426718 @default.
- W2154581555 cites W2086450610 @default.
- W2154581555 cites W2089800528 @default.
- W2154581555 cites W2090205374 @default.
- W2154581555 cites W2094896667 @default.
- W2154581555 cites W2099250011 @default.
- W2154581555 cites W2103010974 @default.
- W2154581555 cites W2108122320 @default.
- W2154581555 cites W2109993485 @default.
- W2154581555 cites W2110060107 @default.
- W2154581555 cites W2111278167 @default.
- W2154581555 cites W2111934536 @default.
- W2154581555 cites W2115801893 @default.
- W2154581555 cites W2120901082 @default.
- W2154581555 cites W2121135722 @default.
- W2154581555 cites W2129389766 @default.
- W2154581555 cites W2130520559 @default.
- W2154581555 cites W2130707394 @default.
- W2154581555 cites W2131954956 @default.
- W2154581555 cites W2141260882 @default.
- W2154581555 cites W2141361742 @default.
- W2154581555 cites W2142884389 @default.
- W2154581555 cites W2151012533 @default.
- W2154581555 cites W2155022809 @default.
- W2154581555 cites W2163865122 @default.
- W2154581555 cites W2168862718 @default.
- W2154581555 cites W2417201347 @default.
- W2154581555 doi "https://doi.org/10.1210/en.2013-1334" @default.
- W2154581555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23836033" @default.
- W2154581555 hasPublicationYear "2013" @default.
- W2154581555 type Work @default.
- W2154581555 sameAs 2154581555 @default.
- W2154581555 citedByCount "10" @default.
- W2154581555 countsByYear W21545815552014 @default.
- W2154581555 countsByYear W21545815552017 @default.
- W2154581555 countsByYear W21545815552019 @default.
- W2154581555 countsByYear W21545815552020 @default.
- W2154581555 countsByYear W21545815552021 @default.
- W2154581555 countsByYear W21545815552023 @default.
- W2154581555 crossrefType "journal-article" @default.
- W2154581555 hasAuthorship W2154581555A5026407702 @default.
- W2154581555 hasAuthorship W2154581555A5026741989 @default.
- W2154581555 hasAuthorship W2154581555A5043399255 @default.
- W2154581555 hasAuthorship W2154581555A5050995769 @default.
- W2154581555 hasAuthorship W2154581555A5051256686 @default.
- W2154581555 hasAuthorship W2154581555A5058714999 @default.