FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154679095> ?p ?o ?g. }

• W2154679095 endingPage "32" @default.
• W2154679095 startingPage "26" @default.
• W2154679095 abstract "Background Obesity is an important risk factor for knee osteoarthritis (OA), Weight loss can reduce the symptoms of knee OA. No prospective studies assessing the impact of weight loss on knee cartilage structure and composition have been performed. Objectives To assess the impact of weight loss on knee cartilage thickness and composition. Methods 111 obese adults were recruited from either laparoscopic adjustable gastric banding or exercise and diet weight loss programmes from two tertiary centres. MRI was performed at baseline and 12-month follow-up to assess cartilage thickness. 78 eligible subjects also underwent delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), an estimate of proteoglycan content. The associations between cartilage outcomes (cartilage thickness and dGEMRIC index) and weight loss were adjusted for age, gender, body mass index (BMI) and presence of clinical knee OA. Results Mean age was 51.7±11.8 years and mean BMI was 36.6±5.8 kg/m 2 ; 32% had clinical knee OA. Mean weight loss was 9.3±11.9%. Percentage weight loss was negatively associated with cartilage thickness loss in the medial femoral compartment in multiple regression analysis (β=0.006, r 2 =0.19, p=0.029). This association was not detected in the lateral compartment (r 2 =0.12, p=0.745). Percentage weight loss was associated with an increase in medial dGEMRIC in multiple regression analysis (β=3.9, r 2 =0.26; p=0.008) but not the lateral compartment (r 2 =0.14, p=0.34). For every 10% weight loss there was a gain in the medial dGEMRIC index of 39 ms (r 2 =0.28; p=0.014). The lowest weight loss cut-off associated with reduced medial femoral cartilage thickness loss and improved medial dGEMRIC index was 7%. Conclusions Weight loss is associated with improvements in the quality (increased proteoglycan content) and quantity (reduced cartilage thickness losses) of medial articular cartilage. This was not observed in the lateral compartment. This could ultimately lead to a reduced need for total joint replacements and is thus a finding with important public health implications." @default.
• W2154679095 created "2016-06-24" @default.
• W2154679095 creator A5005411007 @default.
• W2154679095 creator A5011311836 @default.
• W2154679095 creator A5011312213 @default.
• W2154679095 creator A5017944142 @default.
• W2154679095 creator A5023260286 @default.
• W2154679095 creator A5039644796 @default.
• W2154679095 creator A5041134602 @default.
• W2154679095 creator A5069633317 @default.
• W2154679095 date "2011-11-30" @default.
• W2154679095 modified "2023-09-30" @default.
• W2154679095 title "Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage" @default.
• W2154679095 cites W1536268847 @default.
• W2154679095 cites W1827112329 @default.
• W2154679095 cites W1849076209 @default.
• W2154679095 cites W1970166738 @default.
• W2154679095 cites W1972418279 @default.
• W2154679095 cites W1981673806 @default.
• W2154679095 cites W1983075462 @default.
• W2154679095 cites W1985581924 @default.
• W2154679095 cites W1991089386 @default.
• W2154679095 cites W1995398158 @default.
• W2154679095 cites W199810177 @default.
• W2154679095 cites W2000684753 @default.
• W2154679095 cites W2001911932 @default.
• W2154679095 cites W2007476414 @default.
• W2154679095 cites W2007524351 @default.
• W2154679095 cites W2012519628 @default.
• W2154679095 cites W2014106551 @default.
• W2154679095 cites W2017022352 @default.
• W2154679095 cites W2019401802 @default.
• W2154679095 cites W2024589117 @default.
• W2154679095 cites W2029650494 @default.
• W2154679095 cites W2033133946 @default.
• W2154679095 cites W2033584222 @default.
• W2154679095 cites W2034201007 @default.
• W2154679095 cites W2035213963 @default.
• W2154679095 cites W2043350870 @default.
• W2154679095 cites W2044150688 @default.
• W2154679095 cites W2044577493 @default.
• W2154679095 cites W2047803832 @default.
• W2154679095 cites W2048826456 @default.
• W2154679095 cites W2050849801 @default.
• W2154679095 cites W2057890127 @default.
• W2154679095 cites W2058147305 @default.
• W2154679095 cites W2060859480 @default.
• W2154679095 cites W2067422331 @default.
• W2154679095 cites W2067742362 @default.
• W2154679095 cites W2071874352 @default.
• W2154679095 cites W2075685415 @default.
• W2154679095 cites W2082834811 @default.
• W2154679095 cites W2083546827 @default.
• W2154679095 cites W2086103864 @default.
• W2154679095 cites W2088023471 @default.
• W2154679095 cites W2089955270 @default.
• W2154679095 cites W2104310336 @default.
• W2154679095 cites W2119436921 @default.
• W2154679095 cites W2121467598 @default.
• W2154679095 cites W2123377713 @default.
• W2154679095 cites W2128344525 @default.
• W2154679095 cites W2128650484 @default.
• W2154679095 cites W2137057333 @default.
• W2154679095 cites W2146463166 @default.
• W2154679095 cites W2149728635 @default.
• W2154679095 cites W2155167516 @default.
• W2154679095 cites W2167872444 @default.
• W2154679095 cites W2168342322 @default.
• W2154679095 cites W2335405361 @default.
• W2154679095 cites W2971005880 @default.
• W2154679095 doi "https://doi.org/10.1136/ard.2010.144725" @default.
• W2154679095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22135412" @default.
• W2154679095 hasPublicationYear "2011" @default.
• W2154679095 type Work @default.
• W2154679095 sameAs 2154679095 @default.
• W2154679095 citedByCount "131" @default.
• W2154679095 countsByYear W21546790952012 @default.
• W2154679095 countsByYear W21546790952013 @default.
• W2154679095 countsByYear W21546790952014 @default.
• W2154679095 countsByYear W21546790952015 @default.
• W2154679095 countsByYear W21546790952016 @default.
• W2154679095 countsByYear W21546790952017 @default.
• W2154679095 countsByYear W21546790952018 @default.
• W2154679095 countsByYear W21546790952019 @default.
• W2154679095 countsByYear W21546790952020 @default.
• W2154679095 countsByYear W21546790952021 @default.
• W2154679095 countsByYear W21546790952022 @default.
• W2154679095 countsByYear W21546790952023 @default.
• W2154679095 crossrefType "journal-article" @default.
• W2154679095 hasAuthorship W2154679095A5005411007 @default.
• W2154679095 hasAuthorship W2154679095A5011311836 @default.
• W2154679095 hasAuthorship W2154679095A5011312213 @default.
• W2154679095 hasAuthorship W2154679095A5017944142 @default.
• W2154679095 hasAuthorship W2154679095A5023260286 @default.
• W2154679095 hasAuthorship W2154679095A5039644796 @default.
• W2154679095 hasAuthorship W2154679095A5041134602 @default.
• W2154679095 hasAuthorship W2154679095A5069633317 @default.
• W2154679095 hasBestOaLocation W21546790951 @default.

• next