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• W2154690748 endingPage "S430" @default.
• W2154690748 startingPage "S420" @default.
• W2154690748 abstract "Work from this laboratory on the immunogens of Mycobacterium species has focused on those based on carbohydrates (with a view to the development of specific tools for the serodiagnosis of mycobacterioses) and on the cell-wall proteins, as a source of protective immunity and as a means of observing specific delayed-type hypersensitivity. Most mycobacteria are endowed with specific, highly antigenic glycolipids that are powerful for the serodiagnosis of individual mycobacterial infections: e.g., the phenolic glycolipids of Mycobacterium leprae and Mycobacterium bovis, the glycopeptidolipids of the Mycobacterium avium complex, and the acylated trehalose-containing lipooligosaccharides of species such as Mycobacterium kansasii, Mycobacterium szulgai, and Mycobacterium malmoense. A search for analogous structures in Mycobacterium tuberculosis has revealed an antigenic diglycosyl diacylglycerol and the immunogenic phosphomannoinositides. Others have reported on the presence of a novel phenolic glycolipid in the Canetti strain of M tuberculosis. The dominant carbohydrate-containing antigen of M. tuberculosis (responsible for the high-titer anti-arabinofuranosyl activity in tuberculous sera) is lipoarabinomannan, which has been purified in the native state from M tuberculosis and shown to contain both phosphatidylinositol and phospho inositol side-branches. The cell wall of M. tuberculosis — more precisely, the peptidoglycan skeleton — is a source of a few distinct, highly immunogenic protein antigens. The recognition, isolation, and characterization of these antigens will also be described." @default.
• W2154690748 created "2016-06-24" @default.
• W2154690748 creator A5012975065 @default.
• W2154690748 date "1989-03-01" @default.
• W2154690748 modified "2023-10-02" @default.
• W2154690748 title "Structure of Mycobacteria: Recent Developments in Defining Cell Wall Carbohydrates and Proteins" @default.
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• W2154690748 doi "https://doi.org/10.1093/clinids/11.supplement_2.s420" @default.
• W2154690748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2469120" @default.
• W2154690748 hasPublicationYear "1989" @default.
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