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• W2154731415 abstract "Mossy cell loss and mossy fiber sprouting are two characteristic consequences of repeated seizures and head trauma. However, their precise contributions to the hyperexcitable state are not well understood. Because it is difficult, and frequently impossible, to independently examine using experimental techniques whether it is the loss of mossy cells or the sprouting of mossy fibers that leads to dentate hyperexcitability, we built a biophysically realistic and anatomically representative computational model of the dentate gyrus to examine this question. The 527-cell model, containing granule, mossy, basket, and hilar cells with axonal projections to the perforant-path termination zone, showed that even weak mossy fiber sprouting (10–15% of the strong sprouting observed in the pilocarpine model of epilepsy) resulted in the spread of seizure-like activity to the adjacent model hippocampal laminae after focal stimulation of the perforant path. The simulations also indicated that the spatially restricted, lamellar distribution of the sprouted mossy fiber contacts reported in in vivo studies was an important factor in sustaining seizure-like activity in the network. In contrast to the robust hyperexcitability-inducing effects of mossy fiber sprouting, removal of mossy cells resulted in decreased granule cell responses to perforant-path activation in agreement with recent experimental data. These results indicate the crucial role of mossy fiber sprouting even in situations where there is only relatively weak mossy fiber sprouting as is the case after moderate concussive experimental head injury." @default.
• W2154731415 created "2016-06-24" @default.
• W2154731415 creator A5004136112 @default.
• W2154731415 creator A5053472937 @default.
• W2154731415 creator A5054420671 @default.
• W2154731415 date "2005-01-01" @default.
• W2154731415 modified "2023-10-16" @default.
• W2154731415 title "Role of Mossy Fiber Sprouting and Mossy Cell Loss in Hyperexcitability: A Network Model of the Dentate Gyrus Incorporating Cell Types and Axonal Topography" @default.
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• W2154731415 doi "https://doi.org/10.1152/jn.00777.2004" @default.
• W2154731415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15342722" @default.
• W2154731415 hasPublicationYear "2005" @default.
• W2154731415 type Work @default.

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