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- W2154606918 abstract "Evaluation of: McLaughlin VV., Sitbon O., Badesch DB. et al. Survival with first-line bosentan in patients with primary pulmonary hypertension. Eur. Respir. J. 25, 244–249 (2005). Primary pulmonary hypertension is a rare life-threatening form of pulmonary arterial hypertension. Several pharmacologic classes have recently become available for primary pulmonary hypertension treatment – prostacyclin and prostacyclin derivatives, endothelin receptor antagonists and phosphodiesterase inhibitors. Bosentan (Tracleer®) is an oral dual-endothelin receptor antagonist approved in Europe and North America for the treatment of pulmonary arterial hypertension. Several studies focused on the efficacy and safety of bosentan as an add-on or first-line therapy in primary pulmonary hypertension and pulmonary arterial hypertension related with connective tissue diseases. The current study assesses the impact of first-line bosentan therapy on the survival of primary pulmonary hypertension patients, compares it with a predicte..." @default.
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- W2154606918 date "2005-11-01" @default.
- W2154606918 modified "2023-09-25" @default.
- W2154606918 title "Bosentan for treatment of pulmonary arterial hypertension (I)" @default.
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- W2154606918 doi "https://doi.org/10.2217/14750708.2.6.843" @default.
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