FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154582522> ?p ?o ?g. }

• W2154582522 endingPage "313" @default.
• W2154582522 startingPage "307" @default.
• W2154582522 abstract "Mycophenolic acid (MPA) is the active form of mycophenolate mofetil (MMF), which is currently used off-label as immunosuppressive therapy in childhood-onset SLE (cSLE). The objectives of this study were to (1) characterize the pharmacokinetics (MPA-PK) and pharmacodynamics (MPA-PD) of MPA and (2) explore the relationship between MPA-PK and cSLE disease activity. MPA-PK [area under the curve from 0-12 hours (AUC0-12)] and MPA-PD [inosine-monophosphate dehydrogenase (IMPDH) activity] were evaluated in cSLE patients on stable MMF dosing. Change in SLE disease activity while on MMF therapy was measured using the British Isles Lupus Assessment Group (BILAG) index. A total of 19 AUC0-12 and 10 IMPDH activity profiles were included in the analysis. Large interpatient variability in MPA exposure (AUC0-12) was observed (mean ± SE: 32 ± 4.2 mg h/L; coefficient of variation: 57%). Maximum MPA serum concentrations coincided with maximum IMPDH inhibition. AUC0-12 and weight-adjusted MMF dosing were only moderately correlated (r = 0.56, P = 0.01). An AUC0-12 of ≥30 mg h/L was associated with decreased BILAG scores while on MMF therapy (P = 0.002). Weight-adjusted MMF dosing alone does not reliably allow for the prediction of exposure to biologically active MPA in cSLE. Individualized dosing considering MPA-PK appears warranted as this allows for better estimation of immunologic suppression (IMPDH activity). Additional controlled studies are necessary to confirm that an MPA AUC0-12 of at least 30 mg h/L is required for cSLE improvement." @default.
• W2154582522 created "2016-06-24" @default.
• W2154582522 creator A5002172790 @default.
• W2154582522 creator A5005854905 @default.
• W2154582522 creator A5013881333 @default.
• W2154582522 creator A5021386589 @default.
• W2154582522 creator A5030180190 @default.
• W2154582522 creator A5033575005 @default.
• W2154582522 creator A5040060343 @default.
• W2154582522 creator A5052819935 @default.
• W2154582522 creator A5068653614 @default.
• W2154582522 creator A5081050294 @default.
• W2154582522 date "2011-02-01" @default.
• W2154582522 modified "2023-10-16" @default.
• W2154582522 title "Pharmacokinetics and Pharmacodynamics of Mycophenolic Acid and Their Relation to Response to Therapy of Childhood-Onset Systemic Lupus Erythematosus" @default.
• W2154582522 cites W1485674043 @default.
• W2154582522 cites W1752799444 @default.
• W2154582522 cites W1971387671 @default.
• W2154582522 cites W1972027639 @default.
• W2154582522 cites W1973433723 @default.
• W2154582522 cites W1978259933 @default.
• W2154582522 cites W1987132648 @default.
• W2154582522 cites W1994502792 @default.
• W2154582522 cites W1996853835 @default.
• W2154582522 cites W2002073330 @default.
• W2154582522 cites W2002991702 @default.
• W2154582522 cites W2005229698 @default.
• W2154582522 cites W2009560087 @default.
• W2154582522 cites W2026162105 @default.
• W2154582522 cites W2026334098 @default.
• W2154582522 cites W2039913375 @default.
• W2154582522 cites W2048269602 @default.
• W2154582522 cites W2055591899 @default.
• W2154582522 cites W2061904336 @default.
• W2154582522 cites W2067353313 @default.
• W2154582522 cites W2069277333 @default.
• W2154582522 cites W2070205742 @default.
• W2154582522 cites W2070527591 @default.
• W2154582522 cites W2074285718 @default.
• W2154582522 cites W2074567821 @default.
• W2154582522 cites W2077585193 @default.
• W2154582522 cites W2080892008 @default.
• W2154582522 cites W2085178500 @default.
• W2154582522 cites W2089150380 @default.
• W2154582522 cites W2089730036 @default.
• W2154582522 cites W2089926549 @default.
• W2154582522 cites W2093203039 @default.
• W2154582522 cites W2108821399 @default.
• W2154582522 cites W2116626206 @default.
• W2154582522 cites W2119644483 @default.
• W2154582522 cites W2125018526 @default.
• W2154582522 cites W2132244428 @default.
• W2154582522 cites W2138635241 @default.
• W2154582522 cites W2141502494 @default.
• W2154582522 cites W2146203649 @default.
• W2154582522 cites W2324505043 @default.
• W2154582522 cites W2336764264 @default.
• W2154582522 cites W2413111484 @default.
• W2154582522 cites W2415034621 @default.
• W2154582522 cites W2624408156 @default.
• W2154582522 cites W572973386 @default.
• W2154582522 doi "https://doi.org/10.1016/j.semarthrit.2010.05.007" @default.
• W2154582522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3021770" @default.
• W2154582522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20655577" @default.
• W2154582522 hasPublicationYear "2011" @default.
• W2154582522 type Work @default.
• W2154582522 sameAs 2154582522 @default.
• W2154582522 citedByCount "50" @default.
• W2154582522 countsByYear W21545825222012 @default.
• W2154582522 countsByYear W21545825222013 @default.
• W2154582522 countsByYear W21545825222014 @default.
• W2154582522 countsByYear W21545825222015 @default.
• W2154582522 countsByYear W21545825222016 @default.
• W2154582522 countsByYear W21545825222017 @default.
• W2154582522 countsByYear W21545825222018 @default.
• W2154582522 countsByYear W21545825222019 @default.
• W2154582522 countsByYear W21545825222020 @default.
• W2154582522 countsByYear W21545825222021 @default.
• W2154582522 countsByYear W21545825222022 @default.
• W2154582522 countsByYear W21545825222023 @default.
• W2154582522 crossrefType "journal-article" @default.
• W2154582522 hasAuthorship W2154582522A5002172790 @default.
• W2154582522 hasAuthorship W2154582522A5005854905 @default.
• W2154582522 hasAuthorship W2154582522A5013881333 @default.
• W2154582522 hasAuthorship W2154582522A5021386589 @default.
• W2154582522 hasAuthorship W2154582522A5030180190 @default.
• W2154582522 hasAuthorship W2154582522A5033575005 @default.
• W2154582522 hasAuthorship W2154582522A5040060343 @default.
• W2154582522 hasAuthorship W2154582522A5052819935 @default.
• W2154582522 hasAuthorship W2154582522A5068653614 @default.
• W2154582522 hasAuthorship W2154582522A5081050294 @default.
• W2154582522 hasBestOaLocation W21545825222 @default.
• W2154582522 hasConcept C111113717 @default.
• W2154582522 hasConcept C112705442 @default.
• W2154582522 hasConcept C126322002 @default.
• W2154582522 hasConcept C2776912625 @default.
• W2154582522 hasConcept C2777288759 @default.
• W2154582522 hasConcept C2778033501 @default.

• next