FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154687556> ?p ?o ?g. }

• W2154687556 abstract "Abstract Background Tight correlation between host circulating CD8+ T cell-mediated immune response and control of viral replication is classical characteristic of long-term HCV infection. CD8+ T cell maturation/activation markers are expected to be associated with viral replication and disease progression in chronic HCV infection. The aim of the present study was to explore novel markers on CD8+ T cells with ability to evaluate HCV viral replication and disease progression. Methods PBMCs were isolated from 37 chronic HCV-infected patients and 17 healthy controls. Distributed pattern of CD8+ T cells subsets and expression of PD-1, CD38, HLA-DR and CD127 were analyzed by flow cytometry. The correlation between expression of surface markers and HCV viral load or ALT was studied. Results Declined naïve and increased TEMRA CD8+ T subsets were found in HCV-infected individuals compared with healthy controls. Percentage and MFI of PD-1, CD38 and HLA-DR on all CD8+ T cell subsets were higher in HCV-infected patients than healthy controls. In contrast, CD127 expression on CD8+ TCM showed an opposite trend as PD-1, CD38 and HLA-DR did. In chronic HCV infection, MFI of PD-1 on CD8+ TEM (p < 0.0001) and TEMRA (p = 0.0015) was positively correlated with HCV viral load while HLA-DR expression on non-naive CD8+ T cell subsets (p < 0.05) was negatively correlated with HCV viral load. Conclusion PD-1 level on peripheral CD8+ TEM/TEMRA was highly correlated with HCV viral load in chronic HCV-infected patients, which made PD-1 a novel indicator to evaluate HCV replication and disease progression in chronic hepatitis C patients." @default.
• W2154687556 created "2016-06-24" @default.
• W2154687556 creator A5003759585 @default.
• W2154687556 creator A5046685876 @default.
• W2154687556 creator A5057117256 @default.
• W2154687556 creator A5068428294 @default.
• W2154687556 creator A5080159973 @default.
• W2154687556 creator A5083644070 @default.
• W2154687556 creator A5090272584 @default.
• W2154687556 date "2010-11-12" @default.
• W2154687556 modified "2023-09-26" @default.
• W2154687556 title "PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients" @default.
• W2154687556 cites W1511803520 @default.
• W2154687556 cites W1627211503 @default.
• W2154687556 cites W1653338534 @default.
• W2154687556 cites W1665733615 @default.
• W2154687556 cites W1964179737 @default.
• W2154687556 cites W1970347634 @default.
• W2154687556 cites W1974842026 @default.
• W2154687556 cites W1978436252 @default.
• W2154687556 cites W1981480494 @default.
• W2154687556 cites W1985511137 @default.
• W2154687556 cites W1986376227 @default.
• W2154687556 cites W1989273697 @default.
• W2154687556 cites W1993617345 @default.
• W2154687556 cites W2010019194 @default.
• W2154687556 cites W2013013791 @default.
• W2154687556 cites W2029128444 @default.
• W2154687556 cites W2030259456 @default.
• W2154687556 cites W2034530063 @default.
• W2154687556 cites W2050466666 @default.
• W2154687556 cites W2051211650 @default.
• W2154687556 cites W2056267734 @default.
• W2154687556 cites W2057499380 @default.
• W2154687556 cites W2071911570 @default.
• W2154687556 cites W2075819066 @default.
• W2154687556 cites W2077884399 @default.
• W2154687556 cites W2082797461 @default.
• W2154687556 cites W2085452716 @default.
• W2154687556 cites W2087374360 @default.
• W2154687556 cites W2104013211 @default.
• W2154687556 cites W2104233210 @default.
• W2154687556 cites W2106544064 @default.
• W2154687556 cites W2113331651 @default.
• W2154687556 cites W2113847305 @default.
• W2154687556 cites W2121931877 @default.
• W2154687556 cites W2123895023 @default.
• W2154687556 cites W2129084642 @default.
• W2154687556 cites W2130259551 @default.
• W2154687556 cites W2132264213 @default.
• W2154687556 cites W2133067107 @default.
• W2154687556 cites W2137929296 @default.
• W2154687556 cites W2139103918 @default.
• W2154687556 cites W2142621481 @default.
• W2154687556 cites W2145076873 @default.
• W2154687556 cites W2147453145 @default.
• W2154687556 cites W2149748445 @default.
• W2154687556 cites W2151712474 @default.
• W2154687556 cites W2152193720 @default.
• W2154687556 cites W2169735985 @default.
• W2154687556 cites W2171633892 @default.
• W2154687556 cites W2183146101 @default.
• W2154687556 cites W4229663730 @default.
• W2154687556 doi "https://doi.org/10.1186/1743-422x-7-310" @default.
• W2154687556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2989324" @default.
• W2154687556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21070674" @default.
• W2154687556 hasPublicationYear "2010" @default.
• W2154687556 type Work @default.
• W2154687556 sameAs 2154687556 @default.
• W2154687556 citedByCount "35" @default.
• W2154687556 countsByYear W21546875562012 @default.
• W2154687556 countsByYear W21546875562013 @default.
• W2154687556 countsByYear W21546875562014 @default.
• W2154687556 countsByYear W21546875562015 @default.
• W2154687556 countsByYear W21546875562016 @default.
• W2154687556 countsByYear W21546875562018 @default.
• W2154687556 countsByYear W21546875562019 @default.
• W2154687556 countsByYear W21546875562020 @default.
• W2154687556 countsByYear W21546875562021 @default.
• W2154687556 countsByYear W21546875562022 @default.
• W2154687556 crossrefType "journal-article" @default.
• W2154687556 hasAuthorship W2154687556A5003759585 @default.
• W2154687556 hasAuthorship W2154687556A5046685876 @default.
• W2154687556 hasAuthorship W2154687556A5057117256 @default.
• W2154687556 hasAuthorship W2154687556A5068428294 @default.
• W2154687556 hasAuthorship W2154687556A5080159973 @default.
• W2154687556 hasAuthorship W2154687556A5083644070 @default.
• W2154687556 hasAuthorship W2154687556A5090272584 @default.
• W2154687556 hasBestOaLocation W21546875561 @default.
• W2154687556 hasConcept C10205521 @default.
• W2154687556 hasConcept C123982805 @default.
• W2154687556 hasConcept C140704245 @default.
• W2154687556 hasConcept C142462285 @default.
• W2154687556 hasConcept C159047783 @default.
• W2154687556 hasConcept C159912055 @default.
• W2154687556 hasConcept C167672396 @default.
• W2154687556 hasConcept C203014093 @default.
• W2154687556 hasConcept C2522874641 @default.
• W2154687556 hasConcept C2776090121 @default.
• W2154687556 hasConcept C2776408679 @default.

• next