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- W2154647178 abstract "Introduction: Increased large artery stiffness is associated with adverse cardiovascular outcomes, related to an increase in cardiac work and reduction in coronary blood flow (CBF). We sort to assess a simple non-invasive method, adenosine stress cardiacMRI (ASCMR), in determining the relationship between large artery stiffness and myocardial perfusion. Methods:We studied 40 subjects with stable chest pain referred for ASCMR who were subsequently found to have no myocardial ischaemia and normal LV function. ASCMR was performed with a standard infusion protocol. Three short-axis images of LV were obtained at stress and rest. Cross-sectional area of the mid thoracic descending aorta was measured and aortic distensibility (AD, inverse of stiffness) calculated as (aortic area in systole− aortic area in diastole)/(pulse pressure× aortic area in diastole). Left ventricular perfusion was evaluated off-line using QMass software. The myocardial perfusion reserve index (MPRI) was calculated as (Myocardial Blood Flow At Stress/Myocardial Blood Flow At Rest) and was represented as an average of all myocardial segments. Results: Forty patients were studied (60± 11 years; 19 males). At baseline mean BP was 107mmHg (range 76–133). On univariate analysis AD correlated with MPRI (p= 0.015, r= 0.433). After accounting for other clinical variables including hypertension, smoking, diabetes, hypercholesterolaemia and gender in multivariate analysis, correlation between AD and MPRI remained (p= 0.031). Age also correlated with AD as demonstrated in earlier studies. Conclusion: ASCMR can demonstrate relationship between arterial stiffness and MPRI. This offers potential to evaluate impact of other disease processes known to increase aortic stiffness on ventriculo-vascular interaction and CBF." @default.
- W2154647178 created "2016-06-24" @default.
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- W2154647178 date "2010-01-01" @default.
- W2154647178 modified "2023-09-28" @default.
- W2154647178 title "Arterial Stiffness Predicts Myocardial Perfusion Reserve: An Adenosine Stress Cardiac Magnetic Resonance Study" @default.
- W2154647178 doi "https://doi.org/10.1016/j.hlc.2010.06.688" @default.
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