FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154731991> ?p ?o ?g. }

• W2154731991 endingPage "2080" @default.
• W2154731991 startingPage "2075" @default.
• W2154731991 abstract "Abstract Homocysteine is a sulfur-containing amino acid, which is synthesized from the precursor methionine through a multi-step process, and then reconverted to methionine or catabolyzed into cysteine. The presence of vitamin B9 (folic acid), vitamin B6 (pyridoxine) and vitamin B12 (cobalamin) is essential in homocysteine metabolism, wherein deficiency of one or more of these nutrients is associated with various degree of hyperhomocysteinemia. There is little doubt that hyperhomocysteinemia is associated with several human disorders, such as cardiovascular disease, neurodegenerative disorders, pregnancy complications and fractures, so that its measurement might be useful for risk assessment. Nevertheless, several randomized homocysteine-lowering therapy trials have failed to show that supplementation with vitamins B substantially modifies (and – more importantly – improves) the end points and the related outcomes. According to the current state of scientific knowledge, it seems thus reasonable to conclude that lowering homocysteine alone is probably insufficient to mitigate the risk of thromboembolic, cardiovascular and neurodegenerative disorders inasmuch as this bizarre amino acid acts in strict synergy with other probably more powerful risk factors. Several lines of evidence suggest, however, that its measurement may be helpful for identifying subjects at greater risk of disease, who may thus benefit from a more aggressive treatment of other modifiable risk factors, as recently shown by result of the 5-year Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial." @default.
• W2154731991 created "2016-06-24" @default.
• W2154731991 creator A5018059398 @default.
• W2154731991 creator A5073522064 @default.
• W2154731991 date "2012-11-28" @default.
• W2154731991 modified "2023-10-16" @default.
• W2154731991 title "Hyperhomocysteinemia in health and disease: where we are now, and where do we go from here?" @default.
• W2154731991 cites W1564357961 @default.
• W2154731991 cites W1703458018 @default.
• W2154731991 cites W1968367779 @default.
• W2154731991 cites W1971858702 @default.
• W2154731991 cites W1972288532 @default.
• W2154731991 cites W1975628470 @default.
• W2154731991 cites W1983168103 @default.
• W2154731991 cites W1987282243 @default.
• W2154731991 cites W1995136264 @default.
• W2154731991 cites W1998745138 @default.
• W2154731991 cites W2003588313 @default.
• W2154731991 cites W2016092443 @default.
• W2154731991 cites W2016093991 @default.
• W2154731991 cites W2019103495 @default.
• W2154731991 cites W2038744774 @default.
• W2154731991 cites W2051627448 @default.
• W2154731991 cites W2056593893 @default.
• W2154731991 cites W2075491309 @default.
• W2154731991 cites W2079456814 @default.
• W2154731991 cites W2080265235 @default.
• W2154731991 cites W2086461219 @default.
• W2154731991 cites W2124275823 @default.
• W2154731991 cites W2127266406 @default.
• W2154731991 cites W2144717748 @default.
• W2154731991 cites W2148698885 @default.
• W2154731991 cites W2198678228 @default.
• W2154731991 cites W2230430502 @default.
• W2154731991 cites W4211108970 @default.
• W2154731991 cites W4239210242 @default.
• W2154731991 doi "https://doi.org/10.1515/cclm-2012-0372" @default.
• W2154731991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23093205" @default.
• W2154731991 hasPublicationYear "2012" @default.
• W2154731991 type Work @default.
• W2154731991 sameAs 2154731991 @default.
• W2154731991 citedByCount "31" @default.
• W2154731991 countsByYear W21547319912013 @default.
• W2154731991 countsByYear W21547319912014 @default.
• W2154731991 countsByYear W21547319912015 @default.
• W2154731991 countsByYear W21547319912016 @default.
• W2154731991 countsByYear W21547319912017 @default.
• W2154731991 countsByYear W21547319912019 @default.
• W2154731991 countsByYear W21547319912020 @default.
• W2154731991 countsByYear W21547319912021 @default.
• W2154731991 countsByYear W21547319912022 @default.
• W2154731991 countsByYear W21547319912023 @default.
• W2154731991 crossrefType "journal-article" @default.
• W2154731991 hasAuthorship W2154731991A5018059398 @default.
• W2154731991 hasAuthorship W2154731991A5073522064 @default.
• W2154731991 hasBestOaLocation W21547319911 @default.
• W2154731991 hasConcept C126322002 @default.
• W2154731991 hasConcept C168563851 @default.
• W2154731991 hasConcept C177713679 @default.
• W2154731991 hasConcept C2776514930 @default.
• W2154731991 hasConcept C2776523773 @default.
• W2154731991 hasConcept C2777090595 @default.
• W2154731991 hasConcept C2779134260 @default.
• W2154731991 hasConcept C2779375456 @default.
• W2154731991 hasConcept C2779750884 @default.
• W2154731991 hasConcept C2780676250 @default.
• W2154731991 hasConcept C2780912031 @default.
• W2154731991 hasConcept C3020471959 @default.
• W2154731991 hasConcept C515207424 @default.
• W2154731991 hasConcept C55493867 @default.
• W2154731991 hasConcept C71924100 @default.
• W2154731991 hasConcept C86803240 @default.
• W2154731991 hasConceptScore W2154731991C126322002 @default.
• W2154731991 hasConceptScore W2154731991C168563851 @default.
• W2154731991 hasConceptScore W2154731991C177713679 @default.
• W2154731991 hasConceptScore W2154731991C2776514930 @default.
• W2154731991 hasConceptScore W2154731991C2776523773 @default.
• W2154731991 hasConceptScore W2154731991C2777090595 @default.
• W2154731991 hasConceptScore W2154731991C2779134260 @default.
• W2154731991 hasConceptScore W2154731991C2779375456 @default.
• W2154731991 hasConceptScore W2154731991C2779750884 @default.
• W2154731991 hasConceptScore W2154731991C2780676250 @default.
• W2154731991 hasConceptScore W2154731991C2780912031 @default.
• W2154731991 hasConceptScore W2154731991C3020471959 @default.
• W2154731991 hasConceptScore W2154731991C515207424 @default.
• W2154731991 hasConceptScore W2154731991C55493867 @default.
• W2154731991 hasConceptScore W2154731991C71924100 @default.
• W2154731991 hasConceptScore W2154731991C86803240 @default.
• W2154731991 hasIssue "12" @default.
• W2154731991 hasLocation W21547319911 @default.
• W2154731991 hasLocation W21547319912 @default.
• W2154731991 hasOpenAccess W2154731991 @default.
• W2154731991 hasPrimaryLocation W21547319911 @default.
• W2154731991 hasRelatedWork W1501004865 @default.
• W2154731991 hasRelatedWork W195945725 @default.
• W2154731991 hasRelatedWork W2002284604 @default.
• W2154731991 hasRelatedWork W2005259212 @default.
• W2154731991 hasRelatedWork W2008524997 @default.

• next