FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154696002> ?p ?o ?g. }

• W2154696002 endingPage "162" @default.
• W2154696002 startingPage "153" @default.
• W2154696002 abstract "Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypothalamic inflammatory signaling was evident in both rats and mice within 1 to 3 days of HFD onset, prior to substantial weight gain. Furthermore, both reactive gliosis and markers suggestive of neuron injury were evident in the hypothalamic arcuate nucleus of rats and mice within the first week of HFD feeding. Although these responses temporarily subsided, suggesting that neuroprotective mechanisms may initially limit the damage, with continued HFD feeding, inflammation and gliosis returned permanently to the mediobasal hypothalamus. Consistent with these data in rodents, we found evidence of increased gliosis in the mediobasal hypothalamus of obese humans, as assessed by MRI. These findings collectively suggest that, in both humans and rodent models, obesity is associated with neuronal injury in a brain area crucial for body weight control." @default.
• W2154696002 created "2016-06-24" @default.
• W2154696002 creator A5000358288 @default.
• W2154696002 creator A5003708330 @default.
• W2154696002 creator A5003734252 @default.
• W2154696002 creator A5011770404 @default.
• W2154696002 creator A5012879275 @default.
• W2154696002 creator A5013784745 @default.
• W2154696002 creator A5014454431 @default.
• W2154696002 creator A5018963859 @default.
• W2154696002 creator A5021482790 @default.
• W2154696002 creator A5023048372 @default.
• W2154696002 creator A5027165267 @default.
• W2154696002 creator A5035450241 @default.
• W2154696002 creator A5051033975 @default.
• W2154696002 creator A5053926256 @default.
• W2154696002 creator A5063866141 @default.
• W2154696002 creator A5067946092 @default.
• W2154696002 creator A5081110082 @default.
• W2154696002 creator A5088091814 @default.
• W2154696002 creator A5089487347 @default.
• W2154696002 date "2012-01-03" @default.
• W2154696002 modified "2023-10-17" @default.
• W2154696002 title "Obesity is associated with hypothalamic injury in rodents and humans" @default.
• W2154696002 cites W1514528045 @default.
• W2154696002 cites W1964562779 @default.
• W2154696002 cites W1973863972 @default.
• W2154696002 cites W1980789245 @default.
• W2154696002 cites W1984751686 @default.
• W2154696002 cites W1998525855 @default.
• W2154696002 cites W2001776102 @default.
• W2154696002 cites W2003674452 @default.
• W2154696002 cites W2012730798 @default.
• W2154696002 cites W2016890949 @default.
• W2154696002 cites W2017614405 @default.
• W2154696002 cites W2017712441 @default.
• W2154696002 cites W2018131701 @default.
• W2154696002 cites W2023952845 @default.
• W2154696002 cites W2039474189 @default.
• W2154696002 cites W2039749588 @default.
• W2154696002 cites W2053176712 @default.
• W2154696002 cites W2063666823 @default.
• W2154696002 cites W2064842282 @default.
• W2154696002 cites W2067875627 @default.
• W2154696002 cites W2075792687 @default.
• W2154696002 cites W2077033935 @default.
• W2154696002 cites W2077335475 @default.
• W2154696002 cites W2079395662 @default.
• W2154696002 cites W2080194836 @default.
• W2154696002 cites W2085424855 @default.
• W2154696002 cites W2092310066 @default.
• W2154696002 cites W2105987351 @default.
• W2154696002 cites W2112880160 @default.
• W2154696002 cites W2123214581 @default.
• W2154696002 cites W2127166001 @default.
• W2154696002 cites W2128313606 @default.
• W2154696002 cites W2147372806 @default.
• W2154696002 cites W2149079606 @default.
• W2154696002 cites W2152377123 @default.
• W2154696002 cites W2154993634 @default.
• W2154696002 cites W2157137975 @default.
• W2154696002 cites W2160935383 @default.
• W2154696002 cites W2165604976 @default.
• W2154696002 cites W2166622194 @default.
• W2154696002 cites W2169612876 @default.
• W2154696002 cites W2171549018 @default.
• W2154696002 cites W4249727000 @default.
• W2154696002 doi "https://doi.org/10.1172/jci59660" @default.
• W2154696002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266812" @default.
• W2154696002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22201683" @default.
• W2154696002 hasPublicationYear "2012" @default.
• W2154696002 type Work @default.
• W2154696002 sameAs 2154696002 @default.
• W2154696002 citedByCount "1392" @default.
• W2154696002 countsByYear W21546960022012 @default.
• W2154696002 countsByYear W21546960022013 @default.
• W2154696002 countsByYear W21546960022014 @default.
• W2154696002 countsByYear W21546960022015 @default.
• W2154696002 countsByYear W21546960022016 @default.
• W2154696002 countsByYear W21546960022017 @default.
• W2154696002 countsByYear W21546960022018 @default.
• W2154696002 countsByYear W21546960022019 @default.
• W2154696002 countsByYear W21546960022020 @default.
• W2154696002 countsByYear W21546960022021 @default.
• W2154696002 countsByYear W21546960022022 @default.
• W2154696002 countsByYear W21546960022023 @default.
• W2154696002 crossrefType "journal-article" @default.
• W2154696002 hasAuthorship W2154696002A5000358288 @default.
• W2154696002 hasAuthorship W2154696002A5003708330 @default.
• W2154696002 hasAuthorship W2154696002A5003734252 @default.
• W2154696002 hasAuthorship W2154696002A5011770404 @default.
• W2154696002 hasAuthorship W2154696002A5012879275 @default.
• W2154696002 hasAuthorship W2154696002A5013784745 @default.
• W2154696002 hasAuthorship W2154696002A5014454431 @default.
• W2154696002 hasAuthorship W2154696002A5018963859 @default.
• W2154696002 hasAuthorship W2154696002A5021482790 @default.
• W2154696002 hasAuthorship W2154696002A5023048372 @default.
• W2154696002 hasAuthorship W2154696002A5027165267 @default.

• next