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- W2154695325 abstract "Study Objective. To quantify the risk of cognitive impairment with use of lipid-lowering drugs. Design and Data Sources. Literature search through MEDLINE and EMBASE databases; data from seven observational studies were analyzed. Measurements and Main Results. We quantified the risk of cognitive impairment first with the use of any lipid-lowering drug, and then specifically with the statins, using the random effects model. We tested for heterogeneity using the Q statistic as well as quantitatively using the Ristatistic. All seven studies provided data for statin users, and five provided data only on use of lipid-lowering drugs. Compared with patients not receiving lipid-lowering drugs, the relative risk of cognitive impairment with any lipid-lowering drug was 0.62 but was not statistically significant (95% confidence interval [CI] 0.28–1.38), and the relative risk with statins was 0.43 and was statistically significant (95% CI 0.31–0.62). Conclusion. Lipid-lowering drugs—in particular, the statins—seem to lower the odds of developing cognitive impairment. Randomized, controlled trials are needed to address the efficacy of these agents specifically in different types of dementia." @default.
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- W2154695325 date "2003-06-01" @default.
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- W2154695325 title "The Role of Lipid-Lowering Drugs in Cognitive Function: A Meta-Analysis of Observational Studies" @default.
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- W2154695325 doi "https://doi.org/10.1592/phco.23.6.726.32184" @default.
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