FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154617657> ?p ?o ?g. }

• W2154617657 endingPage "496" @default.
• W2154617657 startingPage "486" @default.
• W2154617657 abstract "Accurate determination of the plasma input function (IF) is essential for absolute quantification of physiological parameters in positron emission tomography (PET). However, it requires an invasive and tedious procedure of arterial blood sampling that is challenging in mice because of the limited blood volume. In this study, a hybrid modeling approach is proposed to estimate the plasma IF of 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) in mice using accumulated radioactivity in urinary bladder together with a single late-time blood sample measurement. Dynamic PET scans were performed on nine isoflurane-anesthetized male C57BL/6 mice after a bolus injection of [18F]FDG at the lateral caudal vein. During a 60- or 90-min scan, serial blood samples were taken from the femoral artery. Image data were reconstructed using filtered backprojection with computed tomography-based attenuation correction. Total accumulated radioactivity in the urinary bladder at late times was fitted to a renal compartmental model with the last blood sample and a one-exponential function that described the [18F]FDG clearance in blood. Multiple late-time blood sample estimates were calculated by the blood [18F]FDG clearance equation. A sum of four-exponentials was assumed for the plasma IF that served as a forcing function to all tissues. The estimated plasma IF was obtained by simultaneously fitting the [18F]FDG model to the time–activity curves (TACs) of liver and muscle and the forcing function to early (0–1 min) left-ventricle data (corrected for delay, dispersion, partial-volume effects, and erythrocyte uptake) and the late-time blood estimates. Using only the blood sample collected at the end of the study to estimate the IF and the use of liver TAC as an alternative IF were also investigated. The area under the plasma IFs calculated for all studies using the hybrid approach was not significantly different from that using all blood samples. [18F]FDG uptake constants in brain, myocardium, skeletal muscle, and liver computed by the Patlak analysis using estimated and measured plasma IFs were in excellent agreement (slope ∼ 1; R 2 > 0.983). The IF estimated using only the last blood sample drawn at the end of the study and the use of liver TAC as the plasma IF provided less reliable results. The estimated plasma IFs obtained with the hybrid method agreed well with those derived from arterial blood sampling. Importantly, the proposed method obviates the need of arterial catheterization, making it possible to perform repeated dynamic [18F]FDG PET studies on the same animal. Liver TAC is unsuitable as an input function for absolute quantification of [18F]FDG PET data." @default.
• W2154617657 created "2016-06-24" @default.
• W2154617657 creator A5054228072 @default.
• W2154617657 creator A5070051140 @default.
• W2154617657 creator A5087906240 @default.
• W2154617657 date "2013-01-16" @default.
• W2154617657 modified "2023-09-30" @default.
• W2154617657 title "Improved Derivation of Input Function in Dynamic Mouse [18F]FDG PET Using Bladder Radioactivity Kinetics" @default.
• W2154617657 cites W1973278822 @default.
• W2154617657 cites W1982672672 @default.
• W2154617657 cites W1983817514 @default.
• W2154617657 cites W2001557269 @default.
• W2154617657 cites W2002477254 @default.
• W2154617657 cites W2003931977 @default.
• W2154617657 cites W2015795623 @default.
• W2154617657 cites W2037211078 @default.
• W2154617657 cites W2070109486 @default.
• W2154617657 cites W2070997349 @default.
• W2154617657 cites W2080110262 @default.
• W2154617657 cites W2090306035 @default.
• W2154617657 cites W2092078486 @default.
• W2154617657 cites W2107945436 @default.
• W2154617657 cites W2112547854 @default.
• W2154617657 cites W2113936404 @default.
• W2154617657 cites W2114428276 @default.
• W2154617657 cites W2129318972 @default.
• W2154617657 cites W2131706886 @default.
• W2154617657 cites W2156317861 @default.
• W2154617657 cites W2158346905 @default.
• W2154617657 cites W2161281052 @default.
• W2154617657 doi "https://doi.org/10.1007/s11307-013-0610-6" @default.
• W2154617657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3812956" @default.
• W2154617657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23322346" @default.
• W2154617657 hasPublicationYear "2013" @default.
• W2154617657 type Work @default.
• W2154617657 sameAs 2154617657 @default.
• W2154617657 citedByCount "14" @default.
• W2154617657 countsByYear W21546176572014 @default.
• W2154617657 countsByYear W21546176572015 @default.
• W2154617657 countsByYear W21546176572016 @default.
• W2154617657 countsByYear W21546176572017 @default.
• W2154617657 countsByYear W21546176572018 @default.
• W2154617657 countsByYear W21546176572020 @default.
• W2154617657 countsByYear W21546176572021 @default.
• W2154617657 countsByYear W21546176572022 @default.
• W2154617657 countsByYear W21546176572023 @default.
• W2154617657 crossrefType "journal-article" @default.
• W2154617657 hasAuthorship W2154617657A5054228072 @default.
• W2154617657 hasAuthorship W2154617657A5070051140 @default.
• W2154617657 hasAuthorship W2154617657A5087906240 @default.
• W2154617657 hasBestOaLocation W21546176572 @default.
• W2154617657 hasConcept C126322002 @default.
• W2154617657 hasConcept C126838900 @default.
• W2154617657 hasConcept C158846371 @default.
• W2154617657 hasConcept C185592680 @default.
• W2154617657 hasConcept C2775842073 @default.
• W2154617657 hasConcept C2988731192 @default.
• W2154617657 hasConcept C2989005 @default.
• W2154617657 hasConcept C37557685 @default.
• W2154617657 hasConcept C71924100 @default.
• W2154617657 hasConceptScore W2154617657C126322002 @default.
• W2154617657 hasConceptScore W2154617657C126838900 @default.
• W2154617657 hasConceptScore W2154617657C158846371 @default.
• W2154617657 hasConceptScore W2154617657C185592680 @default.
• W2154617657 hasConceptScore W2154617657C2775842073 @default.
• W2154617657 hasConceptScore W2154617657C2988731192 @default.
• W2154617657 hasConceptScore W2154617657C2989005 @default.
• W2154617657 hasConceptScore W2154617657C37557685 @default.
• W2154617657 hasConceptScore W2154617657C71924100 @default.
• W2154617657 hasIssue "4" @default.
• W2154617657 hasLocation W21546176571 @default.
• W2154617657 hasLocation W21546176572 @default.
• W2154617657 hasLocation W21546176573 @default.
• W2154617657 hasLocation W21546176574 @default.
• W2154617657 hasOpenAccess W2154617657 @default.
• W2154617657 hasPrimaryLocation W21546176571 @default.
• W2154617657 hasRelatedWork W1871634784 @default.
• W2154617657 hasRelatedWork W1924023774 @default.
• W2154617657 hasRelatedWork W1980902942 @default.
• W2154617657 hasRelatedWork W1990858389 @default.
• W2154617657 hasRelatedWork W1991707478 @default.
• W2154617657 hasRelatedWork W2040536103 @default.
• W2154617657 hasRelatedWork W2413756896 @default.
• W2154617657 hasRelatedWork W2419124614 @default.
• W2154617657 hasRelatedWork W2801547046 @default.
• W2154617657 hasRelatedWork W3146521945 @default.
• W2154617657 hasVolume "15" @default.
• W2154617657 isParatext "false" @default.
• W2154617657 isRetracted "false" @default.
• W2154617657 magId "2154617657" @default.
• W2154617657 workType "article" @default.