FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154704311> ?p ?o ?g. }

• W2154704311 endingPage "474" @default.
• W2154704311 startingPage "467" @default.
• W2154704311 abstract "Hexavalent chromium [Cr(VI)] is a genotoxic carcinogen for which inhalation is a major potential route of exposure in occupational settings. In the present study, the ability of sodium dichromate to cause DNA strand breaks in three populations of cells, human whole blood cells, isolated human peripheral blood lymphocytes and cultured A549 lung epithelial cells, was investigated. Treatment with non-cytotoxic concentrations of sodium dichromate (for 1 h) resulted in a concentration-dependent increase in the number of DNA strand breaks as measured by the Comet assay. The lowest concentrations of sodium dichromate that resulted in a statistically significant (P < 0.01) increase in the number of DNA strand breaks were 500, 50 and 10 microM, respectively, in these cells. The use of formamidopyrimidine glycosylase increased the sensitivity of detection of strand breaks in A549 cells 10-fold, suggesting a role for DNA base oxidation in the mechanism of dichromate-induced DNA strand breaks. In support of this hypothesis, immunocytochemistry indicated an elevation of 8-oxodeoxyguanosine in A549 cells treated with 10 and 500 microM sodium dichromate for 1 h. We also demonstrated 2.11- and 2.5-fold ranges in the level of control and dichromate (500 microM)-induced DNA strand breaks, respectively, in cells of whole blood within a group of healthy volunteers (n = 26). A statistically significant (P < 0.001) positive Pearson's correlation (r = 0.606) was found between control and treated levels of DNA strand breaks, suggesting that factors responsible for relatively low levels of DNA strand breaks in untreated PBL may also offer protection against the formation of dichromate-induced DNA strand breaks." @default.
• W2154704311 created "2016-06-24" @default.
• W2154704311 creator A5004304441 @default.
• W2154704311 creator A5005827844 @default.
• W2154704311 creator A5027095776 @default.
• W2154704311 creator A5051293383 @default.
• W2154704311 creator A5086032060 @default.
• W2154704311 date "2001-11-01" @default.
• W2154704311 modified "2023-10-16" @default.
• W2154704311 title "Induction of DNA-strand breaks in human peripheral blood lymphocytes and A549 lung cells by sodium dichromate: association with 8-oxo-2-deoxyguanosine formation and inter-individual variability" @default.
• W2154704311 cites W1559702002 @default.
• W2154704311 cites W1568755077 @default.
• W2154704311 cites W1648389938 @default.
• W2154704311 cites W1964374342 @default.
• W2154704311 cites W1968499584 @default.
• W2154704311 cites W1968891552 @default.
• W2154704311 cites W1984026682 @default.
• W2154704311 cites W1986437330 @default.
• W2154704311 cites W1993163605 @default.
• W2154704311 cites W2001004431 @default.
• W2154704311 cites W2001962665 @default.
• W2154704311 cites W2003976967 @default.
• W2154704311 cites W2004728426 @default.
• W2154704311 cites W2007009509 @default.
• W2154704311 cites W2014886324 @default.
• W2154704311 cites W2018218159 @default.
• W2154704311 cites W2023814268 @default.
• W2154704311 cites W2028283174 @default.
• W2154704311 cites W2029710018 @default.
• W2154704311 cites W2034759967 @default.
• W2154704311 cites W2041380501 @default.
• W2154704311 cites W2044743189 @default.
• W2154704311 cites W2047562420 @default.
• W2154704311 cites W2050028436 @default.
• W2154704311 cites W2055967430 @default.
• W2154704311 cites W2056051410 @default.
• W2154704311 cites W2059663269 @default.
• W2154704311 cites W2061443181 @default.
• W2154704311 cites W2061758955 @default.
• W2154704311 cites W2063205187 @default.
• W2154704311 cites W2078386567 @default.
• W2154704311 cites W2084150620 @default.
• W2154704311 cites W2085172497 @default.
• W2154704311 cites W2086764007 @default.
• W2154704311 cites W2092629964 @default.
• W2154704311 cites W2093798689 @default.
• W2154704311 cites W2094185660 @default.
• W2154704311 cites W2105426204 @default.
• W2154704311 cites W2114882751 @default.
• W2154704311 cites W2124352629 @default.
• W2154704311 cites W2125163174 @default.
• W2154704311 cites W2147062173 @default.
• W2154704311 cites W2150115597 @default.
• W2154704311 cites W2162403933 @default.
• W2154704311 cites W2168615268 @default.
• W2154704311 cites W2236824038 @default.
• W2154704311 cites W2401822950 @default.
• W2154704311 cites W2416711677 @default.
• W2154704311 doi "https://doi.org/10.1093/mutage/16.6.467" @default.
• W2154704311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11682636" @default.
• W2154704311 hasPublicationYear "2001" @default.
• W2154704311 type Work @default.
• W2154704311 sameAs 2154704311 @default.
• W2154704311 citedByCount "51" @default.
• W2154704311 countsByYear W21547043112012 @default.
• W2154704311 countsByYear W21547043112013 @default.
• W2154704311 countsByYear W21547043112014 @default.
• W2154704311 countsByYear W21547043112015 @default.
• W2154704311 countsByYear W21547043112016 @default.
• W2154704311 countsByYear W21547043112017 @default.
• W2154704311 countsByYear W21547043112018 @default.
• W2154704311 countsByYear W21547043112022 @default.
• W2154704311 countsByYear W21547043112023 @default.
• W2154704311 crossrefType "journal-article" @default.
• W2154704311 hasAuthorship W2154704311A5004304441 @default.
• W2154704311 hasAuthorship W2154704311A5005827844 @default.
• W2154704311 hasAuthorship W2154704311A5027095776 @default.
• W2154704311 hasAuthorship W2154704311A5051293383 @default.
• W2154704311 hasAuthorship W2154704311A5086032060 @default.
• W2154704311 hasBestOaLocation W21547043111 @default.
• W2154704311 hasConcept C143425029 @default.
• W2154704311 hasConcept C1491633281 @default.
• W2154704311 hasConcept C153911025 @default.
• W2154704311 hasConcept C179104552 @default.
• W2154704311 hasConcept C185592680 @default.
• W2154704311 hasConcept C2777567952 @default.
• W2154704311 hasConcept C2780358455 @default.
• W2154704311 hasConcept C552990157 @default.
• W2154704311 hasConcept C55493867 @default.
• W2154704311 hasConcept C81729549 @default.
• W2154704311 hasConcept C86803240 @default.
• W2154704311 hasConceptScore W2154704311C143425029 @default.
• W2154704311 hasConceptScore W2154704311C1491633281 @default.
• W2154704311 hasConceptScore W2154704311C153911025 @default.
• W2154704311 hasConceptScore W2154704311C179104552 @default.
• W2154704311 hasConceptScore W2154704311C185592680 @default.
• W2154704311 hasConceptScore W2154704311C2777567952 @default.
• W2154704311 hasConceptScore W2154704311C2780358455 @default.

• next